Evolutionary Constraints in the b-Globin Cluster: The Signature of Purifying Selection at the d-Globin (HBD) Locus and Its Role in Developmental Gene Regulation [PDF]
, 2013 Human hemoglobins, the oxygen carriers in the blood, are composed by two α-like and two β-like globin monomers. The β-globin gene cluster located at 11p15.5 comprises one pseudogene and five genes whose expression undergoes two critical switches: the ...
Amorim, A +5 more
core
ChemistryEurope, Volume 4, Issue 1, January 2026.Direct air capture (DAC) of carbon dioxide (CO2) emerges as a key strategy for climate crisis mitigation. Redox‐mediated electrochemical carbon capture offers a promising route for energy‐efficient DAC. This perspective discusses recent advances in the field, highlighting key challenges, such as oxygen interference at low CO2 concentrations, and ...
Tilmann J. Neubert, Martin Oschatz
wiley +1 more source
Non-Viral Episomal Vector Mediates Efficient Gene Transfer of the β-Globin Gene into K562 and Human Haematopoietic Progenitor Cells [PDF]
, 2023 Vasileios Lazaris +7 more
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Pulmonary hypertension in adolescents with sickle cell disease [PDF]
, 2016 Sickle cell disease consists of a group of disorders that have a similar mutation in at least one of the beta-globin chains of hemoglobin. This results in a change of the hemoglobin to sickle shaped cells when in the deoxygenated state.
Akinyemi, Katherine
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HemaSphere, Volume 10, Issue 1, January 2026.ABSTRACT Administration of memantine, an antagonist of the N‐methyl‐ d‐aspartate receptor, prevents Ca2+ overload and dehydration of red blood cells (RBCs) in patients with sickle cell disease (SCD). The objectives of the 1‐year dose‐escalation Phase IIa/IIb Memantine trial (MeMAGEN – NCT 03247218) with 17 SCD patients who were under stable ...
Ariel Koren +7 more
wiley +1 more source
An in Vitro Investigation of Globin Folding and Expression [PDF]
, 2016 Premila P. Samuel +3 more
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Erythropoiesis in health and disease: Distinguishing defective and ineffective erythropoiesis
HemaSphere, Volume 10, Issue 1, January 2026.Abstract Erythropoiesis is a finely regulated process ensuring continuous red blood cell production to maintain oxygen delivery. Disruptions in this process give rise to defective erythropoiesis, characterized by impaired lineage commitment and progenitor development, and ineffective erythropoiesis (IE), marked by expansion of erythroid progenitors ...
Sara El Hoss +3 more
wiley +1 more source
Transcription of the αA‐globin gene of the duck [PDF]
, 1989 Sabine WEINGART +3 more
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A Rational Approach to Pharmacotherapy in Pregnancy
The Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.Abstract Most pregnant individuals are exposed to at least one medication, whether prescription or over the counter, during pregnancy. Despite the ubiquity of medication use in pregnancy, there remains no standardized framework to guide clinicians in selecting the most appropriate pharmacotherapy that balances maternal needs with fetal safety. This gap
Gregory W. Kirschen +2 more
wiley +1 more source
549 VISUALIZATION OF HUMAN GLOBIN GENES BY RESTRICTION ENDONUCLEASE MAPPING: A NEW APPROACH TO THE PRENATAL DIAGNOSIS OF GLOBIN GENE DELETION [PDF]
, 1978 Stuart H. Orkin, David G. Nathan
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