Results 41 to 50 of about 45,138 (251)

Oxford-MEST classification in IgA nephropathy patients: A report from Iran [PDF]

Journal of Nephropathology, 2012
Background: There is a limited knowledge about the morphological features of IgA nephropathy (IgAN)in the middle east region. Objectives: The objective of this study was to evaluate the spectrum of histopathological findings in IgAN patients at our ...
Hamid Nasri, Mojgan Mortazavi, Ali Ghorbani, Heshmatollah Shahbazian, Soleiman Kheiri, Azar Baradaran, Afsoon Emami-Naieni, Maryam Saffari, Saeed Mardani, Ali Momeni, Yahya Madihi, Milad Baradaran-Ghahfarokhi, Mahmoud Rafieian-Kopaie, Parin Hedayati, Shahzad Baradaran, Mohammadreza Ardalan, Shahram Sajjadieh, Naziheh Assarzadegan, Seyed Mohammad Ahmadi Soleimani, Mohamad Reza Tamadon   +19 more
doaj   +1 more source

Renal Tubular Epithelial CRLF1 Interacts With ITGB1 to Accelerate Fibrosis During the Transition From AKI to CKD

Advanced Science, EarlyView.
During renal fibrosis, SMAD3 acts as a transcription factor for CRLF1, promoting its expression and secretion. CRLF1 then binds to ITGB1 via an autocrine mechanism, activating the PI3K‐AKT signaling pathway to mediate renal fibrosis. This accelerates the progression from AKI to CKD, highlighting the therapeutic potential of targeting CRLF1 for ...
Chunjie Wang, Yan Zhang, Fang Bai, Shankui Qian, Feng Feng, Fangyi Lu, Jiahui Fan, Kuipeng Yu, Xiangdong Yang   +8 more
wiley   +1 more source

Association of Ancillary Pathology Findings in Non-neoplastic Renal Parenchyma and Renal Outcomes of Robotic-Assisted Partial Nephrectomy

Frontiers in Surgery, 2021
Background: To evaluate robotic-assisted partial nephrectomy (RAPN) renal outcomes associated with ancillary pathology findings in non-neoplastic renal parenchymal tissue.Methods: Tissue samples from 378 RAPNs were analyzed for glomerular disease (GD ...
Laura E. Geldmaker, Amanda E. Kahn, Kevin A. Parikh, Ivan E. Porter, Daniela A. Haehn, Essa M. Bajalia, Qihui Zhai, Colleen T. Ball, David D. Thiel   +8 more
doaj   +1 more source

T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease

Advanced Science, EarlyView.
This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li, Junting Guan, Yifan Song, Hongxia Yang, Guangtao Li, Xiaodong Zhao, Jiaxin Liu, Bin Liu, Yang Tan, Honglan Zhou, Yang‐He Zhang, Yishu Wang   +11 more
wiley   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Podocyte injury in diabetes mellitus

Сахарный диабет, 2014
The mechanisms of podocyte injury and their correlation with metabolic and haemodynamic disorders in diabetes mellitus are considered in detail; the results of the last experimental and clinical studies on this problem are presented in this review ...
Irina Nikolaevna Bobkova, Marina Vladimirovna Shestakova, Anna Alexandrovna Shchukina   +2 more
doaj   +1 more source

Anti-Inflammatory, Antioxidant, and Antifibrotic Effects of Kefir Peptides on Salt-Induced Renal Vascular Damage and Dysfunction in Aged Stroke-Prone Spontaneously Hypertensive Rats

Antioxidants, 2020
The increased prevalence of renal dysfunction and chronic kidney disease (CKD) and the high costs and poor outcomes of treatment are a significant health issue.
Yu-Hsuan Chen, Hsiao-Ling Chen, Hueng-Chuen Fan, Yu-Tang Tung, Chia-Wen Kuo, Min-Yu Tu, Chuan-Mu Chen   +6 more
doaj   +1 more source

Prognostic value of chronicity grading on renal outcomes in patients with IgA nephropathy

Frontiers in Medicine, 2022
Many studies have shown that chronic changes are strong predictors of renal outcomes in various kidney diseases, including IgA nephropathy. The Mayo Clinic/Renal Pathology Society suggested a glomerulonephritis reporting system with a proposal for ...
Donghyuk Kang, Tae Hyun Ban, Ho Jun Chin, Hajeong Lee, Se Won Oh, Cheol Whee Park, Chul Woo Yang, Bum Soon Choi   +7 more
doaj   +1 more source

Baseline podocyte‐associated state and persistent cell–matrix transcriptional programs are associated with BALB/c substrain differences in adriamycin nephropathy

Animal Models and Experimental Medicine, EarlyView.
Two closely related BALB/c substrains exhibit different early responses to adriamycin (ADR)‐induced nephropathy. BALB/cByJcl mice showed lower baseline WT1‐positive nuclei counts and NPHS1 immunoreactivity than BALB/cAJcl mice, together with extracellular matrix and integrin programs that were enriched at baseline and persisted at Day 5.
Ryuya Nakagawa, Masaki Watanabe, Koyuki Kawamoto, Momoka Hiratsuka, Takeru Sasaki, Nobuya Sasaki   +5 more
wiley   +1 more source

Glomerulosclerosis.

, 2016
Representative glomerular images (A-D) and with quantitative analysis (E) of periodic acid-Schiff stained kidney sections. When compared with animals that had undergone sham surgery (A, B), kidney sections from SNX rats (C, D) show substantial ...
David M. Kepecs (844222), Kerri Thai (252495), Yanling Zhang (6561), Richard E. Gilbert (204424)   +3 more
core   +1 more source