Results 41 to 50 of about 721 (165)

methotrexate renal clearance by low dose dopamine in severe nephrotoxicity [PDF]

, 2016
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Antonio Dal Canton, Fabrizio Grosjean, Manuel Gotti, Marianna Rossi, Vincenzo Sepe   +4 more
core   +2 more sources

High-Dose Methotrexate at All Ages: Safety, Efficacy, and Outcomes from the HDMTX European Registry. [PDF]

Cancers (Basel)
Objectives: To determine the incidence of delayed methotrexate elimination (DME) and acute kidney injury (AKI) and their associations with clinical outcomes in patients receiving high-dose methotrexate (HDMTX) for cancer treatment.
Pourroy B, Aumente MD, Koenecke C, Stanulla M, Ferreri AJM, Murciano-Carillo T, Dandapani M, Ritzmann TA, Barba P, Chatelut E, Ingley KM, Morris E, Schorb E, Liebig S, Schwartz S, Howard SC, Combs R, Tentoni N, Lowe J, Villanueva G, Sampor C, Hwang M, Rizzari C.   +22 more
europepmc   +3 more sources

Studies on Ligand Directed Enzyme Prodrug Therapy and Production of Long Acting Protein Therapeutics for Targeted Cancer Treatment [PDF]

, 2020
Targeting cancer therapy is one of the powerful tools that has been implemented for cancer treatment. One of the targeted cancer strategies is known as Antibody Directed Enzyme Prodrug Therapy (ADEPT).
Al-Mansoori, Layla
core   +1 more source

Toxicity of pemetrexed during renal impairment explained-Implications for safe treatment [PDF]

, 2021
Item does not contain fulltextPemetrexed is an important component of first line treatment in patients with non-squamous non-small cell lung cancer. However, a limitation is the contraindication in patients with renal impairment due to hematological ...
Aerts, J.G.J.V., Biesma, B., Boosman, R.J., Burgers, J.A., Croes, S., de Rouw, N., Dingemans, A.M.C., Dorlo, T.P.C., Hendriks, L.E.L., Huitema, A.D.R., Mathijssen, R.H.J., Ter Heine, R., van den Heuvel, M.M.   +12 more
core   +1 more source

Dendritic Molecular Baskets for Selective Binding of Toxic Methotrexate

Angewandte Chemie, Volume 137, Issue 9, February 24, 2025.
Dendritic molecular baskets are biocompatible cavitands capable of including toxic methotrexate (MTX) in their aromatic cavity. The binding is chemoselective with the complex forming in competitive cell media. With the unique mode of recognition and modular structure, dendritic baskets are leading candidates for developing effective antidotes against ...
Nitesh Kumar, Tyler J. Finnegan, Sagarika Taneja, Darian C. Rostam, Alexandar L. Hansen, Carson E. Ward, Sefa Uçar, Jon R. Parquette, Jovica D. Badjić   +8 more
wiley   +2 more sources

Eight-year national multicenter experience on the use of glucarpidase as effective rescue therapy for delayed methotrexate elimination after high-dose methotrexate cycles administered in children with hemato-oncological diseases

EJC Paediatric Oncology
Background: High-dose methotrexate (HDMTX) for cancer treatment can be complicated by delayed methotrexate elimination (DME) and associated acute kidney injury (AKI).
Nicolò Peccatori, Marta Coppola, Antonella Colombini, Daniela Silvestri, Nicoletta Bertorello, Valentina Kiren, Fraia Melchionda, Rosamaria Mura, Daniela Onofrillo, Simona Gobbi, Raffaele Mattera, Luciana Vinti, Tommaso Casini, Nicola Santoro, Domenico Sperlì, Carmelita D’Ippolito, Valentino Conter, Andrea Biondi, Carmelo Rizzari   +18 more
doaj   +1 more source

High-dose methotrexate

Indian Journal of Medical and Paediatric Oncology, 2019
High-dose methotrexate (HDMTX) is defined as methotrexate dose of ≥500 mg/m2. It is used in the treatment of acute lymphoblastic leukemia, osteosarcoma, and primary central nervous system lymphoma.
Manikandan Dhanushkodi
doaj   +1 more source

Case report on toxicity of methotrexate in tubal ectopic pregnancy [PDF]

, 2020
Ectopic pregnancy is defined as pregnancy outside uterine cavity. Of all ectopic pregnancy, tubal ectopic is most common. Most cases today are diagnosed early and hence timely treatment is possible.
Lodha, Surbhi, Mali, Kimaya
core   +2 more sources

High dose methotrexate and extended hours high-flux hemodialysis for the treatment of primary central nervous system lymphoma in a patient with end stage renal disease [PDF]

, 2012
This report discusses the case of a 52 year old female with post-transplant lymphoproliferative disorder, confined to the central nervous system, which was managed with high dose methotrexate (HDMTX) in the context of end stage renal disease. The patient
Mutsando, Howard, Fahim, Magid, Gill, Devinder S., Hawley, Carmel M., Johnson, David W., Maher, K. Gandhi, Marlton, Paula V., Mar Fan, Helen G., Mollee, Peter N.   +8 more
core  

Production of novel protein therapeutics to improve targeted cancer therapy [PDF]

, 2019
Cancer is one of the leading cause of death worldwide and in Qatar. Conventional cancer therapies are the main stream for treatment but with severe side effects.
Al-Qahtani, Alanod
core   +5 more sources