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Conversion of glioma cells to glioma stem-like cells by angiocrine factors

Biochemical and Biophysical Research Communications, 2018
Glioma stem-like cells (GSCs) contribute to tumor initiation, progression, and therapeutic resistance, but their cellular origin remains largely unknown. Here, using a stem/progenitor cell-fate tracking reporter system in which eGFP is expressed by promoter of OCT4 that is activated in stem/progenitor cells, we demonstrate that eGFP-negative glioma ...
Jun-Kyum Kim   +9 more
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Stem cells in gliomas

2012
Abstract The discovery of new neurons in adult mammalian brain challenged the concept of the adult vertebrate central nervous system (CNS) as a hard-wired immutable system. Following the description of neural stem cells (NSCs) in human brain during the last decade, increasing interest for their use as therapeutic agents has emerged.
Hugo, Guerrero-Cazares   +3 more
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Adenosine Signaling in Glioma Cells

2012
Purines and pyrimidines are fundamental signaling molecules in controlling the survival and proliferation of astrocytes, as well as in mediating cell-to-cell communication between glial cells and neurons in the healthy brain. The malignant transformation of astrocytes towards progressively more aggressive brain tumours (from astrocytoma to anaplastic ...
S. Ceruti, M. Abbracchio
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Cell carriers to attack glioma

Cytotherapy, 2014
In this issue of Cytotherapy, Lopez-Ornelas et al. present an elegant study using genetically modified neural stem cells (NSCs)as therapy forglioblastoma(GBM)(1).They demonstrate thatNSCs, geneticallymodified to express a soluble form of growth arrest specific 1 (Gas1) under the transcriptional control of an inducible promoter, migrate to glioma in ...
Simone, Krebs, Stephen, Gottschalk
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STAT Signaling in Glioma Cells

2012
STAT (signal transducers and activators of transcription) are latent cytoplasmic transcription factors that function as downstream effectors of cytokine and growth factor receptor signaling. The canonical JAK/STAT signaling pathway involves the activation of Janus kinases (JAK) or growth factors receptor kinases, phosphorylation of STAT proteins, their
Karolina, Swiatek-Machado   +1 more
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Cannabinoid Signaling in Glioma Cells

2012
Cannabinoids are a group of structurally heterogeneous but pharmacologically related compounds, including plant-derived cannabinoids, synthetic substances and endogenous cannabinoids, such as anandamide and 2-arachidonoylglycerol. Cannabinoids elicit a wide range of central and peripheral effects mostly mediated through cannabinoid receptors. There are
Aleksandra, Ellert-Miklaszewska   +2 more
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Characteristics of glioma stem cells

Brain Tumor Pathology, 2013
The cancer stem cell theory postulates that tumors are sustained by a select cell population with specific features, such as self-renewal ability and the capacity to give rise to a heterogeneous mass of tumor cells. The existence of such cells has been demonstrated for glioblastoma, with these cells being referred to as glioma stem cells (GSCs ...
Oltea, Sampetrean, Hideyuki, Saya
openaire   +2 more sources

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