Results 71 to 80 of about 56,062 (233)

Intravital imaging of adriamycin-induced renal pathology using two-photon microscopy and optical coherence tomography [PDF]

Journal of Innovative Optical Health Sciences, 2018
Adriamycin (doxorubicin), a common cancer chemotherapeutic drug, can be used to induce a model of chronic progressive glomerular disease in rodents. In our studies, we evaluated renal changes in a rat model after Adriamycin injection using two-photon ...
Hengchang Guo, Hsing-Wen Wang, Qinggong Tang, Erik Anderson, Reuben Falola, Tikina Smith, Yi Liu, Moshe Levi, Peter M. Andrews, Yu Chen   +9 more
doaj   +1 more source

Scopoletin and umbelliferone from Cortex Mori as protective agents in high glucose-induced mesangial cell as in vitro model of diabetic glomerulosclerosis

Chinese Journal of Physiology, 2021
Two known coumarins, scopoletin (SP) and umbelliferone (UB), were isolated from Cortex Mori (CM). Their structures were elucidated by various spectroscopic analyses.
Yijun Liang, Xuxin Zeng, Jialiang Guo, Hui Liu, Bao He, Renyu Lai, Quan Zhu, Zhaoguang Zheng   +7 more
doaj   +1 more source

Idiopathic nodular glomerulosclerosis in a chronic marijuana user; a case report and review of the literature [PDF]

, 2017
Background: Nodular glomerulosclerosis is a characteristic histological finding of diabetic nephropathy (DN) with thickened glomerular basement membrane (GBM) and hyalinized arterioles.
Abdul Salim, Sohil, Fülöp, Tibor, Hamrahian, Seyed Mehrdad, Mollaee, Mehri   +3 more
core   +2 more sources

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, EarlyView.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Therapeutic potential of stromal vascular fraction in early diabetic nephrotoxicity: a histomorphometric and immunohistochemical analysis in a type 2 diabetes rat model

Folia Morphologica
BACKGROUND: Diabetic nephropathy (DN), a common complication of type 2 diabetes (T2D), significantly contributes to end-stage kidney disease (ESKD). Despite conventional treatments aimed at slowing disease progression, there is a pressing need for novel ...
Amany Elsayed Hamoud, Hanaa Wanas, Ahmed Hamed Bayoumi, Doaa Mahmoud Shuaib, Maha Baligh Zickri, Mai Abdel Aziz Gouda, Ahmed Galal Motawie   +6 more
doaj   +1 more source

An Integrative in silico Study to Discover Key Drivers in Pathogenicity of Focal and Segmental Glomerulosclerosis

Kidney & Blood Pressure Research, 2022
Background: Focal and segmental glomerulosclerosis (FSGS) is a clinical-pathologic condition marked by segmental and localized glomerular damages. Despite investigations, the molecular mechanisms behind FSGS development remain to be more clarified.
Alieh Gholaminejad, Maryam Ghaeidamini, Jesus Simal-Gandara, Amir Roointan   +3 more
doaj   +1 more source

Current Status of Kidney Xenotransplantation in Basic Research

Organ Medicine, EarlyView.
Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley   +1 more source

Loss of phosphatidylserine flippase β-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis

Disease Models & Mechanisms, 2021
The asymmetric distribution of phosphatidylserine (PS) in the cytoplasmic leaflet of eukaryotic cell plasma membranes is regulated by a group of P4-ATPases (named PS flippases) and the β-subunit TMEM30A.
Wenjing Liu, Lei Peng, Wanli Tian, Yi Li, Ping Zhang, Kuanxiang Sun, Yeming Yang, Xiao Li, Guisen Li, Xianjun Zhu   +9 more
doaj   +1 more source

Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids and its modification by Stearoyl-CoA desaturases and cyclic AMP [PDF]

, 2011
Podocyte apoptosis is a hallmark in the development and progression of diabetic nephropathy (DN). Several factors of the diabetic milieu are known to induce podocyte apoptosis. Currently, the role of free fatty acids (FFAs) for podocytopathy and podocyte
Sieber, Jonas
core   +1 more source

Keap1 inhibition attenuates glomerulosclerosis [PDF]

Nephrology Dialysis Transplantation, 2014
NFE2-related factor 2 (Nrf2) is a master regulatory transcription factor for antioxidant genes. Inhibition of its adaptor protein, Kelch-like ECH-associated protein 1 (Keap1), activates Nrf2. Podocyte injury triggers the progressive deterioration of glomerular damage toward glomerulosclerosis. We examined whether modulation of the Keap1-Nrf2 system has
Yoichi, Miyazaki, Akihiro, Shimizu, Ira, Pastan, Keiko, Taguchi, Eriko, Naganuma, Takafumi, Suzuki, Tatsuo, Hosoya, Takashi, Yokoo, Akihiko, Saito, Toshio, Miyata, Masayuki, Yamamoto, Taiji, Matsusaka   +11 more
openaire   +2 more sources