Results 161 to 170 of about 117,976 (202)
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Microcirculation, 2019
AbstractGLP‐1 and GLP‐2 are gut‐derived hormones used in the treatment of diabetes type‐2 and short bowel syndrome, respectively. GLP‐1 attenuates insulin resistance and GLP‐2 reduces enterocyte apoptosis and enhances crypt cell proliferation in the small intestine. In addition, both hormones have vasoactive effects and may be useful in situations with
Nikolaj Nerup +5 more
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AbstractGLP‐1 and GLP‐2 are gut‐derived hormones used in the treatment of diabetes type‐2 and short bowel syndrome, respectively. GLP‐1 attenuates insulin resistance and GLP‐2 reduces enterocyte apoptosis and enhances crypt cell proliferation in the small intestine. In addition, both hormones have vasoactive effects and may be useful in situations with
Nikolaj Nerup +5 more
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Structural Determinants for Activity of Glucagon-like Peptide-2
Biochemistry, 2000Glucagon-like peptide-2 (GLP-2) is a 33 amino acid gastrointestinal hormone that regulates epithelial growth in the intestine. Dipeptidylpeptidase IV cleaves GLP-2 at the position 2 alanine, resulting in the inactivation of peptide activity. To understand the structural basis for GLP-2 action, we studied receptor binding and activation for 56 GLP-2 ...
M P, DaCambra +5 more
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Influence of glucagon-like peptide 2 on energy homeostasis
Peptides, 2016Glucagon like peptide-2 (GLP-2) is a gastrointestinal hormone released from enteroendocrine L-type cells together with glucagon like peptide-1 in response to dietary nutrients. GLP-2 acts through a specific receptor, the GLP-2 receptor, mainly located in the gut and in the brain.
Sara Baldassano +2 more
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Glucagon like peptide-2 and neoplasia; a systematic review
Expert Review of Gastroenterology & Hepatology, 2017Glucagon like peptide-2 is synthesized from enteroendocrine L cells primarily located in the ileum and large intestine. GLP-2 stimulates crypt cell proliferation, increases intestinal blood flow, enhances gut barrier function, induces mucosal healing, and exerts an anti-apoptotic effect.
Ring, Linea Landgrebe +4 more
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Glucagon-like peptide 2 inhibits ghrelin secretion in humans
Regulatory Peptides, 2006The growth hormone secretagogue receptor ligand ghrelin is known to play a pivotal role in the central nervous control of energy homeostasis. Circulating ghrelin levels are high under fasting conditions and decline after meal ingestion, but the mechanisms underlying the postprandial drop in ghrelin levels are poorly understood.
Banasch, Matthias +6 more
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Glucagon-Like Peptide 2 (GLP-2), An Intestinotrophic Mediator
Current Protein & Peptide Science, 2004Glucagon-like peptide 2 (GLP-2) is a newly discovered gastrointestinal peptide with 33% sequence homology to glucagon. GLP-2 has attracted interest because of its potent intestinotrophic endocrine/paracrine actions. The peptide, consisting of 33-amino-acid, results from expression of the glucagon gene in the enteroendocrine L-cells of the intestinal ...
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Glucagon-like peptide-1 analogues for type 2 diabetes
BMJ, 2011#### Case scenario A 58 year old woman attends a diabetes clinic with type 2 diabetes of seven years’ duration and no history of macrovascular disease. She is obese (body mass index 37), but says she eats a healthy diet and describes this. Her blood pressure is 134/78 mm Hg, and she has microalbuminuria, but normal renal function and a lipid profile ...
John P H, Wilding, Kevin, Hardy
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Journal of Molecular Recognition, 2012
Glucagon‐like peptide‐2 (GLP‐2) is a member of the glucagon multigene family that is produced by intestinal enteroendocrine cells in response to food intake. GLP‐2 stimulates growth of the intestinal epithelium, enhances its barrier functions, and increases nutrient uptake.
Audrey E, Baker +7 more
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Glucagon‐like peptide‐2 (GLP‐2) is a member of the glucagon multigene family that is produced by intestinal enteroendocrine cells in response to food intake. GLP‐2 stimulates growth of the intestinal epithelium, enhances its barrier functions, and increases nutrient uptake.
Audrey E, Baker +7 more
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Clinical endocrinology and metabolism. Glucagon-like peptide-1 and glucagon-like peptide-2.
Best practice & research. Clinical endocrinology & metabolism, 2005The glucagon-like peptides (glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2)) are released from enteroendocrine cells in response to nutrient ingestion. GLP-1 enhances glucose-stimulated insulin secretion and inhibits glucagon secretion, gastric emptying and feeding. GLP-1 also has proliferative, neogenic and antiapoptotic effects on
Laurie L, Baggio, Daniel J, Drucker
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Glucagon and Glucagon-Like Peptides 1 and 2
2009The glucagon gene is expressed not only in the alpha cells of the pancreatic islets but also in the endocrine cells of the intestinal epithelium (so-called L-cells), and in certain neurons of the brain stem. Whereas in the pancreas, glucagon, the hyperglycaemic hormone, is cleaved out of the 160 amino acid precursor, proglucagon, leaving behind ...
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