Results 31 to 40 of about 42,175 (206)
The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach [PDF]
, 2013 The calcitonin gene-related peptide (CGRP) receptor is a complex of a calcitonin receptor-like receptor (CLR), which is a family B G-protein-coupled receptor (GPCR) and receptor activity modifying protein 1.
Alex C. Conner +13 more
core +2 more sources
Minireview: The Glucagon-Like Peptides [PDF]
Endocrinology, 2001 The glucagon-like peptides GLP-1 and GLP-2 are produced in enteroendocrine L cells of the small and large intestine and secreted in a nutrient-dependent manner. GLP-1 regulates nutrient assimilation via inhibition of gastric emptying and food intake. GLP-1 controls blood glucose following nutrient absorption via stimulation of glucose-dependent insulin
openaire +2 more sources
The role of gut-hypothalamus axis for feeding regulation
Journal of Physical Fitness and Sports Medicine, 2013 The gastrointestinal tract secretes several peptide hormones that regulate food intake by transmitting signals to the central nervous system related to energy homeostasis.
Koji Toshinai
doaj +1 more source
Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders
Frontiers in Neuroscience, 2014 Peptides synthesized in endocrine cells in the gastrointestinal tract and neurons are traditionally considered regulators of metabolism, energy intake, and appetite. However, recent work has demonstrated that many of these peptides act on corticostriatal-
Chelsea A Vadnie +5 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Enteroendocrine cells directly integrate signals of nutrient content within the gut lumen with distant hormonal responses and nutrient disposal via the production and secretion of peptides, including glucose-dependent insulinotropic polypeptide (GIP ...
Nadya M. Morrow +7 more
doaj +1 more source
JACC: Basic to Translational Science, 2016 Glucagon-like peptide-1-(7-36) amide (GLP-1) is a human incretin hormone responsible for the release of insulin in response to food. Pre-clinical and human physiological studies have demonstrated cardioprotection from ischemia-reperfusion injury. It can reduce infarct size, ischemic left ventricular dysfunction, and myocardial stunning.
Joel P. Giblett, BM, BSc +3 more
openaire +3 more sources
Mice Deficient in Proglucagon-Derived Peptides Exhibit Glucose Intolerance on a High-Fat Diet but Are Resistant to Obesity. [PDF]
PLoS ONE, 2015 Homozygous glucagon-GFP knock-in mice (Gcggfp/gfp) lack proglucagon derived-peptides including glucagon and GLP-1, and are normoglycemic. We have previously shown that Gcggfp/gfp show improved glucose tolerance with enhanced insulin secretion.
Yusuke Takagi +6 more
doaj +1 more source
The associations of gut microbiota, endocrine system and bone metabolism
Frontiers in Microbiology, 2023 Gut microbiota is of great importance in human health, and its roles in the maintenance of skeletal homeostasis have long been recognized as the “gut-bone axis.” Recent evidence has indicated intercorrelations between gut microbiota, endocrine system and
Ye Tu +6 more
doaj +1 more source
Recombinant Incretin-Secreting Microbe Improves Metabolic Dysfunction in High-Fat Diet Fed Rodents [PDF]
, 2017 peer-reviewedThe gut hormone glucagon-like peptide (GLP)-1 and its analogues represent a new generation of anti-diabetic drugs, which have also demonstrated propensity to modulate host lipid metabolism.
Cryan, John F. +13 more
core +5 more sources
A neuronal relay mediates a nutrient responsive gut/fat body axis regulating energy homeostasis in adult Drosophila [PDF]
, 2019 The control of systemic metabolic homeostasis involves complex inter-tissue programs that coordinate energy production, storage, and consumption, to maintain organismal fitness upon environmental challenges.
Bauer, Christin +8 more
core +1 more source