Results 1 to 10 of about 385 (124)

Use of glucarpidase (carboxypeptidase‐G2) in pediatric cancer patients: 11‐year experience of a tertiary center [PDF]

eJHaem, 2023
Methotrexate is an essential drug in the treatment of childhood cancer that is not exempt from toxicities. Glucarpidase is a drug used to reduce the toxic concentration of plasma methotrexate in patients with delayed elimination or at risk of toxicity ...
Rocío Vila, Alba Rubio‐San‐Simón, Pablo Zubiaur, Marcos Navares‐Gómez, Patricia Gómez‐Hernández, Begoña Arce, Luis Madero   +6 more
doaj   +3 more sources

Glucarpidase to combat toxic levels of methotrexate in patients

Therapeutics and Clinical Risk Management, 2012
Jacalyn M GreenDepartment of Biochemistry, Midwestern University, IL, USAAbstract: In January 2012, glucarpidase (Voraxaze®) received approval from the US Food and Drug Administration for intravenous treatment of toxic plasma methotrexate ...
Green JM
doaj   +8 more sources

Glucarpidase for treatment of high-dose methotrexate toxicity.

Blood
Abstract High-dose methotrexate (MTX) results in high rates of acute kidney injury (AKI), neutropenia, and hepatotoxicity. Glucarpidase is a recombinant enzyme that cleaves MTX, but clinical data supporting its use are scarce.
Gupta S, Kaunfer SA, Chen KL, Dias JA, Vijayan A, Rajasekaran A, Prosek JM, Truong HL, Wood A, Bassil C, Renaghan AD, Shah CV, Zhang J, Glezerman I, Carlos C, Kelly K, Passero CJ, Drappatz J, Abudayyeh A, Shin DS, Sperati CJ, Yelvington BJ, Kanduri SR, Neyra JA, Edmonston D, Shirali AC, Bansal A, Geara A, Mithani Z, Ziolkowski SL, Rashidi A, Jakubowski J, Pujari A, Bond DA, Dotson E, Wall S, Patton J, Barreto JN, Herrmann SM, Sheikh MS, Baz R, Lee J, Lucchesi N, Kolman M, Rasheed MA, Afzal A, Kang D, Mahesh A, Hsu RK, Nicolaysen A, Tefera K, Schretlen C, Miller RM, Velez JC, Flannery AH, Aklilu AM, Anand S, Chandrasekhara S, Donley V, Patel A, Ni J, Krishnamurthy S, Ali R, Yilmam OA, Wells SL, Ortega JL, Green-Lingren OL, Leaf RK, Sise ME, Nayak L, LaCasce AS, Leung N, Leaf DE.   +72 more
europepmc   +4 more sources

Effective high-dose methotrexate toxicity reversal using fixed-dose glucarpidase in obese patients: a case series [PDF]

Journal of Medical Case Reports
Background This case report and literature review present two instances of delayed methotrexate clearance in individuals who were successfully managed using fixed dosing versus weight-based dosing of glucarpidase.
John Grofvert, Brett Van Rossum, Erin Pettijohn, Mohammad Mobayed, Devon Stonerock   +4 more
doaj   +2 more sources

Half-dose glucarpidase: an effective rescue for toxic methotrexate plasma concentrations in a patient with bilateral primary vitreoretinal lymphoma [PDF]

Annals of Hematology
Primary vitreoretinal lymphoma (PVRL) is a rare, aggressive subtype of central nervous system lymphoma that initially presents in the eye. High-dose methotrexate (HD-MTX) is a key component of systemic therapy, but its use can be complicated by ...
Ángela González-Román, Thais Lizondo, Carla Bastida, Inés Monge-Escartín, Gisela Riu, Esther Carcelero, Eduardo Aguilar, Anna Gaya, Dolors Soy   +8 more
doaj   +2 more sources

Case Report: Serum methotrexate monitoring by immunoassay: confusion by by-product, confusion by antidote [PDF]

Frontiers in Oncology, 2023
Methotrexate is a commonly used agent in the treatment of many malignancies and rheumatologic/inflammatory diseases. Working by inhibiting dihydrofolate reductase and thereby preventing eventual formation of tetrahydrofolate, methotrexate inhibits ...
Aditya Sharma, Philip Benoit, Frederick Lansigan, David Nierenberg   +3 more
doaj   +2 more sources

Glucarpidase Intervention for Delayed Methotrexate Clearance [PDF]

Annals of Pharmacotherapy, 2014
Objective: To review and evaluate the current published literature on the effectiveness and safety of glucarpidase and to determine its potential role in clinical practice. Data Sources: A PubMed literature search from 1946 to January 2014 was performed using the search terms carboxypeptidase G2, glucarpidase, high-dose methotrexate, and leucovorin ...
Jennifer L, Cavone, Daisy, Yang, Alice, Wang   +2 more
exaly   +5 more sources

Glucarpidase for Treating Adults with Delayed Methotrexate Elimination Due to Impaired Renal Function: An Economic Simulation Analysis [PDF]

ClinicoEconomics and Outcomes Research, 2023
Jaya Kala,1,* Rebecca Nelson,2,* Christopher Drudge,3 Allen Zhou,3 Suzanne Ward,4 Megan Bourque3 1University of Texas Health Science Center, Houston, TX, USA; 2Moffitt Cancer Center and Research Institute, Tampa, FL, USA; 3Value and Evidence ...
Kala J, Nelson R, Drudge C, Zhou A, Ward S, Bourque M   +5 more
doaj   +2 more sources

Consensus on managing delayed methotrexate elimination in high-dose therapy: insights from the Middle East [PDF]

Frontiers in Oncology
IntroductionHigh-dose methotrexate (HDMTX) therapy is a cornerstone in treating pediatric and adult cancers, namely, acute lymphoblastic leukemia, non-Hodgkin lymphoma, and osteosarcoma, due to its capability to penetrate the blood–brain barrier. Despite
Mubarak Al Manasour, Mubarak Al Manasour, Ahmad Absi, Ahmad Alhuraiji, Ahmad Alhuraiji, Muhammad Faisal Khanani, Kayane Mheidly, Mohamed Elsaid, Walid Ballourah, Murtadha Al-Khabori, Naser Al Zain, Naser Al Zain, Nisreen Khalifa, Rawad Rihani, Shaker Abdallah, Yasser Wali   +15 more
doaj   +2 more sources

Recovery of methotrexate-induced anuric acute kidney injury after glucarpidase therapy [PDF]

SAGE Open Medical Case Reports, 2017
Objectives: This case report describes two cases of high-dose methotrexate–induced nephrotoxicity: death in the case of conventional supportive care and successful renal function recovery in a patient treated with glucarpidase and continuous dialysis ...
James Harms, Ayaz Khawaja, Maria Taylor, Xiaosi Han, Michal Mrug   +4 more
doaj   +3 more sources