Results 51 to 60 of about 45,138 (251)

Detection of Glomerulosclerosis in Diabetic Nephropathy Using Contour-based Segmentation [PDF]

, 2015
We have proposed a method for detection of glomerulosclerosis in diabetic nephropathy using Contour-Based Segmentation. Pathological images of the glomerulosclerosis were acquired from various patients.
Ravi, M., Hegadi, Ravindra S.
core   +1 more source

The womb as the cradle of longevity: Perinatal origins of biological aging

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract The perinatal period is increasingly recognized as an important determinant of biological aging trajectories and disease susceptibility across the lifespan. This narrative review synthesizes current evidence linking intrauterine exposures to adult health outcomes across three biological dimensions: fetal programming, maternal influences, and ...
Sevim Ozge Ozdemir, Ebru Davutoglu
wiley   +1 more source

Primary Focal Segmental Glomerulosclerosis: Why Are Pieces of This Puzzle Still Missing? [PDF]

, 2015
Focal segmental glomerulosclerosis (FSGS) can be classified as primary or secondary. Moreover, many causes of primary FSGS have been identified in recent years. In this regard, genetic circulating permeability factors and the abnormal podocyte expression
Hernán Trimarchi
core  

Effects of TRPC6 Inactivation on Glomerulosclerosis and Renal Fibrosis in Aging Rats

Cells, 2021
Canonical transient receptor potential 6 (TRPC6) channels have been implicated in familial and acquired forms of focal and segmental glomerulosclerosis (FSGS) in patients and animal models, as well as in renal fibrosis following ureteral obstruction in ...
Eun Young Kim, Stuart E. Dryer
doaj   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Development of the Diabetic Kidney Disease Mouse Model Culturing Embryos in α-Minimum Essential Medium In Vitro, and Feeding Barley Diet Attenuated the Pathology

Frontiers in Endocrinology, 2021
Diabetic kidney disease (DKD) is a critical complication associated with diabetes; however, there are only a few animal models that can be used to explore its pathogenesis. In the present study, we established a mouse model of DKD using a technique based
Shiori Ishiyama, Mayu Kimura, Takao Nakagawa, Yuka Fujimoto, Kohei Uchimura, Satoshi Kishigami, Satoshi Kishigami, Kazuki Mochizuki, Kazuki Mochizuki   +8 more
doaj   +1 more source

Secondary Focal Segmental Glomerulosclerosis: From Podocyte Injury to Glomerulosclerosis [PDF]

BioMed Research International, 2016
Focal segmental glomerulosclerosis (FSGS) is a common cause of proteinuria and nephrotic syndrome leading to end stage renal disease (ESRD). There are two types of FSGS, primary (idiopathic) and secondary forms. Secondary FSGS shows less severe clinical features compared to those of the primary one.
Kim, Jae Seok, Han, Byoung Geun, Choi, Seung Ok, Cha, Seung-Kuy   +3 more
openaire   +2 more sources

GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction, including mitochondrial biogenesis, mitophagy, dynamics and oxidative stress, occurs in the early stages of diabetic tubulopathy, which precede proteinuria and renal histological changes. GSK3β is a potential novel biomarker for the prediction of diabetic tubulopathy.
Lan Yao, Xianhui Liang, Bingyu Li, Bohan Chen, Xiaoyang Wang, Mei Hong, Qi Feng, Yingjin Qiao, Zhangsuo Liu, Kai Wang, Pei Wang   +10 more
wiley   +1 more source

Intravital imaging of adriamycin-induced renal pathology using two-photon microscopy and optical coherence tomography [PDF]

Journal of Innovative Optical Health Sciences, 2018
Adriamycin (doxorubicin), a common cancer chemotherapeutic drug, can be used to induce a model of chronic progressive glomerular disease in rodents. In our studies, we evaluated renal changes in a rat model after Adriamycin injection using two-photon ...
Hengchang Guo, Hsing-Wen Wang, Qinggong Tang, Erik Anderson, Reuben Falola, Tikina Smith, Yi Liu, Moshe Levi, Peter M. Andrews, Yu Chen   +9 more
doaj   +1 more source

Scopoletin and umbelliferone from Cortex Mori as protective agents in high glucose-induced mesangial cell as in vitro model of diabetic glomerulosclerosis

Chinese Journal of Physiology, 2021
Two known coumarins, scopoletin (SP) and umbelliferone (UB), were isolated from Cortex Mori (CM). Their structures were elucidated by various spectroscopic analyses.
Yijun Liang, Xuxin Zeng, Jialiang Guo, Hui Liu, Bao He, Renyu Lai, Quan Zhu, Zhaoguang Zheng   +7 more
doaj   +1 more source