Results 1 to 10 of about 42,175 (206)
The Glucagon-Like Peptides [PDF]
Endocrine Reviews, 1999 I. Introduction II. History of the Incretin Concept: Discovery of Gastric Inhibitory Polypeptide III. Discovery of GLP-1 IV. Structures of GLPs and Family of Glucagon-Related Peptides V. Tissue Distribution of the Expression of GLPs A. Pancreatic α-cells B. Intestinal L cells C. Central nervous system VI. Proglucagon Biosynthesis A.
T J, Kieffer, J F, Habener
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Frontiers in Endocrinology, 2021 The mammalian proglucagon gene (Gcg) encodes three glucagon like sequences, glucagon, glucagon-like peptide-1 (GLP-1), and glucagon-like peptide-2 that are of similar length and share sequence similarity, with these hormones having cell surface receptors,
David M. Irwin, David M. Irwin
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Dose-dependent effects of a soluble dietary fibre (pectin) on food intake, adiposity, gut hypertrophy and gut satiety hormone secretion in rats [PDF]
, 2015 Acknowledgments We thank Donna Wallace and Animal House staff at the Rowett Institute of Nutrition and Health for the daily care of experimental rats and for the body weight, food intake and MRI measurements.Peer reviewedPublisher ...
Adam, Clare L +4 more
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Postprandial Dynamics of Proglucagon Cleavage Products and Their Relation to Metabolic Health
Frontiers in Endocrinology, 2022 IntroductionWhile oral glucose ingestion typically leads to a decrease in circulating glucagon levels, a substantial number of persons display stable or rising glucagon concentrations when assessed by radioimmunoassay (RIA).
Robert Wagner +31 more
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Liraglutide; A New Hope for Obese Diabetics [PDF]
JLUMHS, 2020 OBJECTIVE: To assess the effectiveness of liraglutide in reducing weight and Glycated haemoglobin (HbA1c) in type 2 diabetic patients. METHODOLOGY: This analytical observational study was conducted at Jinnah medical college hospital Karachi Pakistan ...
Ajeet Kumar +6 more
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The Glucagon-Like Adipokinetic Hormone in Drosophila melanogaster – Biosynthesis and Secretion
Frontiers in Physiology, 2021 Metabolic homeostasis requires the precise regulation of circulating sugar titers. In mammals, homeostatic control of circulating sugar titers requires the coordinated secretion and systemic activities of glucagon and insulin.
Bryon N. Hughson
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Nature Communications, 2021 Incretin hormones regulate insulin and glucagon secretion in mammals, but similar peptides have not been characterized in invertebrates. Here the authors show that neuropeptide F functions similar to mammalian incretin in fruit flies, responding to sugar
Yuto Yoshinari +9 more
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Proglucagon-Derived Peptides as Therapeutics
Frontiers in Endocrinology, 2021 Initially discovered as an impurity in insulin preparations, our understanding of the hyperglycaemic hormone glucagon has evolved markedly over subsequent decades.
Ryan A. Lafferty +4 more
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Fertility and pregnancy-associated ß-cell proliferation in mice deficient in proglucagon-derived peptides. [PDF]
PLoS ONE, 2012 Proglucagon, which is encoded by the glucagon gene (Gcg), is the precursor of several peptide hormones, including glucagon and glucagon-like peptide 1 (GLP-1).
Chisato Sugiyama +5 more
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Proglucagon-Derived Peptides Expression and Secretion in Rat Insulinoma INS-1 Cells
Frontiers in Cell and Developmental Biology, 2020 Rat insulinoma INS-1 cells are widely used to study insulin secretory mechanisms. Studies have shown that a population of INS-1 cells are bi-hormonal, co-expressing insulin, and proglucagon proteins.
Ana Acosta-Montalvo +17 more
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