Results 41 to 50 of about 11,797,362 (298)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Priority research questions for the UK food system [PDF]

, 2013
The rise of food security up international political, societal and academic agendas has led to increasing interest in novel means of improving primary food production and reducing waste.
Ingram, John S I, Tassou, S., Benton, Tim G., Miller, Anne, Dolan, Catherine S, Sutherland, William J, Timothy Aldred, Knox, J. W., Kaiser, M.J., Norton, Ian T., Macdiarmid, Jennie I, Fitzpatrick, JL, Quested, TE, Murray, C, Kennard, R., Crossley, Daniel S., McGonigle, D.F., Macdiarmid, Jennie I., Terry, L. A., Murray, Calum, Finney, K. J., Ian T. Norton, Brocklehurst, Tim F., Leon A. Terry, Judith Buttriss, Millar, S.J., Brocklehurst, Tim F, Mead, Angela, Terry, Leon A, John Casey, William Vorley, Charles S. Bestwick, Benton, T.G., Crossley, D.S., Kuyk, A., Jennie I. Macdiarmid, Buttriss, J, Kuyk, A, Wright, HL, Bows-Larkin, A., Crossley, D. S., Martindale, Wayne, Brocklehurst, T. F., Garrett, D.A., Kaiser, Michel J.; id_orcid, Stephen Parry, Kennard, Robert, Foster, Lucy, Houlston, Eleanor J, Fowler, M., Dolan, C.S., Buttriss, Judith, Mathers, J. C., Daniel S. Crossley, Benton, Tim G, Mead, A., Alice Bows-Larkin, Kaiser, Michel J, Mathers, J.C., David Barling, Catherine S. Dolan, Houlston, EJ, McGonigle, Daniel F., Finney, Karen J, Mead, A, Marilena Pollicino, Garrett, David A., Murray, C., Aldred, Timothy, Michel J. Kaiser, Ingram, J. S. I., Norton, I.T., Hugh L. Wright, Millar, Samuel J, Andrew Kuyk, Edwards, R., Casey, J, Linter, B.R., Fowler, M, van de Graaf, P., Vorley, W., Bows-Larkin, Alice; id_orcid, Aldred, T., Paul M. Berryman, Tiffin, R, Parry, S., Macdiarmid, JI, Foster, L, Andrew Godley, Calum Murray, Martindale, W., Fitzpatrick, J.L., Pollicino, Marilena, Berryman, Paul M, Robert Edwards, Collins, H, Finney, KJ, Quested, Thomas E, McGonigle, DF, Griffiths, W., Martindale, W, Garrett, David A, Dowler, Elizabeth, Fowler, Mark, Linter, Bruce R, Angela Mead, Fitzpatrick, J. L., Edwards, Robert, Norton, I. T., Millar, Samuel J., Thomas E. Quested, Robert Kennard, Bestwick, C. S., Vorley, William, Ingram, JSI, Tim G. Benton, Barling, D., Sutherland, William J., Dolan, Catherine S., Brocklehurst, T.F., Godfrey, J.E., McGonigle, Daniel F, Tassou, S, Jim E. Godfrey, Linter, B. R., Macdiarmid, J.I., William J. Sutherland, Terry, L.A., Godley, A., Kaiser, Michel J., Casey, J., Karen J. Finney, Julie L. Fitzpatrick, Wright, Hugh, Wright, H.L., Vorley, W, Aldred, Tim, Andrew Westby, Mathers, JC, Knox, Jerry W, Mathers, John C, Miller, A., Godley, A, Casey, John, Ingram, John S. I., Berryman, P.M., et, al, Finney, Karen J., Dowler, E, Fitzpatrick, Julie L, Garrett, DA, Graaf, P, Wright, H. L., Godfrey, Jim E, Elizabeth Dowler, David A. Garrett, Bestwick, Charles S, Bows-Larkin, Alice, McGonigle, D. F., Westby, A, Crossley, Daniel S, Houlston, E.J., Eleanor J. Houlston, Dowler, E., Berryman, PM, Finney, K.J., Crossley, DS, Kennard, R, Macdiarmid, J. I., Benton, T., Quested, T.E., John S. I. Ingram, Benton, TG, Brocklehurst, TF, Foster, L., Tiffin, R., Norton, Ian T, Dolan, CS, Godley, Andrew, Pollicino, M., Griffiths, William, William Griffiths, Barling, David, Linter, BR, Pieter van de Graaf, Parry, S, Ingram, J.S.I., Wright, Hugh L, Aldred, T, van de Graaf, Pieter, Sutherland, WJ, Lucy Foster, Westby, A., Bows-Larkin, A, Knox, J.W., Norton, IT, Millar, SJ, Knox, JW, Tim F. Brocklehurst, Graaf, P., Knox, Jerry W., Kuyk, Andrew, Tassou, Savvas, Dolan, C. S., Collins, Hannah, Mathers, John C., Wright, Hugh L., Collins, H., Sutherland, W. J., Pieter, van de Graaf, Samuel J. Millar, Dolan, Catherine, Godfrey, Jim E., Bestwick, CS, Houlston, Eleanor J., Kaiser, MJ, Bestwick, C.S., Daniel F. McGonigle, Ingram, John S.I., Berryman, Paul M., John C. Mathers, Anne Miller, Parry, Stephen, Sutherland, W.J., Buttriss, J., Berryman, P. M., Linter, Bruce R., Quested, Thomas E., Savvas Tassou, Godfrey, JE, Richard Tiffin, Wayne Martindale, Miller, A, Terry, LA, Fitzpatrick, Julie L., Barling, D, Griffiths, W, Edwards, R, Millar, S. J., Tiffin, Richard, Jerry W. Knox, Godley, Andrew R., Terry, Leon A., Pollicino, M, Hannah Collins, Bruce R. Linter, Ingram, John, Bestwick, Charles S., Mark Fowler, Westby, Andrew, Barling, D.B., Wright H.L., Crossley, D.H.   +252 more
core   +1 more source

Food Safety Management Systems in International Food Chain Facilities: Global Practices and Local Challenges

ეკონომიკური პროფილი
Food safety is one of the main socio-political and economic issues of modern society. It is considered one of the main elements of national and global security and an important indicator of economic development and well-being.
Mariam Gonjilashvili, Giorgi Kepuladze
doaj   +1 more source

Sustainability of Food Systems: The Role of Food Technology and Regulatory Science [PDF]

BIO Web of Conferences
Food systems encompass complex and interconnected networks involved in the production, processing, distribution, and consumption of food. Currently, the food system confronts significant challenges related to the environment, society, and economy. A 2023
Hariyadi Purwiyatno
doaj   +1 more source

Civil society challenges the global food system: the International Monsanto Tribunal [PDF]

Globalizations, 2019
The global food system has severe implications for human health, soil quality, biodiversity, and quality of life. This paper provides an analysis on how transnational alliances challenge the global food system. We illustrate this byfocusing on the activities and hearings of the International Monsanto Tribunal (IMT), held in the Hague in 2016.
Nienke Busscher, Eva Lia Colombo, Lidewij van der Ploeg, Julia Inés Gabella, Amalia Leguizamón   +4 more
openaire   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

2011 Global food policy report

The year 2011 highlighted ongoing challenges to global food security, from food price volatility, extreme weather shocks, and famine to unrest and conflicts.
International Food Policy Research Institute
core   +1 more source