Results 31 to 40 of about 721 (165)

Treatment of acute kidney injury in cancer patients [PDF]

, 2021
Acute kidney injury (AKI), either of pre-renal, renal or post-renal origin, is an important complication in cancer patients, resulting in worse prognosis, withdrawal from effective oncological treatments, longer hospitalizations and increased costs.
Braet, Pauline, Cosmai, Laura, Pirovano, Marta, Sartò, Giulia Vanessa Re, Sprangers, Ben   +4 more
core   +2 more sources

Development of a population pharmacokinetics and pharmacodynamics model of glucarpidase rescue treatment after high-dose methotrexate therapy

Frontiers in Oncology, 2023
IntroductionGlucarpidase (CPG2) reduces the lethal toxicity of methotrexate (MTX) by rapid degradation.MethodsIn this study, a CPG2 population pharmacokinetics (popPK) analysis in healthy volunteers (phase 1 study) and a popPK-pharmacodynamics (popPK-PD)
Yutaka Fukaya, Toshimi Kimura, Yukihiro Hamada, Kenichi Yoshimura, Hiroaki Hiraga, Yuki Yuza, Atsushi Ogawa, Junichi Hara, Katsuyoshi Koh, Atsushi Kikuta, Yuhki Koga, Hiroshi Kawamoto   +11 more
doaj   +1 more source

Role of molecular adsorbent recirculating system in methotrexate-induced acute liver failure: a case report and literature review. [PDF]

Front Pediatr
We describe the case of a 14-year-old girl with osteosarcoma who was treated with high-dose methotrexate (12 g/m2). Twenty-four hours after the infusion, her plasma methotrexate concentration was elevated at 937 μmol/L (normal < 10 µmol/L).
Corbisier T, Von Bueren AO, Breunis WB, Grazioli S.   +3 more
europepmc   +4 more sources

Ethnic-Specific Predictors of Neurotoxicity Among Patients With Pediatric Acute Lymphoblastic Leukemia After High-Dose Methotrexate [PDF]

, 2023
High-dose methotrexate (HD-MTX; 5,000 mg/m2) is an important component of curative therapy in many treatment regimens for high-risk pediatric acute lymphoblastic leukemia (ALL).
Bernhardt, Melanie Brooke, Brown, Austin L, Gramatges, Maria Monica, Harris, Rachel D, Lupo, Philip J, Rabin, Karen R, Schafer, Eric S, Scheurer, Michael E, Taylor, Olga A, Zobeck, Mark C   +9 more
core   +2 more sources

Preventive strategies for acute kidney injury in cancer patients [PDF]

, 2021
Acute kidney injury (AKI) is a common complication of cancer that occurs in up to 50% of neoplastic patients during the natural history of their disease; furthermore, it has a huge impact on key outcomes such as overall prognosis, length of ...
Capasso G., Cosmai L., Foramitti M., Gallieni M., Mollica L., Perrone V., Porta C.   +6 more
core   +4 more sources

Novel and Replicated Clinical and Genetic Risk Factors for Toxicity From High-Dose Methotrexate in Pediatric Acute Lymphoblastic Leukemia [PDF]

, 2023
STUDY OBJECTIVE: Methotrexate (MTX) is a key component of treatment for high-risk pediatric acute lymphoblastic leukemia (ALL) but may cause acute kidney injury and prolonged hospitalization due to delayed clearance.
Bernhardt, M Brooke, Kamdar, Kala Y, Lupo, Philip J, Rabin, Karen R, Scheurer, Michael E, Zobeck, Mark   +5 more
core   +2 more sources

Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus [PDF]

, 2016
Although there are high survival rates for children with acute lymphoblastic leukaemia, their outcome is often counterbalanced by the burden of toxic effects.
Attarbaschi, Andishe, Barzilai, Shlomit, Escherich, Gabriele, Frandsen, Thomas Leth, Halsey, Christina, Hough, Rachael, Jeha, Sima, Kato, Motohiro, Liang, Der-Cherng, Mikkelsen, Torben Stamm, Moricke, Anja, Niinimaki, Riitta, Piette, Caroline, Putti, Maria Caterina, Raetz, Elizabeth, Schmiegelow, Kjeld, Silverman, Lewis B., Skinner, Roderick, Tuckuviene, Ruta, van der Sluis, Inge, Zapotocka, Ester   +20 more
core   +2 more sources

Challenges in implementing individualized medicine illustrated by antimetabolite therapy of childhood acute lymphoblastic leukemia [PDF]

, 2011
Predicting the response to medical therapy and subsequently individualizing the treatment to increase efficacy or reduce toxicity has been a longstanding clinical goal.
Jacob Nersting, Kjeld Schmiegelow, Louise Borst   +2 more
core   +3 more sources

Higher incidence of delayed methotrexate clearance in pediatric acute lymphoblastic leukemia patients treated with imatinib

EJC Paediatric Oncology, 2023
Background: Pediatric patients with Philadelphia chromosome positive (Ph+) or ABL-class fusion positive acute lymphoblastic leukemia (ALL) are currently treated with the tyrosine kinase inhibitor (TKI) imatinib added to a chemotherapy backbone that also ...
Inge M. van der Sluis, Nikita D. van Dijk, Leiah J. Brigitha, Freya M. Steinhauer, Rob Pieters   +4 more
doaj   +1 more source

Mucocutaneous Ulcerations and Pancytopenia Secondary to Methotrexate Toxicity in a Patient With Rheumatoid Arthritis: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Toxicity from methotrexate overdosing is life threatening condition that requires prompt recognition and early treatment. A 71‐year‐old man from rural Bhutan with diabetes mellitus had symmetrical small joint pain for 3 years associated with early morning stiffness.
Dorji T, Penjor T, Tenzin S, Pedon T, Wangchuck S, Yangchen S.   +5 more
europepmc   +2 more sources