Results 31 to 40 of about 45,138 (251)

Specific renal parenchymal-derived urinary extracellular vesicles identify age-associated structural changes in living donor kidneys [PDF]

Journal of Extracellular Vesicles, 2016
Non-invasive tests to identify age and early disease-associated pathology within the kidney are needed. Specific populations of urinary extracellular vesicles (EVs) could potentially be used for such a diagnostic test.
Anne E. Turco, Wing Lam, Andrew D. Rule, Aleksandar Denic, John C. Lieske, Virginia M. Miller, Joseph J. Larson, Walter K. Kremers, Muthuvel Jayachandran   +8 more
doaj   +1 more source

Kidney aging.Geriatric view

Российский журнал гериатрической медицины, 2021
Individuals age >65 years old are the fastest expanding population demographic throughout the developed world. Consequently, more aged patients than before are receiving diagnoses of impaired renal function and nephrosclerosis.
L. I. Merkusheva, N. K. Runikhina, O. N. Tkacheva   +2 more
doaj   +1 more source

Glomerulosclerosis in STNx rats.

, 2015
As illustrated by representative photomicrographs, in sham rats (A) there was minimal glomerulosclerosis as determined by PAS stain, while STNx rats (B) demonstrated severe glomerulosclerosis.
Elizabeth K. M. Johnstone (711520), Kevin D. G. Pfleger (176476), James H. Williams (489711), Mohammed Akli Ayoub (176430), Robyn S. Kelly (711519), Darren J. Kelly (252497), Heng B. See (587137), Elizabeth A. McCall (711521), Yuan Zhang (41832)   +8 more
core   +1 more source

IgA Nephropathy Associated with IgA Vasculitis Coexisting with Focal Segmental Glomerulosclerosis Tip Variant

Journal of Renal and Hepatic Disorders, 2023
IgA vasculitis (IgAV), previously known as Henoch–Schönlein purpura, is a form of small vessel vasculitis that affects the skin, joints, intestines, and kidneys.
Zitlali Guadalupe Paulín Zepeda, Karla Daniela Salgado Guizar, Vianey Guadalupe Tellez Bolaños, Louis Fernando Robles Fernandes, María Inés Gil Arredondo   +4 more
doaj   +1 more source

Establishing equivalent diabetes in male and female Nos3‐deficient mice results in a comparable onset of diabetic kidney injury

Physiological Reports, 2019
Clinical studies indicate that sex differences exist in susceptibility for developing diabetic kidney disease (DKD), supporting the need to examine both sexes in animal studies of DKD. Streptozotocin (STZ) is commonly used in male mice to induce diabetes
Lifang Tian, David J. Nikolic‐Paterson, Greg H. Tesch   +2 more
doaj   +1 more source

Role of Protein Kinase C (PKC) in Podocytes and Development of Glomerular Damage in Diabetic Nephropathy

Frontiers in Endocrinology, 2014
The early glomerular changes in diabetes include a podocyte phenotype with loss of slit diaphragm proteins, changes in the actin cytoskeleton and foot process architecture.
Beina eTeng, Michelle eDuong, Irini eTossidou, Xuejiiao eYu, Mario eSchiffer   +4 more
doaj   +1 more source

Protective effects of oleuropein against renal injury oxidative damage in alloxan-induced diabetic rats; a histological and biochemical study [PDF]

Journal of Nephropathology, 2017
Background: Oleuropein is a potent antioxidant and free-radical scavenger with antiinflammatory properties. Objectives: In the present study, we evaluated the protective effects of oleuropein on myeloperoxidase (MPO) activity, nitrite, urea, creatinine ...
Hassan Ahmadvand, Gholamreza Shahsavari, Majid Tavafi, Shahrokh Bagheri, Mohamad Reza Moradkhani, Reza Mohammadrezaei Kkorramabadi, Peyman Khosravi, Maryam Jafari, Khadije Zahabi, Reza Eftekhar, Maryam Soleimaninejad, Sanaz Moghadam   +11 more
doaj   +1 more source

Early Renoprotective Effect of Ruxolitinib in a Rat Model of Diabetic Nephropathy

Pharmaceuticals, 2021
Diabetic kidney disease (DKD) is still one of the unresolved major complications of diabetes mellitus, which leads ultimately to end-stage renal disease in both type 1 and type 2 diabetes patients.
Mohamed M. El-Kady, Reham A. Naggar, Maha Guimei, Iman M. Talaat, Olfat G. Shaker, Maha Saber-Ayad   +5 more
doaj   +1 more source

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

Advanced Science, EarlyView.
The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng, Qinghuan Shen, Junqi Zhang, Jiawen Liu, Zeping Gui, Zijie Wang, Qianguang Han, Shuang Fei, Hao Chen, Li Sun, Jun Tao, Zhijian Han, Xiaobing Ju, Min Gu, Jianjian Zhang, Ruoyun Tan   +15 more
wiley   +1 more source

Glomerulus Classification via an Improved GoogLeNet

IEEE Access, 2020
Glomerulosclerosis is a pathomorphological feature of glomerular lesions. Early detection, accurate judgement and effective prevention of the glomeruli is crucial not only for people with kidney disease, but also for the general population. We proposed a
Xujing Yao, Xinyue Wang, Yeliz Karaca, Jiayong Xie, Shuihua Wang   +4 more
doaj   +1 more source