Results 31 to 40 of about 11,103,208 (288)

Priority research questions for the UK food system [PDF]

, 2013
The rise of food security up international political, societal and academic agendas has led to increasing interest in novel means of improving primary food production and reducing waste.
Ingram, John S I, Tassou, S., Benton, Tim G., Miller, Anne, Dolan, Catherine S, Sutherland, William J, Timothy Aldred, Knox, J. W., Kaiser, M.J., Norton, Ian T., Macdiarmid, Jennie I, Fitzpatrick, JL, Quested, TE, Murray, C, Kennard, R., Crossley, Daniel S., McGonigle, D.F., Macdiarmid, Jennie I., Terry, L. A., Murray, Calum, Finney, K. J., Ian T. Norton, Brocklehurst, Tim F., Leon A. Terry, Judith Buttriss, Millar, S.J., Brocklehurst, Tim F, Mead, Angela, Terry, Leon A, John Casey, William Vorley, Charles S. Bestwick, Benton, T.G., Crossley, D.S., Kuyk, A., Jennie I. Macdiarmid, Buttriss, J, Kuyk, A, Wright, HL, Bows-Larkin, A., Crossley, D. S., Martindale, Wayne, Brocklehurst, T. F., Garrett, D.A., Kaiser, Michel J.; id_orcid, Stephen Parry, Kennard, Robert, Foster, Lucy, Houlston, Eleanor J, Fowler, M., Dolan, C.S., Buttriss, Judith, Mathers, J. C., Daniel S. Crossley, Benton, Tim G, Mead, A., Alice Bows-Larkin, Kaiser, Michel J, Mathers, J.C., David Barling, Catherine S. Dolan, Houlston, EJ, McGonigle, Daniel F., Finney, Karen J, Mead, A, Marilena Pollicino, Garrett, David A., Murray, C., Aldred, Timothy, Michel J. Kaiser, Ingram, J. S. I., Norton, I.T., Hugh L. Wright, Millar, Samuel J, Andrew Kuyk, Edwards, R., Casey, J, Linter, B.R., Fowler, M, van de Graaf, P., Vorley, W., Bows-Larkin, Alice; id_orcid, Aldred, T., Paul M. Berryman, Tiffin, R, Parry, S., Macdiarmid, JI, Foster, L, Andrew Godley, Calum Murray, Martindale, W., Fitzpatrick, J.L., Pollicino, Marilena, Berryman, Paul M, Robert Edwards, Collins, H, Finney, KJ, Quested, Thomas E, McGonigle, DF, Griffiths, W., Martindale, W, Garrett, David A, Dowler, Elizabeth, Fowler, Mark, Linter, Bruce R, Angela Mead, Fitzpatrick, J. L., Edwards, Robert, Norton, I. T., Millar, Samuel J., Thomas E. Quested, Robert Kennard, Bestwick, C. S., Vorley, William, Ingram, JSI, Tim G. Benton, Barling, D., Sutherland, William J., Dolan, Catherine S., Brocklehurst, T.F., Godfrey, J.E., McGonigle, Daniel F, Tassou, S, Jim E. Godfrey, Linter, B. R., Macdiarmid, J.I., William J. Sutherland, Terry, L.A., Godley, A., Kaiser, Michel J., Casey, J., Karen J. Finney, Julie L. Fitzpatrick, Wright, Hugh, Wright, H.L., Vorley, W, Aldred, Tim, Andrew Westby, Mathers, JC, Knox, Jerry W, Mathers, John C, Miller, A., Godley, A, Casey, John, Ingram, John S. I., Berryman, P.M., et, al, Finney, Karen J., Dowler, E, Fitzpatrick, Julie L, Garrett, DA, Graaf, P, Wright, H. L., Godfrey, Jim E, Elizabeth Dowler, David A. Garrett, Bestwick, Charles S, Bows-Larkin, Alice, McGonigle, D. F., Westby, A, Crossley, Daniel S, Houlston, E.J., Eleanor J. Houlston, Dowler, E., Berryman, PM, Finney, K.J., Crossley, DS, Kennard, R, Macdiarmid, J. I., Benton, T., Quested, T.E., John S. I. Ingram, Benton, TG, Brocklehurst, TF, Foster, L., Tiffin, R., Norton, Ian T, Dolan, CS, Godley, Andrew, Pollicino, M., Griffiths, William, William Griffiths, Barling, David, Linter, BR, Pieter van de Graaf, Parry, S, Ingram, J.S.I., Wright, Hugh L, Aldred, T, van de Graaf, Pieter, Sutherland, WJ, Lucy Foster, Westby, A., Bows-Larkin, A, Knox, J.W., Norton, IT, Millar, SJ, Knox, JW, Tim F. Brocklehurst, Graaf, P., Knox, Jerry W., Kuyk, Andrew, Tassou, Savvas, Dolan, C. S., Collins, Hannah, Mathers, John C., Wright, Hugh L., Collins, H., Sutherland, W. J., Pieter, van de Graaf, Samuel J. Millar, Dolan, Catherine, Godfrey, Jim E., Bestwick, CS, Houlston, Eleanor J., Kaiser, MJ, Bestwick, C.S., Daniel F. McGonigle, Ingram, John S.I., Berryman, Paul M., John C. Mathers, Anne Miller, Parry, Stephen, Sutherland, W.J., Buttriss, J., Berryman, P. M., Linter, Bruce R., Quested, Thomas E., Savvas Tassou, Godfrey, JE, Richard Tiffin, Wayne Martindale, Miller, A, Terry, LA, Fitzpatrick, Julie L., Barling, D, Griffiths, W, Edwards, R, Millar, S. J., Tiffin, Richard, Jerry W. Knox, Godley, Andrew R., Terry, Leon A., Pollicino, M, Hannah Collins, Bruce R. Linter, Ingram, John, Bestwick, Charles S., Mark Fowler, Westby, Andrew   +249 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Challenges and strategies to combat global iron deficiency by food fortification

Ceylon Journal of Science, 2016
Iron is an important micronutrient required for healthy living. Therefore, populations dependent primarily on plant-based diets with little or no animal flesh may become deficient in iron.
R. M. P. I. Rajakaruna, Isuru R. Ariyarathna, D. Nedra Karunaratne   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Agriculture, food security, and sustainability: a review [PDF]

Exploration of Foods and Foodomics
Agriculture is pivotal in securing global food security and sustainability, especially in pressing challenges such as climate change, population growth, and resource depletion. This review examines the interconnections between agriculture, food security,
Shahidul Islam
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source