S100B inhibitor pentamidine attenuates reactive gliosis and reduces neuronal loss in a mouse model of Alzheimer's disease [PDF]
, 2015 Among the different signaling molecules released during reactive gliosis occurring in Alzheimer’s disease (AD), the astrocytederived S100B protein plays a key role in neuroinflammation, one of the hallmarks of the disease.
Capoccia, Elena +6 more
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Intravitreal slow-release dexamethasone alleviates traumatic proliferative vitreoretinopathy by inhibiting persistent inflammation and Müller cell gliosis in rabbits [PDF]
International Journal of Ophthalmology, 2023 AIM: To evaluate the effects of intravitreal slow-release dexamethasone on traumatic proliferative vitreoretinopathy (PVR) and Müller cell gliosis and preliminarily explored the possible inflammatory mechanism in a rabbit model induced by penetrating ...
Yi-Ming Zhao +8 more
doaj +3 more sources
Gpr37 modulates the severity of inflammation-induced GI dysmotility by regulating enteric reactive gliosis. [PDF]
iScienceRobertson K +13 more
europepmc +4 more sources
Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention [PDF]
Cancer Cell, 2019 Dominik Pfister +2 more
exaly +2 more sources
eLife, 2023 Mononuclear cells are involved in the pathogenesis of retinal diseases, including age-related macular degeneration (AMD). Here, we examined the mechanisms that underlie macrophage-driven retinal cell death. Monocytes were extracted from patients with AMD
Sarah Elbaz-Hayoun +4 more
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Biomedicines, 2023 Autism spectrum disorder (ASD) prevalence is emerging with an unclear etiology, hindering effective therapeutic interventions. Recent studies suggest potential renin–angiotensin system (RAS) alterations in different neurological pathologies. However, its
Ayat I. Samra +5 more
doaj +1 more source
Cholesterol and Alzheimer’s Disease; From Risk Genes to Pathological Effects
Frontiers in Aging Neuroscience, 2021 While the central nervous system compromises 2% of our body weight, it harbors up to 25% of the body’s cholesterol. Cholesterol levels in the brain are tightly regulated for physiological brain function, but mounting evidence indicates that excessive ...
Femke M. Feringa +3 more
doaj +1 more source
A novel P2X2‐dependent purinergic mechanism of enteric gliosis in intestinal inflammation
EMBO Molecular Medicine, 2020 Enteric glial cells (EGC) modulate motility, maintain gut homeostasis, and contribute to neuroinflammation in intestinal diseases and motility disorders.
Reiner Schneider +15 more
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Alterations of the Hippocampal Neurogenic Niche in a Mouse Model of Dravet Syndrome
Frontiers in Cell and Developmental Biology, 2020 Hippocampal neurogenesis, the process by which neural stem cells (NSCs) continuously generate new neurons in the dentate gyrus (DG) of most mammals including humans, is chiefly regulated by neuronal activity.
Soraya Martín-Suárez +6 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Hypoxia and hypoxia-reoxygenation are frequently developed through the course of many retinal diseases of different etiologies. Müller glial cells (MGCs), together with microglia and astrocytes, participate firstly in response to the injury and later in ...
Paula V. Subirada +11 more
doaj +1 more source