Results 101 to 110 of about 68,068 (346)

Olfactory‐to‐Entorhinal Network Dysrhythmias Drive Parkinson's Cognitive Impairment Through Frequency‐Specific Oscillatory Decoupling

Advanced Science, EarlyView.
Wang et al reveal that in the olfactory system, the selective impairment of gamma‐driven Barcode features underlying early olfactory deficits, while the selective impairment of theta‐driven Barcode features underlying later cognitive deficits, further establishing cross‐network gamma oscillations in the early stage as a biomarker of later cognitive ...
Shuaishuai Wang, Zhishen Cai, Xingfeng Mao, Yixuan Zhang, Yunlong Pan, Jiawen Cheng, Xuechun Wang, Hengyi Song, Sasaki Takuya, Ming Lu, Gang Hu, Xiuxiu Liu, Yingmei Lu, Feng Han   +13 more
wiley   +1 more source

Pengaruh Hiperglikemia terhadap Gambaran Histopatologis Glomerulus Mencit (Mus musculus Linn) yang Diinduksi Aloksan

Jurnal Kesehatan Andalas, 2015
AbstrakHiperglikemia menjadi ancaman serius karena berdampak buruk terhadap keluaran klinis karena dapat menyebabkan gangguan fungsi imun serta lebih rentan terkena infeksi, perburukan sistem kardiovaskuler, trombosis, peningkatan inflamasi, disfungsi ...
Melati Setia Ningsih, Eryati Darwin, Erlina Rustam   +2 more
doaj  

Modelling Renal Filtration and Reabsorption Processes in a Human Glomerulus and Proximal Tubule Microphysiological System [PDF]

, 2021
Stephanie Zhang, Gretchen J. Mahler
openalex   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

WT1 Is Necessary for the Proliferation and Migration of Cells of Renin Lineage Following Kidney Podocyte Depletion

Stem Cell Reports, 2017
Wilms' tumor suppressor 1 (WT1) plays an important role in cell proliferation and mesenchymal-epithelial balance in normal development and disease. Here, we show that following podocyte depletion in three experimental models, and in patients with focal ...
Natalya V. Kaverina, Diana G. Eng, Andrea D. Largent, Ilse Daehn, Anthony Chang, Kenneth W. Gross, Jeffrey W. Pippin, Peter Hohenstein, Stuart J. Shankland   +8 more
doaj   +1 more source

Korelasi Antara Penurunan Laju Filtrasi Glomerulus Dengan Beratnya Anemia Pada Penyakit Ginjal Kronik Di RSUD DR. Sayyidiman Magetan [PDF]

, 2014
Latar Belakang: Penyakit ginjal kronik (PGK) merupakan masalah kesehatan diseluruh dunia yang semakin meningkat jumlahnya. Penurunan laju filtrasi glomerulus, serta kelainan struktur maupun fungsi ginjal yang irreversible dan berlangsung kronik ...
, dr. Retno Suryaningsih, Sp. PD, , dr. Safari Wahyu Jatmiko, Apriani, Yustisia   +2 more
core  

Dipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes

Advanced Science, EarlyView.
By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.
Jiale Dong, Ting Guo, Yi Huang, Yangchun Ma, Weijin Chen, Jie Xue, Jun Jiang, Enhui Dong, Yue Kong, Hang Ding, Wenlong Zhang, Shutao Ma   +11 more
wiley   +1 more source

Process of Glucose Increases Rather Than Constant High Glucose Was the Main Cause of Abnormal Glucose Induced Glomerulus Epithelial Cells Inflammatory Response [PDF]

, 2022
Jiancheng Qi, Weiyu Liu, Linli Gan, Hongrui Guo, Yue Xie, Liping Gou, Dongjie Cai, Jizong Zhang, Junliang Deng, Zhihua Ren, Jing Fang, Zhicai Zuo   +11 more
openalex   +1 more source

Ultrasound‐Boosted Liposomal Prodrug Overcomes Age‐Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy

Advanced Science, EarlyView.
The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen, Junjun Xu, Jian Chen, Jue Hu, Xiaobo Xuan, Haifang Cai, Mingdong Yang, Zhuxian Zhou, Guowei Wang   +8 more
wiley   +1 more source

GLOMERULAR CAPILLARY GROWTH AND CELLULAR HYPERPLASIA IN A MODEL OF FOCAL AND SEGMENTAL GLOMERULOSCLEROSIS

Image Analysis and Stereology, 2011
Focal and segmental glomerulosclerosis (FSGS) is a chronic renal disorder characterized by segmental glomerular lesions and widespread podocyte foot process effacement.
John F Bertram, Meroe M Cahill
doaj   +1 more source