Results 51 to 60 of about 721 (165)
DAMPAned Methotrexate: A Case Report and Review of the Management of Acute Methotrexate Toxicity
Canadian Journal of Kidney Health and Disease, 2019 Rationale: Consensus guidelines on the management of methotrexate-induced nephrotoxicity using glucarpidase (Voraxaze) may be relatively unfamiliar to the nephrology community.
Ann Young +7 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1405-1421, December 2025.Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami +2 more
wiley +1 more source
The Value Driven Pharmacist: Basics of Access, Cost, and Quality 2nd Edition [PDF]
, 2020 https://digitalcommons.butler.edu/butlerbooks/1017/thumbnail ...
Devine, Trish +5 more
core +1 more source
Pediatric Blood &Cancer, Volume 72, Issue 7, July 2025.ABSTRACT High‐dose methotrexate dosage and infusion durations differ across treatment protocols for pediatric leukemia, lymphoma, and osteosarcoma. Supportive care interventions are dependent on a patient's elimination of methotrexate (MTX). Therefore, it is important to establish the expected MTX elimination across protocols.
Zachary L. Taylor +11 more
wiley +1 more source
Accidental Chronic Poisoning with Methotrexate; Report of Two Cases [PDF]
, 2017 Methotrexate has been used widely in dermatology, oncology and rheumatology fields. However, methotrexate-induced mucocutaneous lesions may occur in rare cases.
Babaei Zarch, Mojtaba +4 more
core +3 more sources
Escherichia coli in the production of biopharmaceuticals
Biotechnology and Applied Biochemistry, Volume 72, Issue 2, Page 528-541, April 2025.Abstract Escherichia coli has shouldered a massive workload with the discovery of recombinant DNA technology. A new era began in the biopharmaceutical industry with the production of insulin, the first recombinant protein, in E. coli and its use in treating diabetes. After insulin, many biopharmaceuticals produced from E. coli have been approved by the
İbrahim İncir, Özlem Kaplan
wiley +1 more source
Contemplation on new drug approvals by U.S. FDA, 2011-2015 [PDF]
, 2016 Background: The U.S Food and Drugs Administration (FDA) is the world's leading drug regulatory authority. There are reports of more product pipelines in oncology therapy area.
Kataria, Bhaven C. +4 more
core +2 more sources
Strategies for the production of long-acting therapeutics and efficient drug delivery for cancer treatment [PDF]
, 2019 Protein therapeutics play a significant role in treating many diseases. They, however, suffer from patient's proteases degradation and antibody neutralization which lead to short plasma half-lives.
AlQahtani, Alanod D. +3 more
core +1 more source
Clinical and Translational Science, Volume 18, Issue 2, February 2025.ABSTRACT High‐dose methotrexate (HD‐MTX) infusions are commonly used to consolidate remission in children with acute lymphoblastic leukemia (ALL). We investigate the potential role of candidate polymorphisms in SLCO1B1 (rs4149056 and rs2306283), ABCB1 (rs1045642), ABCC2 (rs717620), ABCC3 (rs9895420), and ABCC4 (rs7317112) drug transporters genes on HD ...
Stefania Braidotti +15 more
wiley +1 more source
ClinicoEconomics and Outcomes Research, 2019 Berna Demiralp,1 Lane Koenig,1 Jaya Kala,2 Chaoling Feng,1 Elizabeth G Hamlett,1 Marie Steele-Adjognon,1 Suzanne Ward3 1KNG Health Consulting, Rockville, MD, USA; 2University of Texas Health Science Center, University of Texas MD Anderson Cancer Center ...
Demiralp B +6 more
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