Results 11 to 20 of about 56,062 (233)
Frontiers in Physiology, 2020 High glucose concentration can activate TLR4 and NF-κB, triggering the production of proinflammatory mediators. We investigated whether the NF-κB pathway is involved in the pathogenesis and progression of experimental diabetic kidney disease (DKD) in a ...
Orestes Foresto-Neto +11 more
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Complement, a Therapeutic Target in Diabetic Kidney Disease
Frontiers in Medicine, 2021 Currently available treatments of diabetic kidney disease (DKD) remain limited despite improved understanding of DKD pathophysiology. The complement system is a central part of innate immunity, but its dysregulated activation is detrimental and results ...
Kelly Budge +3 more
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Adult-Onset Genetic Focal Segmental Glomerulosclerosis: A Tale of Two Mutations
Revista Portuguesa de Nefrologia e Hipertensão, 2023 Focal segmental glomerulosclerosis (FSGS) is a kidney histologic lesion that may be caused by multiple aetiologies and pathophysiological mechanisms, with podocyte injury and depletion as the common denominator.
Luís Leite de Sousa +4 more
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Cells, 2020 Diabetic nephropathy (DN) is considered the main cause of kidney disease in which myofibroblasts lead to renal fibrosis. Macrophages were recently identified as the major source of myofibroblasts in a process known as macrophage–myofibroblast transition (
Ángelo Torres +10 more
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miR-135a-5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure. [PDF]
Adv Sci (Weinh)Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Zhao X +8 more
europepmc +2 more sources
Cytokines and glomerulosclerosis [PDF]
Nephrology Dialysis Transplantation, 1999 Glomerulonephritis (GN), diabetic nephropathy, and uli. The expression efficiency into the glomeruli was hypertension are the major causes of chronic renal approximately 35%. Over-expression of TGF-b caused failure that finally require renal replacement therapy.
Y, Isaka +4 more
openaire +2 more sources
Collapsing glomerulopathy following COVID 19 infection; a mini-review to the recent data [PDF]
Journal of Preventive Epidemiology, 2023 Collapsing glomerulopathy has been delineated as the most common morphological feature in COVID-19 individuals presenting with rapidly progressive renal failure and massive proteinuria. This condition, also known as COVID-19-associated nephropathy, has a
Leila Alem +4 more
doaj +1 more source
Murine models of renal disease: Possibilities and problems in studies using mutant mice [PDF]
, 2000 The elucidation of the pathogenesis of human renal disease at the molecular level has been facilitated by the growing field of gene targeting and the development of mouse strains with single-gene deletions - the `knock-out' mice. Experimental nephrology,
Anders, Hans-Joachim +1 more
core +1 more source
Российский журнал гериатрической медицины, 2021 Individuals age >65 years old are the fastest expanding population demographic throughout the developed world. Consequently, more aged patients than before are receiving diagnoses of impaired renal function and nephrosclerosis.
L. I. Merkusheva +2 more
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Specific renal parenchymal-derived urinary extracellular vesicles identify age-associated structural changes in living donor kidneys [PDF]
Journal of Extracellular Vesicles, 2016 Non-invasive tests to identify age and early disease-associated pathology within the kidney are needed. Specific populations of urinary extracellular vesicles (EVs) could potentially be used for such a diagnostic test.
Anne E. Turco +8 more
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