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A general introduction to glucocorticoid biology [PDF]

open access: yesFrontiers in Immunology, 2019
Glucocorticoids (GCs) are steroid hormones widely used for the treatment of inflammation, autoimmune diseases, and cancer. To exert their broad physiological and therapeutic effects, GCs bind to the GC receptor (GR) which belongs to the nuclear receptor ...
Libert, Claude   +2 more
core   +2 more sources

Effect of Preoperative Nebulised Dexamethasone and Nebulised Magnesium Sulphate on Postoperative Sore Throat in Prone Position Surgeries- A Randomised Double-Blind Study [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2021
Introduction: Postoperative Sore Throat (POST) is a frequently encountered complication after general anaesthesia with tracheal intubation and positional changes.
G Manuj kumar   +6 more
doaj   +1 more source

EFFECTS OF DRUG BETAMETHASONE ON HEMATOLOGICAL PARAMETERS OF RATTUS NORVEGICUS (BERKENHOUT 1769) IN VIVO CONDITIONS [PDF]

open access: yesJournal of IMAB, 2022
Glucocorticoids prevent or suppress the full inflammatory response to the infectious, immunological or physical agents by inhibiting early inflammatory events such as edema or cell exudation. The main effect of glucocorticoids on the inflammatory process
Edhem Hasković   +5 more
doaj   +1 more source

Osteoporosis Due to Hormone Imbalance: An Overview of the Effects of Estrogen Deficiency and Glucocorticoid Overuse on Bone Turnover

open access: yesInternational Journal of Molecular Sciences, 2022
Osteoporosis is a serious health issue among aging postmenopausal women. The majority of postmenopausal women with osteoporosis have bone loss related to estrogen deficiency. The rapid bone loss results from an increase in bone turnover with an imbalance
Chui H Cheng, Li-Ru Chen, Kuo-Hu Chen
semanticscholar   +1 more source

The Hypothalamic-Pituitary-Adrenal Axis: Development, Programming Actions of Hormones, and Maternal-Fetal Interactions

open access: yesFrontiers in Behavioral Neuroscience, 2021
The hypothalamic-pituitary-adrenal axis is a complex system of neuroendocrine pathways and feedback loops that function to maintain physiological homeostasis.
Julietta A. Sheng   +7 more
doaj   +1 more source

Fresh insights into glucocorticoid-induced diabetes mellitus and new therapeutic directions

open access: yesNature Reviews Endocrinology, 2022
Glucocorticoid hormones were discovered to have use as potent anti-inflammatory and immunosuppressive therapeutics in the 1940s and their continued use and development have successfully revolutionized the management of acute and chronic inflammatory ...
Jiaxue Li, C. Cummins
semanticscholar   +1 more source

Glucocorticoids in rheumatoid arthritis: current status and future studies

open access: yesRMD Open, 2020
Since their first use for treating rheumatoid arthritis (RA) in the late 1940s, glucocorticoids (GCs) have been representing a substantial part of the therapeutic arsenal for RA.
Frank Buttgereit   +2 more
doaj   +1 more source

Mistimed sleep and waking activity in humans disrupts glucocorticoid signalling transcripts and SP1, but not plasma cortisol rhythms

open access: yesFrontiers in Physiology, 2022
Cortisol is a robust circadian signal that synchronises peripheral circadian clocks with the central clock in the suprachiasmatic nucleus via glucocorticoid receptors that regulate peripheral gene expression.
Simon N. Archer   +4 more
doaj   +1 more source

Clinical observations of acute onset of myopic optic neuropathy in a real-world setting [PDF]

open access: yesInternational Journal of Ophthalmology, 2021
AIM: To describe the clinical features of acute myopic onset of optic neuropathy and observe the effects of retrobulbar and systemic glucocorticoid therapy in a real-world setting.
Li Liao   +3 more
doaj   +1 more source

Sex ratios and the city: Secondary offspring sex ratios, parental corticosterone, and parental body condition in an urban-adapted bird

open access: yesFrontiers in Ecology and Evolution, 2022
The Trivers–Willard hypothesis states that mothers should adjust their offspring sex ratio according to their own condition and the environment they face during breeding.
Denyelle A. V. Kilgour   +3 more
doaj   +1 more source

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