Advanced Science, Volume 13, Issue 21, 13 April 2026.This study presents a machine‐learning framework entitled MERLIN that infers the microanatomical localization of macrophages from single‐cell transcriptomic data in structured organs such as the kidney and brain. Applying this method to existing datasets from models of acute kidney injury and diabetic nephropathy uncovered spatially resolved insights ...
Junping Yin +18 more
wiley +1 more source
Calcium Shock Enables Efficient and Programmable Particle Delivery for Genome Editing Applications
Advanced Science, Volume 13, Issue 21, 13 April 2026.Classical transfection and transduction are inefficient, particularly with confluent cells and organoids, and lack cell type‐specific programmability. This study presents calcium shock (CaSh), a method that dramatically improves particle delivery into single cells, colonies, and organoids.
Nicole Vo +12 more
wiley +1 more source
Integrative Approaches to Treating Cellular Senescence in Kidney Disease
Advanced Science, Volume 13, Issue 21, 13 April 2026.ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa +3 more
wiley +1 more source
Collapsing glomerulopathy: A 30-year perspective and single, large center experience [PDF]
, 2017 Cossey, Nicholas +2 more
core +2 more sources
Deletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGFβ1 signaling pathway [PDF]
, 2017 TRPC6 plays a critical role in proteinuric kidney diseases, and TRPC3 is involved in tubulointerstitialdamage and renal fibrosis in obstructed kidneys. Podocyte loss is a characteristic event in diabetic nephropathy(DN).
Birnbaumer, Lutz +5 more
core
A Case Study and Review of the Literature on IgA Nephropathy in Crohn's Disease
Clinical Case Reports, Volume 14, Issue 4, April 2026.ABSTRACT IgA nephropathy (IgAN) is the most frequently reported glomerular disease associated with inflammatory bowel disease (IBD), particularly Crohn's disease (CD), although pediatric cases remain rare. We report IgAN in a 16‐year‐old male with CD following intestinal surgery and during long‐term infliximab therapy, with renal impairment occurring ...
Giovanna Fernanda Vazzana +6 more
wiley +1 more source
World small animal veterinary association renal pathology initiative: classification of glomerular diseases in dogs [PDF]
, 2015 Aresu, L +16 more
core +2 more sources
Leveraging extracellular vesicle biology for novel tests and therapeutics for kidney fibrosis
Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.Extracellular vesicles (EVs) are bilipid membrane‐encased nanoparticles that play critical roles as cell‐to‐cell messengers and waste management mechanisms. EVs cargos can be leveraged as biomarkers to develop minimally invasive tests for kidney fibrosis and guide personalised mechanism‐driven care.
Chin‐Ya Sophie Chiang +3 more
wiley +1 more source
Inflammatory Response as a Mechanism of Perinatal Programming: Long-term Impact on Pulmonary and Renal Function? [PDF]
, 2012 RATIONALE: Temporal changes in the fetal environment, such as malnutrition and placental insufficiency induce intrauterine growth restriction (IUGR) and lead to a permanent changes of physiological processes later in life.
Alejandre Alcázar, Miguel Angel
core
Immunity, Inflammation and Disease, Volume 14, Issue 4, April 2026.Expression of molecules related to the activation of NLRP3 inflammasomes and NIAHGs. (A) Immunoblot analysis of NLRP3, pro‐caspase‐1, caspase‐1 p20, and NIAHGs proteins in renal tissues from NC, eDN, and aDN patients. (B–E) Relative IL‐1β and IL‐18 levels across groups determined by RT‐qPCR (B, C) and ELISA (D, E).
Sheng Zhao +8 more
wiley +1 more source