Results 31 to 40 of about 79,800 (306)

Targeting neuroinflammation in Alzheimer’s disease [PDF]

, 2016
Almost 47 million people suffer from dementia worldwide, with an estimated new case diagnosed every 3.2 seconds. Alzheimer’s disease (AD) accounts for approximately 60%–80% of all dementia cases. Given this evidence, it is clear dementia represents one
Bronzuoli, MARIA ROSANNA, Iacomino, Aniello, Scuderi, Caterina, Steardo, Luca   +3 more
core   +1 more source

Adaptive Müller cell responses to microglial activation mediate neuroprotection and coordinate inflammation in the retina

Journal of Neuroinflammation, 2011
Purpose Microglia and Müller cells are prominent participants in retinal responses to injury and disease that shape eventual tissue adaptation or damage.
Wang Minhua, Ma Wenxin, Zhao Lian, Fariss Robert N, Wong Wai T   +4 more
doaj   +1 more source

A Comparative Analysis of Gene and Protein Expression Throughout a Full 28-Day Retinal Regeneration Time-Course in Adult Zebrafish

Frontiers in Cell and Developmental Biology, 2021
Following photoreceptors ablation by intense light exposure, adult zebrafish are capable of complete regeneration due to the ability of their Müller glia (MG) to re-enter the cell cycle, creating progenitors that differentiate into new photoreceptors ...
Ashley C. Kramer, Katherine Gurdziel, Ryan Thummel   +2 more
doaj   +1 more source

Multiplex ligation-dependent probe amplification (MLPA) analysis is an effective tool for the detection of novel intragenic PLA2G6 mutations: Implications for molecular diagnosis [PDF]

, 2010
Phospholipase associated neurodegeneration (PLAN) comprises a heterogeneous group of autosomal recessive neurological disorders caused by mutations in the PLA2G6 gene. Direct gene sequencing detects 85% mutations in infantile neuroaxonal dystrophy.
Brady, Angela F, Crompton, Danielle, De Gressi, Susanna, Foster, Kathleen, Hardy, Carol, Hughes, Imelda, Kurian, Manju A, Lunt, Peter, MacPherson, Lesley, Maher, Eamonn R, McDonald, Fiona, Morgan, Neil V, Pike, Michael G, Rehal, Pauline K, Smith, Matthew   +14 more
core   +1 more source

Bi-allelic JAM2 Variants Lead to Early-Onset Recessive Primary Familial Brain Calcification. [PDF]

, 2020
Primary familial brain calcification (PFBC) is a rare neurodegenerative disorder characterized by a combination of neurological, psychiatric, and cognitive decline associated with calcium deposition on brain imaging. To date, mutations in five genes have
A. Athanasiou-Fragkouli, A. Begtrup, A. Bisgin, A. Carr, A. Pittman, A. Richard-Loendt, A. Verrotti, A.M. Ruiz, B. Cormand, B. Garavaglia, B. Kalmar, B. O&apos, B. Perez-Duenas, B.M. Karashova, B.M. Sanchez, C. Beetz, C. Macmillan, C. Scuderi, D. Avdjieva, D. Timmann, E. Borgione, E. Dardiotis, E. Torti, E.Z. Papanicolaou, F. Al-Mutairi, F. Launchbury, G. Di Rosa, G. Heimer, G. Hotton, G. Koutsis, G. Marseglia, G. McDonnell, G. Morello, H. Houlden, H. Kathom, H. Sherifa, I. Al-Khawaja, J. Althonayan, J. McKinley, J. Mine, J.H. Livingston, J.R. Mendes de Oliveira, J.S. Goraya, L. Arning, L. Greensmith, L.V. Schottlaender, M. Aurrand-Lions, M. Breza, M. de Grandis, M. Garcia-Silva, M. Pineda-Marfa, M. Vikelis, M. Zollo, M.D. Ferrari, M.P.M. Soutar, N.N. Rana, O. Atawneh, O. Swayne, P. Giunti, P. Striano, P. Veggiotti, P.J. Morrison, R. Abeti, R. Boles, R. Forbes, R. Maroofian, R. Tincheva, S. Banu, S. Boesch, S. Brandner, S. Efthymiou, S. Groppa, S. Ibrahim, S. Khan, S. Kirmani, S. Mangano, S. Maqbool, S. Papacostas, S. Portaro, S. Savasta, S. Tug Bozdogan, T. Stojkovic, T. Sultan, V. Chelban, W. Nachbauer, Y.A. Dauvilliers, Z. Jaunmuktane   +86 more
core   +8 more sources

Differential Expression of Kinin Receptors in Human Wet and Dry Age-Related Macular Degeneration Retinae

Pharmaceuticals, 2020
Kinins are vasoactive peptides and mediators of inflammation, which signal through two G protein-coupled receptors, B1 and B2 receptors (B1R, B2R). Recent pre-clinical findings suggest a primary role for B1R in a rat model of wet age-related macular ...
Rahmeh Othman, Simon Berbari, Elvire Vaucher, Réjean Couture   +3 more
doaj   +1 more source

Febrile Seizure Causes Deficit in Social Novelty, Gliosis, and Proinflammatory Cytokine Response in the Hippocampal CA2 Region in Rats

Cells, 2023
Febrile seizure (FS), which occurs as a response to fever, is the most common seizure that occurs in infants and young children. FS is usually accompanied by diverse neuropsychiatric symptoms, including impaired social behaviors; however, research on ...
Yeon Hee Yu, Seong-Wook Kim, Hyuna Im, Yu Ran Lee, Gun Woo Kim, Seongho Ryu, Dae-Kyoon Park, Duk-Soo Kim   +7 more
doaj   +1 more source

The Zebrafish as a Model for Ocular Translational Research: From Retinal Repair to Regeneration

Cells
In the last years, the zebrafish model has become a primary model system for vertebrate tissue regeneration, particularly for neurodegeneration and metabolic disease.
Bijorn Omar Balzamino, Mariagrazia Severino, Concetta Cafiero, Marco Coassin, Antonio Di Zazzo, Alessandra Micera   +5 more
doaj   +1 more source

Release of VAMP5‐positive extracellular vesicles by retinal Müller glia in vivo

Journal of Extracellular Vesicles, 2022
Cell‐cell interactions in the central nervous system are based on the release of molecules mediating signal exchange and providing structural and trophic support through vesicular exocytosis and the formation of extracellular vesicles.
Valerie Demais, Anne Pohl, Kirsten A. Wunderlich, Anna M. Pfaller, Lew Kaplan, Amelie Barthélémy, Robin Dittrich, Berta Puig, Bernd Giebel, Stefanie M. Hauck, Frank W. Pfrieger, Antje Grosche   +11 more
doaj   +1 more source

How Is Peripheral Injury Signaled to Satellite Glial Cells in Sensory Ganglia?

Cells, 2022
Injury or inflammation in the peripheral branches of neurons of sensory ganglia causes changes in neuronal properties, including excessive firing, which may underlie chronic pain.
Menachem Hanani
doaj   +1 more source