Globin Associated Oxidative Stress [PDF]
Antioxidants, 2023 Globins have been studied for their “pseudo-peroxidase” activity for over 70 years, being an ideal model of other kinetically more rapid metalloenzymes [...]
Brandon J. Reeder
doaj +4 more sources
Neuroglobin and Cytoglobin in Mammalian Nervous Systems: About Distribution, Regulation, Function, and Some Open Questions [PDF]
Brain SciencesGlobins are a class of globular proteins that function in the transportation or storage of oxygen. They are critical for cellular metabolism. Notable examples include hemoglobin, which is found in red blood cells, and myoglobin, which is present in ...
Stefan Reuss
doaj +2 more sources
Engineering neuroglobin nitrite reductase activity based on myoglobin models [PDF]
Biochemistry and Biophysics Reports, 2023 Neuroglobin is a hemoprotein expressed in several nervous system cell lineages with yet unknown physiological functions. Neuroglobin presents a very similar structure to that of the related globins hemoglobin and myoglobin, but shows an hexacoordinate ...
Mark D. Williams +3 more
doaj +2 more sources
Redox Reactivity of Nonsymbiotic Phytoglobins towards Nitrite [PDF]
MoleculesNonsymbiotic phytoglobins (nsHbs) are a diverse superfamily of hemoproteins grouped into three different classes (1, 2, and 3) based on their sequences.
Cezara Zagrean-Tuza +4 more
doaj +2 more sources
Secretory Production of Plant Heme-Containing Globins by Recombinant Yeast via Precision Fermentation [PDF]
FoodsLeghemoglobin (LegHb) is a plant-derived heme-containing globin found in the root nodules of legumes like soybean that can be used as a food additive for red color and meaty flavor as a plant-based meat alternative.
Ha-Neul Bae +2 more
doaj +2 more sources
Nitric Oxide and Globin Glb1 Regulate Fusarium oxysporum Infection of Arabidopsis thaliana
Antioxidants, 2023 Plants continuously interact with fungi, some of which, such as Fusarium oxysporum, are lethal, leading to reduced crop yields. Recently, nitric oxide (NO) has been found to play a regulatory role in plant responses to F.
Laura C. Terrón-Camero +4 more
doaj +1 more source
A phylogenetic analysis of the globins in fungi. [PDF]
PLoS ONE, 2012 BackgroundAll globins belong to one of three families: the F (flavohemoglobin) and S (sensor) families that exhibit the canonical 3/3 α-helical fold, and the T (truncated 3/3 fold) globins characterized by a shortened 2/2 α-helical fold.
David Hoogewijs +4 more
doaj +1 more source
Ligand-Based Regulation of Dynamics and Reactivity of Hemoproteins
Biomolecules, 2023 Hemoproteins include several heme-binding proteins with distinct structure and function. The presence of the heme group confers specific reactivity and spectroscopic properties to hemoproteins.
Emily Samuela Turilli-Ghisolfi +2 more
doaj +1 more source
CRISPR-Cas9 to induce fetal hemoglobin for the treatment of sickle cell disease
Molecular Therapy: Methods & Clinical Development, 2021 Genome editing is potentially a curative technique available to all individuals with β-hemoglobinopathies, including sickle cell disease (SCD). Fetal hemoglobin (HbF) inhibits sickle hemoglobin (HbS) polymerization, and it is well described that ...
Selami Demirci +3 more
doaj +1 more source
Neuroprotective effect of neuroglobin in hypoxia/ischemia
Сибирский научный медицинский журнал, 2021 Neuroglobin is a representative of the globin group, an oxygen-binding protein which is predominantly expressed in the nervous system. Despite the large amount of conducted research, its role is still poorly understood.
E. V. Uzlova, S. M. Zimatkin
doaj +1 more source