Results 1 to 10 of about 414,407 (362)

Glucocorticoids in rheumatoid arthritis: current status and future studies

open access: yesRMD Open, 2020
Since their first use for treating rheumatoid arthritis (RA) in the late 1940s, glucocorticoids (GCs) have been representing a substantial part of the therapeutic arsenal for RA.
Frank Buttgereit   +2 more
doaj   +1 more source

The Cyclosporine-A Treatment does not have Harmful Effect on the Linear Growth of Pediatric Patients with Steroid-dependent and Steroid-resistant Nephrotic Syndrome [PDF]

open access: yesChildhood Kidney Diseases, 2016
Purpose This study was performed to evaluate the effects of cyclosporine-A (CsA) on linear growth in pediatric patients with steroid-dependent (SDNS) or resistant nephrotic syndrome (SRNS).
Sang Soo Lee   +6 more
doaj   +1 more source

Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases

open access: yesFrontiers in Molecular Neuroscience, 2023
Neurotrophins including brain-derived neurotrophic factor, BDNF, have critical roles in neuronal differentiation, cell survival, and synaptic function in the peripheral and central nervous system.
Tadahiro Numakawa   +2 more
doaj   +1 more source

Glucocorticoid Exposure Induces Preeclampsia via DampeningLipoxin A4, an Endogenous Anti-Inflammatory and Proresolving Mediator

open access: yesFrontiers in Pharmacology, 2020
The pathogenesis of preeclampsia (PE) involves several pathophysiological processes that may be affected by glucocorticoid (GC). We confirmed previously that GC exposure could result in PE, while PE is linked to a deficiency of lipoxin A4 (LXA4), an ...
Haojing Liu   +5 more
doaj   +1 more source

Peroxiredoxin 6 Knockout Mice Demonstrate Anxiety Behavior and Attenuated Contextual Fear Memory after Receiving Acute Immobilization Stress

open access: yesAntioxidants, 2021
Stress can elicit glucocorticoid release to promote coping mechanisms and influence learning and memory performance. Individual memory performance varies in response to stress, and the underlying mechanism is not clear yet.
Sarayut Phasuk   +4 more
doaj   +1 more source

Glucocorticosteroid-induced complications in patients with idiopathic thrombocytopenic purpura

open access: yesОнкогематология, 2023
Glucocorticosteroids (GCS) are the first-line treatment for idiopathic thrombocytopenic purpura (ITP). Despite their high efficacy in patients with newly diagnosed ITP, an adequate level of platelets remains after GCS withdrawal in only less than 20 % of
S. G. Zakharov   +12 more
doaj   +1 more source

Effect of combining glucocorticoids with Compound A on glucocorticoid receptor responsiveness in lymphoid malignancies [PDF]

open access: yes, 2018
Glucocorticoids (GCs) are a cornerstone in the treatment of lymphoid malignancies such as multiple myeloma (MM) and acute lymphoblastic leukemia (ALL).
Beck, Ilse   +5 more
core   +11 more sources

Advantages of “Soft Steroids” in the Treatment of Inflammatory Eye Diseases. Оverview

open access: yesOftalʹmologiâ, 2021
The purpose to assess the benefits of using soft steroids in the treatment of inflammatory eye disorders according to literature data.Methods. The literature review concerning the administration of the gluco-corticosteroids and combination drugs based on
D. Yu. Maychuk, A. A. Tarkhanova
doaj   +1 more source

The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ. [PDF]

open access: yes, 2017
Chronic glucocorticoid exposure is associated with the development of insulin resistance. We showed that glucocorticoid-induced insulin resistance was attenuated upon ablation of Angptl4, a glucocorticoid target gene encoding the secreted protein ...
Benjamin, Daniel I   +8 more
core   +1 more source

Glucocorticoid Receptor and Adipocyte Biology. [PDF]

open access: yes, 2018
Glucocorticoids are steroid hormones that play a key role in metabolic adaptations during stress, such as fasting and starvation, in order to maintain plasma glucose levels.
Harris, Charles A   +2 more
core   +2 more sources

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