Results 81 to 90 of about 79,800 (306)

Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration [PDF]

, 2015
Acknowledgements We are indebted to Jim Humphries, JennyCorrigan, LizDarley, Elizabeth Joynson, Natalie Walters, Sara Wells and the whole necropsy, histology, genotyping and MLC ward 6 teams at MRC Harwell for excellent technical assistance. We thank the
Abramov, Andrey Y., Acevedo-Arozena, Abraham, Bennet, David L. H., Beskina, Olga A., Brandner, Sebastian, Busam, Bharani Shiva, Carter, Sarah, Codner, Gemma, Corrochano, Silvia, Esapa, Christopher, Estabel, Jeanne, Fisher, Elizabeth M. C., Fratta, Pietro, Galino, Jorge, Greensmith, Linda, Groves, Michael, Hilton, Helen, Joyce, Peter I., Landman, Allison S., Lionikas, Arimantas, Mcgoldrick, Philip, Plagnol, Vincent, Ramirez-Solis, Ramiro, Ryder, Edward, Stewart, Michelle, Teboul, Lydia, Tucker, Jennifer, Wackerhage, Henning, White, Jacqueline K.   +28 more
core   +3 more sources

Recombinant Integrin β1 Signal Peptide Blocks Gliosis Induced by Aβ Oligomers [PDF]

, 2022
Carolina Ortiz-Sanz, Francisco Llavero, Jone Zuazo-Ibarra, Uxue Balantzategi, Tania Quintela‐López, Ane Wyssenbach, Estibaliz Capetillo‐Zarate, Carlos Matute, Elena Alberdi, José L. Zugaza   +9 more
openalex   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Early exposure to environmental toxin contributes to neuronal vulnerability and axonal pathology in a model of familial ALS [PDF]

, 2011
Adult onset amyotrophic lateral sclerosis (ALS) arises due to progressive and irreversible functional deficits to the central nervous system, specifically the loss of motor neurons.
Christopher A. Shaw, Grace Lee
core   +1 more source

A Blood‐Brain Barrier‐Penetrant Ag(III) Corrole Compound Rescues Alzheimer's Disease Pathology by Targeting Aβ42‐Induced Oxidative Stress

Advanced Science, EarlyView.
The newly designed metallo‐corrole (Mor‐Cor)Ag(III) with a morpholino group exhibited promising therapeutic potential for Alzheimer's disease. It significantly reduces reactive oxygen species (ROS), decreases GFAP expression, increases neurite length, and decreases cell death compared to other similar metallo‐corroles. Abstract Alzheimer's disease (AD)
Arup Tarai, Tuhina Mitra, Tanmoy Pain, Jyotiprakash Mallick, Rwiddhi Chakraborty, Kallam Tejaswi, Swagata Ghatak, Sanjib Kar   +7 more
wiley   +1 more source

Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer’s disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis [PDF]

, 2021
Hei-Jen Huang, Jie-Ling Chen, Jian-Fu Liao, Yu‐Hsin Chen, Min-Wei Chieu, Ya-Yun Ke, Chih-Chieh Hsu, Ying-Chieh Tsai, Hsiu Mei Hsieh‐Li   +8 more
openalex   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

A Case of Multiple Sclerosis Presenting as Eight and Half Syndrome. [PDF]

, 2013
Multiple sclerosis (MS) is a chronic disease characterized by inflammation, demyelination, gliosis (scarring), and neuronal loss; the course can be relapsing-remitting or progressive.
Kaushik, M, Mahajan, SK, Raghav, S, Raina, R, Sharathbabu, NM   +4 more
core  

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy [PDF]

, 2017
Significance Alzheimer’s disease (AD) is the most common cause of dementia and is a major public health problem for which there is currently no disease-modifying treatment.
Anderson, Elise, Colonna, Marco, Finn, Mary B., Holtzmann, David M., Koscal, Lauren J., Leyns, Cheryl E. G., Robinson, Grace O., Serrano, Javier Remolina, Stewart, Floy R., Ulrich, Jason D.   +9 more
core   +2 more sources

Insights into organelle forming RNAs: Diversity, functions and future perspectives

Animal Models and Experimental Medicine, EarlyView.
RNA molecules play crucial roles in the formation and maintenance of cellular structures and organelles. These ‘organelle formation RNAs’ include ribosomal RNAs, paraspeckle‐forming RNAs, nuclear speckle‐forming RNAs, nucleolus‐forming RNAs, and cytoskeleton‐forming RNA.
Meng Gong, Xiangting Wang, Xiaolin Liang
wiley   +1 more source