Results 111 to 120 of about 17,498 (250)

Muscle oxygen saturation plateau: Definition and verification in different oxygen availability conditions in locomotor and non‐locomotor muscles

Experimental Physiology, Volume 111, Issue 2, Page 464-473, 1 February 2026.
Abstract Novel wearable near‐infrared spectroscopy devices allow for a better understanding of muscle oxygenation kinetics during exercise. A muscle oxygen saturation (SmO2) plateau is often applied in the scientific literature, but clear criteria for its definition remain unestablished to date.
Tomasz Kowalski, Kinga Rębiś, Adrian Wilk, Dominika Granda, Andrzej Białecki, Tadej Debevec, Raphael Faiss   +6 more
wiley   +1 more source

Unstable Hemoglobin, a Rare but Significant Cause of Hemolytic Anemia: Recognition of Peripheral Smear Findings Is Crucial for Diagnosis

International Journal of Laboratory Hematology, EarlyView.
Ryan C. Shean, Archana Agarwal, Anton V. Rets   +2 more
wiley   +1 more source

Enhancer‐dependent gene regulation in space, time, and malignancies

International Journal of Cancer, Volume 158, Issue 2, Page 357-367, 15 January 2026.
Abstract Control of cell‐type‐specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells.
Belinda Blum, Victoria Dachtler, Angelika Feldmann   +2 more
wiley   +1 more source

Two mutations in the beta-globin polyadenylylation signal reveal extended transcripts and new RNA polyadenylylation sites.

, 1992
Deborah Rund, Carol E. Dowling, Khamis Najjar, E. A. Rachmilewitz, H H Kazazian, A Oppenheim   +5 more
openalex   +2 more sources

Unveiling the Genetic Association Between Hemoglobin Concentration and Amyotrophic Lateral Sclerosis

Brain and Behavior, Volume 16, Issue 1, January 2026.
This study identified a causal relationship between genetically predicted hemoglobin (Hb) concentration and amyotrophic lateral sclerosis (ALS) through Mendelian randomization (MR), and integrated RNA‐seq and RT‐qPCR analyses to highlight BACH1, FLVCR1, and TRIM58 as potential genes involved in this association.
Hongmei Luo, Yujie Yang, Xiaojian Cao, Chunchu Deng, Hong Chen   +4 more
wiley   +1 more source

A new hereditary persistence of fetal hemoglobin deletion has the breakpoint within the 3' beta-globin gene enhancer [PDF]

, 1990
Clara Camaschella, Angelo Serra, E Gottardi, A Alfarano, D. Revello, U Mazza, Giuseppe Saglio   +6 more
openalex   +1 more source

Human Protein Z as the Second Known Heme‐Binding Protein from the Endogenous Blood Coagulation Inhibitor System

ChemBioChem, Volume 27, Issue 1, January 2026.
Protein Z is a vitamin K‐dependent anticoagulant with elusive molecular functions. Herein, it is shown that heme binds to protein Z and induces conformational changes. One histidine‐based heme‐binding motif is identified. High heme‐binding affinity and functional effects are demonstrated on protein level. These findings shed new light on the structural
Paula Lindemann, Marie‐T. Hopp
wiley   +1 more source

Detection of Rare Thalassemia Variants Using Accurate Circular Consensus Long-Read Sequencing. [PDF]

Hum Mutat
Objective The aim of this study is to evaluate the efficacy of accurate circular consensus long‐read sequencing in the detection of rare thalassemia. Methods Conventional molecular analysis on globin genes has limitations because of the broad spectrum of genetic variants, complex genetics, and genotype–phenotype correlation. Accurate circular consensus
Zhou X, Chen Y, Chen S, Lian J, Liu Y, Yang T, Wu S, Liu J, Huang X, Yang X.   +9 more
europepmc   +2 more sources

A Stable Bioisostere of Ester‐Linked Ubiquitin Chains Enables Decoding of Protein Interactors

ChemBioChem, Volume 27, Issue 1, January 2026.
An ester‐to‐amide analog of an ester‐linked ubiquitin dimer is chemically synthesized through a convergent approach involving the sequential chemoselective ligation of three peptide fragments generated through Fmoc‐based solid‐phase peptide synthesis. The hydrolysis‐resistant ubiquitin dimer served as a chemical probe in the identification of potential
Yoshinori Taguchi, Takuya Tomita, Takuma Nishizawa, Dai Nakamura, Showmitra Saha, Takanori Oyoshi, Kohei Sato, Nobuyuki Mase, Yasushi Saeki, Tetsuo Narumi   +9 more
wiley   +1 more source

Assessment of high resolution melt analysis feasibility for evaluation of beta-globin gene mutations as a reproducible, cost-efficient and fast alternative to the present conventional method

, 2016
Mahboubeh Ramezanzadeh, Mansour Salehi, Rasoul Salehi   +2 more
openalex   +1 more source