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Globin Associated Oxidative Stress [PDF]
Antioxidants, 2023 Globins have been studied for their “pseudo-peroxidase” activity for over 70 years, being an ideal model of other kinetically more rapid metalloenzymes [...]
Brandon J. Reeder
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Neuroglobin and Cytoglobin in Mammalian Nervous Systems: About Distribution, Regulation, Function, and Some Open Questions [PDF]
Brain SciencesGlobins are a class of globular proteins that function in the transportation or storage of oxygen. They are critical for cellular metabolism. Notable examples include hemoglobin, which is found in red blood cells, and myoglobin, which is present in ...
Stefan Reuss
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Redox Reactivity of Nonsymbiotic Phytoglobins towards Nitrite [PDF]
MoleculesNonsymbiotic phytoglobins (nsHbs) are a diverse superfamily of hemoproteins grouped into three different classes (1, 2, and 3) based on their sequences.
Cezara Zagrean-Tuza +4 more
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Nitric Oxide and Globin Glb1 Regulate Fusarium oxysporum Infection of Arabidopsis thaliana
Antioxidants, 2023 Plants continuously interact with fungi, some of which, such as Fusarium oxysporum, are lethal, leading to reduced crop yields. Recently, nitric oxide (NO) has been found to play a regulatory role in plant responses to F.
Laura C. Terrón-Camero +4 more
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A phylogenetic analysis of the globins in fungi. [PDF]
PLoS ONE, 2012 BackgroundAll globins belong to one of three families: the F (flavohemoglobin) and S (sensor) families that exhibit the canonical 3/3 α-helical fold, and the T (truncated 3/3 fold) globins characterized by a shortened 2/2 α-helical fold.
David Hoogewijs +4 more
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Ligand-Based Regulation of Dynamics and Reactivity of Hemoproteins
Biomolecules, 2023 Hemoproteins include several heme-binding proteins with distinct structure and function. The presence of the heme group confers specific reactivity and spectroscopic properties to hemoproteins.
Emily Samuela Turilli-Ghisolfi +2 more
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CRISPR-Cas9 to induce fetal hemoglobin for the treatment of sickle cell disease
Molecular Therapy: Methods & Clinical Development, 2021 Genome editing is potentially a curative technique available to all individuals with β-hemoglobinopathies, including sickle cell disease (SCD). Fetal hemoglobin (HbF) inhibits sickle hemoglobin (HbS) polymerization, and it is well described that ...
Selami Demirci +3 more
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Neuroprotective effect of neuroglobin in hypoxia/ischemia
Сибирский научный медицинский журнал, 2021 Neuroglobin is a representative of the globin group, an oxygen-binding protein which is predominantly expressed in the nervous system. Despite the large amount of conducted research, its role is still poorly understood.
E. V. Uzlova, S. M. Zimatkin
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Modulating Nitric Oxide Dioxygenase and Nitrite Reductase of Cytoglobin through Point Mutations
Antioxidants, 2022 Cytoglobin is a hexacoordinate hemoglobin with physiological roles that are not clearly understood. Previously proposed physiological functions include nitric oxide regulation, oxygen sensing, or/and protection against oxidative stress under hypoxic ...
John Ukeri +2 more
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BMC Evolutionary Biology, 2020 Background How vascular systems and their respiratory pigments evolved is still debated. While many animals present a vascular system, hemoglobin exists as a blood pigment only in a few groups (vertebrates, annelids, a few arthropod and mollusk species).
Solène Song +6 more
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