Results 61 to 70 of about 56,062 (233)

"Suboptimal" kidney donors: The experience with tacrolimus-based immunosuppression [PDF]

, 1996
Female, pediatric, and older donors have been associated with inferior graft survival after renal transplantation. We analyzed these three subgroups in 397 patients receiving tacrolimus-based immunosuppression. There were no differences in recipient age,
Alexander, Brenner, Brenner, Darras, Demetris, Gjertson, Gruessner, Hong, Laskow, McCauley, Neugarten, Nghiem, Opelz, Ploeg, Randhawa, Shapiro, Shapiro, Shapiro, Shapiro, Smith, Starzl, Starzl, Thorogood, Vivas   +23 more
core   +1 more source

5‐Methylcytosine Analysis of miRNAs in Minimal Change Disease

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Minimal change disease (MCD) is a glomerular disorder, which is the most common cause of nephrotic syndrome in children. Additionally, the prevalence of MCD in adults has been increasing in recent years. During protein synthesis, noncoding RNAs can be regulated through a variety of modifications, which helps preserve biological diversity and ...
Huiyi Zeng, Dandan Li, Yunyi Li, Chen Yun, Xinzhou Zhang, Wenyu Gong, Mengyun Xiao, Haitao Li, Zhipeng Zeng, Ruqi Tan, Yishen Yang, Shaodong Luan, Yong Dai, Lianghong Yin, Donge Tang   +14 more
wiley   +1 more source

Only IF/TA in the Histological Evaluation of Post-Reperfusion Baseline Biopsies Correlates With Kidney Transplant Outcome

Transplant International
Here, we retrospectively evaluated the informational yield of 338 post-reperfusion kidney transplant biopsies (including 95 living donations) assessed according to BANFF for the histological characteristics interstitial fibrosis and tubular atrophy (IF ...
Quirin Bachmann, Carlos Torrez, Maike Büttner-Herold, Bernhard Haller, Flora Haberfellner, Renate Hausinger, Volker Assfalg, Lutz Renders, Kerstin Amann, Uwe Heemann, Christoph Schmaderer, Stephan Kemmner, Stephan Kemmner   +12 more
doaj   +1 more source

PATHOMORPHOLOGY OF ZERO BIOPSIES OF DONOR KIDNEYS

Вестник трансплантологии и искусственных органов, 2011
There is well known fact that kidney transplants from Extended Criteria Donors may increase risk of De- layed Graft Function and Primary Non-Function of transplants.
M. L. Arefjev, M. G. Minina, N. P. Mogeiko, I. M. Iljinsky   +3 more
doaj   +1 more source

Effects of TRPC6 Inactivation on Glomerulosclerosis and Renal Fibrosis in Aging Rats

Cells, 2021
Canonical transient receptor potential 6 (TRPC6) channels have been implicated in familial and acquired forms of focal and segmental glomerulosclerosis (FSGS) in patients and animal models, as well as in renal fibrosis following ureteral obstruction in ...
Eun Young Kim, Stuart E. Dryer
doaj   +1 more source

Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-ß antibody in \u3ci\u3edb/db\u3c/i\u3e diabetic mice [PDF]

, 2000
Emerging evidence suggests that transforming growth factor-(TGF-β) is an important mediator of diabetic nephropathy. We showed previously that short-term treatment with a neutralizing monoclonal anti-TGF-antibody (αT) in streptozotocin-diabetic mice ...
Chen, Sheldon, Han, Dong Cheol, Hoffman, Brenda B., Hong, Soon Won, Iglesias-de la Cruz, M. Carmen, Isono, Motohide, McGowan, Tracy A., Sharma, Kumar, Ziyadeh, Fuad N.   +8 more
core   +1 more source

Lipoatrophic diabetes. Report of a case [PDF]

, 1978
The female patient initially showed the acquired type of total lipoatrophy at about 8 years of age. At 12 years of age, the onset of diabetes mellitus was speculated from advanced pyodermia and dedentition.
Aoi, Katsuyuki, Kawanishi, Koichi, Nishina, Yoshiaki, Ofuji, Tadashi, Saito, Yoshihito, Sarai, Tetsuo   +5 more
core   +1 more source

Construction of Chronic Kidney Disease Mouse Model Induced by Diets With Different Adenine Content

Food Safety and Health, EarlyView.
By administering a 4 weeks adenine diet to C57BL/6J mice, we identified 0.2% adenine in purified feed as the optimal chronic kidney disease model. This model induces severe renal damage, gut dysbiosis, uremic toxin accumulation, and CKD mineral bone disorder, providing a clinically relevant platform for mechanistic and therapeutic studies.
Wanjun Liao, Jiayao Wang, Yilian Huang, Na Zhang, Xiaodan Shi, Zongcai Tu, Zuohua Xie, Tao Yuan, Hongmei Yin   +8 more
wiley   +1 more source

Adenosine A_2B Receptor Antagonism Interferes with TGF-β Cellular Signaling Through SMAD2/-3 and p65-Nf-κB in Podocytes and Protects from Phenotypical Transformation in Experimental Diabetic Glomerulopathy

Cells
Studies have emphasized alleviating fibrogenesis through interference with adenosine signaling in experimental diabetic nephropathy. We found that the in vivo antagonism of the adenosine A2B receptor (A2BAR) using MRS1754 in diabetic rats impedes the ...
Ignacio Arias, Claudia Jara, Pablo Mendoza-Soto, Yessica Nahuelpán, Claudio Cappelli, Carlos Oyarzún, Diego Carrillo-Beltrán, Claudia Quezada-Monrás, Angelo Torres-Arévalo, Rody San Martín   +9 more
doaj   +1 more source

Development of the Diabetic Kidney Disease Mouse Model Culturing Embryos in α-Minimum Essential Medium In Vitro, and Feeding Barley Diet Attenuated the Pathology

Frontiers in Endocrinology, 2021
Diabetic kidney disease (DKD) is a critical complication associated with diabetes; however, there are only a few animal models that can be used to explore its pathogenesis. In the present study, we established a mouse model of DKD using a technique based
Shiori Ishiyama, Mayu Kimura, Takao Nakagawa, Yuka Fujimoto, Kohei Uchimura, Satoshi Kishigami, Satoshi Kishigami, Kazuki Mochizuki, Kazuki Mochizuki   +8 more
doaj   +1 more source