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Glioma cells on the run: “Guerilla” cells as a fast migratory glioma cell population
201667. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS)
Adamski, V +3 more
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Neurochemical Research, 2008
Gliomas are the most common tumours of the central nervous system (CNS) and a frequent cause of mental impairment and death. Treatment of malignant gliomas is often palliative because of their infiltrating nature and high recurrence. Genetic events that lead to brain tumours are mostly unknown.
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Gliomas are the most common tumours of the central nervous system (CNS) and a frequent cause of mental impairment and death. Treatment of malignant gliomas is often palliative because of their infiltrating nature and high recurrence. Genetic events that lead to brain tumours are mostly unknown.
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Acta Neuropathologica, 1982
Fourteen juvenile patients with small cell gliomas were studied at two institutes. These tumors are believed to form a distinct entity. They arise mostly in the diencephalon or the brain stem and are composed of a poorly differentiated small cell component having a pronounced tendency to differentiate into a glioma.
R L, Friede, R C, Janzer, U, Roessmann
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Fourteen juvenile patients with small cell gliomas were studied at two institutes. These tumors are believed to form a distinct entity. They arise mostly in the diencephalon or the brain stem and are composed of a poorly differentiated small cell component having a pronounced tendency to differentiate into a glioma.
R L, Friede, R C, Janzer, U, Roessmann
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Cell kinetics of human gliomas
Journal of Neurosurgery, 1972✓ Eleven selected patients with brain tumor were given 3H-thymidine intravenously at the time of operation. Parts of the excised tumor were fixed for routine histological studies as well as for simple radioautography. Other parts were minced immediately after excision and incubated at 37°C with 14C-thymidine, and were thus doubly labeled.
T, Hoshino +4 more
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Mechanisms of glioma cell invasion
2003Invasive growth is one of the characteristics of gliomas--local infiltration into the surrounding nerve tissue decisively restricts all treatment strategies. Particularly the merit of all local treatment modalities is queried. The question whether a glioma represents a diffuse disease of the CNS or a local disturbance with unrestrained expansion ...
J C, Tonn, R, Goldbrunner
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2018
Stem cells (SC) are the seeds of tissue repair and regeneration that have been extensively investigated as tumor-tropic vectors for gene delivery to solid cancers. SC have an inherent glioma tropism that supports their use as reliable vehicles to deliver therapeutic gene products to brain neoplasms.
Brittany C, Parker Kerrigan +3 more
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Stem cells (SC) are the seeds of tissue repair and regeneration that have been extensively investigated as tumor-tropic vectors for gene delivery to solid cancers. SC have an inherent glioma tropism that supports their use as reliable vehicles to deliver therapeutic gene products to brain neoplasms.
Brittany C, Parker Kerrigan +3 more
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Targeting CXCR4 to suppress glioma‐initiating cells and chemoresistance in glioma
Cell Biology International, 2022AbstractGlioma initiating cells (GICs), also known as glioma stem cells, display the capacity to recapitulate the functional diversity within the tumor. Despite the great progress achieved over the last decades, defining the key molecular regulators of GICs has represented a major obstacle in this field.
Yao Wu +5 more
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Nature Clinical Practice Neurology, 2008
Despite continued advances in surgical and medical therapies, the outcomes for patients diagnosed with glioblastoma multiforme remain dismal. Recent data suggest that progression of these brain tumors is driven by a small subpopulation of tumor cells, which are termed cancer stem cells (CSCs) because of their capability to self-renew, proliferate and ...
Sunit, Das +2 more
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Despite continued advances in surgical and medical therapies, the outcomes for patients diagnosed with glioblastoma multiforme remain dismal. Recent data suggest that progression of these brain tumors is driven by a small subpopulation of tumor cells, which are termed cancer stem cells (CSCs) because of their capability to self-renew, proliferate and ...
Sunit, Das +2 more
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Markers of Stem Cells in Gliomas
2011Gliomas are the most common neoplasms of the Central Nervous System (CNS) and a frequent cause of mental impairment and death. Despite the improved responsiveness to primary therapy, survival of glioma patients is still very low. Therapies of malignant gliomas are often palliative because of their infiltrating nature and high recurrence.
Dell'Albani P +5 more
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Targeted Killing of Migrating Glioma Cells by Injection of HTK-Modified Glioma Cells
Human Gene Therapy, 1997The "bystander effect" describes the killing of nearby unmodified cells and herpes simplex thymidine kinase (HTK)-transduced cells by ganciclovir (GCV) treatment. This effect is thought to be produced by contact between these cells. In this study, we showed that injected glioma cells migrated rapidly to a place distant from the injection point whereas ...
M, Tamura +5 more
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