Results 61 to 70 of about 721 (165)
Hypoalbuminemia in children with acute lymphoblastic leukemia: relation to asparaginase therapy and impact on high dose methotrexate elimination [PDF]
PurposeHigh-dose methotrexate (HDMTX) therapy is an important component in treatment regimens for acute lymphoblastic leukemia (ALL). Courses are associated with a risk of renal injury, delayed elimination, and increased systemic toxicity.
Christensen, Sophie Rex +5 more
core +2 more sources
The Challenge of Primary Central Nervous System Lymphoma [PDF]
, 2016 Primary central nervous system (CNS) lymphoma is a challenging subtypes of aggressive non-Hodgkin lymphoma. Emerging clinical data suggest that optimized outcomes are achieved with dose-intensive CNS-penetrant chemotherapy and avoiding whole brain ...
Carnevale, Julia, Rubenstein, James L
core +1 more source
Methotrexate: A Multifaceted Weapon in Dermatologists’ Hands
Dermatologic Therapy, Volume 2025, Issue 1, 2025.Methotrexate is a well‐known chemotherapeutic agent, widely used alone or in combination with other drugs in the treatment of cancer. Methotrexate applications in dermatology have significantly expanded over the years. Methotrexate is an established treatment modality for psoriasis; other indications include vitiligo, atopic dermatitis, immunobullous ...
Hagar Nofal +6 more
wiley +1 more source
Cancer Medicine, Volume 13, Issue 21, November 2024.Rashes, fever, and neutropenia were independent risk factors for high‐dose methotrexate‐induced oral mucositis. Female sex and acute kidney injury were associated with recurrent mucositis. ABSTRACT Background Oral mucositis affects about 20% of children undergoing high‐dose methotrexate (HDMTX) for acute lymphoblastic leukemia (ALL), despite existing ...
Zhongbo Hu +6 more
wiley +1 more source
Clinical Dermatology ReviewAcute methotrexate (MTX) toxicity is most commonly due to overdose of the drug, which may be due to the patient's noncompliance to doctor's orders or physician's prescription error. Other causes include acute renal failure, concomitant use of other drugs,
Shiva Shankar Marri +4 more
doaj +1 more source
Medicine ScienceDrugs used for treatment in the clinic also have side effects. As one of these drugs, Methotrexate (MTX) is a folate antagonist antimetabolite that has a wide range of uses in diseases such as cancer and non-cancer autoimmune diseases, inflammatory ...
Seyda Secgin, Tahir Kahraman
doaj +1 more source
Electromembrane extraction of methotrexate and its metabolites [PDF]
, 2021 Within pharmaceutical analysis, sample preparation is essential to make a sample compatible with the chosen analytical instrument, prevent contamination and damage of the instrument, and to avoid interference from matrix substances in biological samples.
Hay, Anne Oldeide
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Guidelines for treatment of renal injury during cancer chemotherapy 2016 [PDF]
, 2018 journal ...
Ando Yuichi +16 more
core +2 more sources
Revista Cubana de Hematología, Inmunología y Hemoterapia, 2012 El metotrexato es un antimetabolito que inhibe competitivamente la enzima dihidrofolato reductasa y posee actividad antiproliferativa e inmunosupresora, por lo que se emplea en el tratamiento de diferentes hemopatías malignas.
Juan Carlos Jaime-Fagundo +2 more
doaj
Efficacy And Safety Of Glucarpidase For Routine Use After High Dose Methotrexate In Patients With Bone Sarcoma [PDF]
, 2013 Background: High-dose methotrexate (HD-MTX) is an essential component of osteosarcoma treatment. Despite supportive measures MTX-related toxicity results in delays in subsequent chemotherapy administration and potentially reduced treatment efficacy ...
Perisoglou, M
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