Results 11 to 20 of about 79,800 (306)

Anatomical Progression of Neuropathology in FTLD-TDP Type C and Linkage to Annexin A11. [PDF]

Ann Neurol
Objective Frontotemporal lobar degenerations (FTLD)‐TDP type C (TDP‐C) is distinguished from other FTLD‐TDP subtypes by 3 unique features: (1) invariable onset in the anterior temporal lobe (ATL), (2) phosphorylated TDP‐43 (pTDP) neurites in cortex, and (3) colocalization of all pTDP deposits with annexin A11 (ANXA11).
Kawles A, Nelson C, Ayala I, Barbieri E, Castellani R, Geula C, Gefen T, Mesulam MM.   +7 more
europepmc   +2 more sources

Antenatal Hypoxia Accelerates the Onset of Alzheimer’s Disease Pathology in 5xFAD Mouse Model

Frontiers in Aging Neuroscience, 2020
Alzheimer’s disease (AD) is a chronic neurodegenerative disorder associated with cognitive impairment and later dementia among the elderly. Mounting evidence shows that adverse maternal environments during the fetal development increase the risk of ...
Guofang Shen, Shirley Hu, Zhen Zhao, Lubo Zhang, Qingyi Ma   +4 more
doaj   +1 more source

Inflammation Mediated Epileptogenesis as Possible Mechanism Underlying Ischemic Post-stroke Epilepsy

Frontiers in Aging Neuroscience, 2021
Post-stroke Epilepsy (PSE) is one of the most common forms of acquired epilepsy, especially in the elderly population. As people get increasingly older, the number of stroke patients is expected to rise and concomitantly the number of people with PSE ...
Anna Regina Tröscher, Joachim Gruber, Joachim Gruber, Judith N. Wagner, Judith N. Wagner, Vincent Böhm, Vincent Böhm, Anna-Sophia Wahl, Anna-Sophia Wahl, Tim J. von Oertzen, Tim J. von Oertzen   +10 more
doaj   +1 more source

Peripheral and central effects of NADPH oxidase inhibitor, mitoapocynin, in a rat model of diisopropylfluorophosphate (DFP) toxicity

Frontiers in Cellular Neuroscience, 2023
Organophosphates (OP) are highly toxic chemical nerve agents that have been used in chemical warfare. Currently, there are no effective medical countermeasures (MCMs) that mitigate the chronic effects of OP exposure.
Christina Meyer, Nikhil S. Rao, Suraj S. Vasanthi, Beatriz Pereira, Meghan Gage, Marson Putra, Claire Holtkamp, Joselyn Huss, Thimmasettappa Thippeswamy   +8 more
doaj   +1 more source

CD8 T-cell Recruitment Into the Central Nervous System of Cuprizone-Fed Mice: Relevance to Modeling the Etiology of Multiple Sclerosis

Frontiers in Cellular Neuroscience, 2020
Cuprizone (CPZ)-feeding in mice induces atrophy of peripheral immune organs (thymus and spleen) and suppresses T-cell levels, thereby limiting its use as a model for studying the effects of the immune system in demyelinating diseases such as Multiple ...
Mohammed S. M. Almuslehi, Mohammed S. M. Almuslehi, Monokesh K. Sen, Peter J. Shortland, David A. Mahns, Jens R. Coorssen, Jens R. Coorssen   +6 more
doaj   +1 more source

Multiple indices of diffusion identifies white matter damage in mild cognitive impairment and Alzheimer's disease [PDF]

, 2010
The study of multiple indices of diffusion, including axial (DA), radial (DR) and mean diffusion (MD), as well as fractional anisotropy (FA), enables WM damage in Alzheimer's disease (AD) to be assessed in detail.
Bartley, Máiréad, Bokde, Arun L. W., Collins, D. Rónán, Coughlan, Tara, Ewers, Michael, Faluyi, Yetunde O., Hampel, Harald, Lamberton, Franck, Mazoyer, Bernard M., O'Dwyer, Laurence, O'Neill, Des, Prvulovic, David, Tanner, Colby   +12 more
core   +6 more sources

Neuroprotection by upregulation of the major histocompatibility complex class I (MHC I) in SOD1G93A mice

Frontiers in Cellular Neuroscience, 2023
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that progressively affects motoneurons, causing muscle atrophy and evolving to death. Astrocytes inhibit the expression of MHC-I by neurons, contributing to a degenerative outcome.
Ana Laura M. R. Tomiyama, Luciana Politti Cartarozzi, Lilian de Oliveira Coser, Gabriela Bortolança Chiarotto, Alexandre L. R. Oliveira   +4 more
doaj   +1 more source

Müller glia activation in response to inherited retinal degeneration is highly varied and disease-specific [PDF]

, 2015
Despite different aetiologies, most inherited retinal disorders culminate in photoreceptor loss, which induces concomitant changes in the neural retina, one of the most striking being reactive gliosis by Müller cells.
Ali, RR, Barber, AC, Graca, AB, Hippert, C, Pearson, RA, Smith, AJ, West, EL   +6 more
core   +1 more source

Reduced neurosteroid potentiation of GABAA receptors in epilepsy and depolarized hippocampal neurons [PDF]

, 2020
OBJECTIVE: Neurosteroids regulate neuronal excitability by potentiating γ-aminobutyric acid type-A receptors (GABARs). In animal models of temporal lobe epilepsy, the neurosteroid sensitivity of GABARs is diminished and GABAR subunit composition is ...
Jansen, Laura A, Joshi, Suchitra, Kapur, Jaideep, Roden, William H   +3 more
core   +2 more sources

Trends in Gliosis in Obesity, and the Role of Antioxidants as a Therapeutic Alternative

Antioxidants, 2022
Obesity remains a global health problem. Chronic low-grade inflammation in this pathology has been related to comorbidities such as cognitive alterations that, in the long term, can lead to neurodegenerative diseases.
Cindy Bandala, Noemi Cárdenas-Rodríguez, Samuel Reyes-Long, José Luis Cortes-Altamirano, David Garciadiego-Cázares, Eleazar Lara-Padilla, Gabriela Ibáñez-Cervantes, Javier Mancilla-Ramírez, Saul Gómez-Manzo, Alfonso Alfaro-Rodríguez   +9 more
doaj   +1 more source