Angewandte Chemie, Volume 137, Issue 21, May 19, 2025.Die Erzeugung funktionalisierter Ubiquitinbausteine mittels Expression in E. coli bietet Zugang zu verschiedenen Di‐, Tri‐ und Tetra‐Ubiquitinketten. Photoinitiierte Thiol‐En‐Klickreaktionen werden dabei in Kombination mit einer Maskierungs‐ und Schutzgruppenstrategie zum kontrollierten Aufbau von Ubiquitinketten sowie zur Semisynthese von ...
Moritz Urschbach +6 more
wiley +1 more source
The Virginia Sickle Cell Anemia Awareness Program: Education, Screening, and Counseling [PDF]
, 1977 In 1968, a program of screening for sickle trait carriers was begun as part of the work of the Hematology Division, Department of Medicine, at the Medical College of Virginia.
Cooper, Florence N., Scott, Robert B.
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Angewandte Chemie International Edition, Volume 64, Issue 21, May 19, 2025.Generating functionalized ubiquitin building blocks via expression in E. coli paves the way to different di‐, tri‐, and tetra‐ubiquitin chains. Light‐induced thiol‐ene click reactions, combined with a masking and protection strategy, are harnessed to establish controlled ubiquitin chain assembly and to allow the semisynthesis of site‐selectively ...
Moritz Urschbach +6 more
wiley +1 more source
cGAS/STING‐Independent Induction of Type I Interferon by Inhibitors of the Histone Methylase KDM5B
The FASEB Journal, Volume 39, Issue 9, 15 May 2025.Mechanism of HEXIM1 regulation of Type I Interferon. ABSTRACT Studies support the role of hexamethylene bis‐acetamide [HMBA] induced protein 1 (HEXIM1) as a tumor suppressor. We previously reported that the histone demethylase, KDM5B, inhibits the expression of HEXIM1, and KDM5B inhibitors (KDM5Bi) upregulate HEXIM1 expression. As a consequence, KDM5Bi
Monica M. Montano +2 more
wiley +1 more source
HSCB, a co-chaperone in mitochondrial iron-sulfur cluster biogenesis, is a novel candidate gene for congenital sideroblastic anemia [PDF]
, 2017 Congenital sideroblastic anemias (CSA) are inherited diseases resulting from defects in heme biosynthesis, mitochondrial iron-sulfur cluster (ISC) assembly, or mitochondrial translation.
Crispin, Andrew
core
Intrinsic non-symbiotic and truncated haemoglobins and heterologous Vitreoscilla haemoglobin expression in plants [PDF]
, 2017 To date, haemoglobins (Hbs) have been shown to exist in all kingdoms of life. The least studied and understood groups are plant non-symbiotic haemoglobins (nsHbs) and the recently found plant truncated Hbs (trHbs).
Frey, Alexander D. +3 more
core
Local energetic frustration conservation in protein families and superfamilies. [PDF]
Nat Commun, 2023 Freiberger MI +11 more
europepmc +1 more source
Insights into the function of cytoglobin. [PDF]
Biochem Soc Trans, 2023 Reeder BJ.
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Diversity and conservation of interactions for binding heme in b-type heme proteins [PDF]
, 2007 Marles-Wright, Jon +3 more
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Engineering neuroglobin nitrite reductase activity based on myoglobin models. [PDF]
Biochem Biophys Rep, 2023 Williams MD +3 more
europepmc +1 more source