Results 51 to 60 of about 1,374,388 (308)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The Challenges and Strategies of Food Security under Global Change

Foods
Food insecurity corresponds to a deficit in households’ access to appropriate food, either in quantity and/or quality, due to limited financial resources or other factors [...]
Raquel P. F. Guiné
doaj   +1 more source

Feeding Ourselves Thirsty: How the Food Sector is Managing Global Water Risks [PDF]

, 2015
The global food sector faces extraordinary risks from the twin challenges of water scarcity and water pollution. Growing competition for water, combined with weak regulations, failing infrastructure, pollution and climate change impacts threaten the ...
Brooke Barton, Eliza Roberts
core  

Aquatic food security:insights into challenges and solutions from an analysis of interactions between fisheries, aquaculture, food safety, human health, fish and human welfare, economy and environment [PDF]

, 2016
Fisheries and aquaculture production, imports, exports and equitability of distribution determine the supply of aquatic food to people. Aquatic food security is achieved when a food supply is sufficient, safe, sustainable, shockproof and sound ...
AB Associates, Agnew D.J., Allison E.H., Anon, Anon, Bagnis R., Black K.D., Braithwaite V., CDC, EA, FSA, NIEA, NRW and SEPA, EC, EC, EC, EC, EC, EC, EC, EC, EC, EC, EC, EC, EC, Ellis T., Enghoff I.B., European Food Safety Authority, European Market Observatory for Fisheries and Aquaculture Products, FAO, FAO, FAO, FAO, FAO, Farm Animal Welfare Committee, FDA, Food Standards Agency, Garcia S.M., Gil A., Hall S.J., Hallegraef G.M., Hart P.J., Health and Safety Executive, Health and Safety Executive, Higman W.A., Hixson S.M., ICES, IMF, International Labour Organisation, James M.A., Lambie‐Mumford H., Lambooija E., Maritime Accident Investigation Branch, Morgan O., National Crime Agency, National Toxicology Program, Neil D., Nesheim M.C., Papworth G.P., PHE‐FSA, Robb D.F.H., Roberts S.E., Roth B., Sainsbury's Supermarkets, Scientific Advisory Committee on Nutrition and Committee on Toxicity, Scottish Government, Seafish, Seafish, Seafish, Shepherd C.J., SOCA, STECF, STECF, Trussell Trust, Turner R.K., Turner R.K., UK Government, UK Government, UK Government, UK Government, UK Government, UK Government, UK Government, UK Government, Verner‐Jeffreys D.W., Warner K., World Commission on Environment and Development, World Health Organization   +85 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Towards a new generation of (agri-) food policies

Bio-based and Applied Economics, 2023
The succession of systemic crises in the last 20 years has affected our lives and has shaken the old order. The global community, represented by UN-based institutions, has encouraged a common effort to address global challenges. In the agri-food sector,
GIANLUCA BRUNORI
doaj   +1 more source

ENSURING FOOD SECURITY UNDER GLOBAL CHALLENGES

Bioeconomics and Agrarian Business
The article is aimed at assessing the state of food security of Ukraine. The level of food security in Ukraine is checked according to the internal system of parameters and international methodologies. Analysis of the level of food security in Ukraine by the Global Food Security Index shows that it lags far behind not only the leading countries but ...
Viktoriia Baidala, Anna Yakymovska
openaire   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source