Results 11 to 20 of about 195,219 (266)

Bromodomain Protein BRD4 Accelerates Glucocorticoid Dysregulation of Bone Mass and Marrow Adiposis by Modulating H3K9 and Foxp1

open access: yesCells, 2020
Glucocorticoid provokes bone mass loss and fatty marrow, accelerating osteoporosis development. Bromodomain protein BRD4, an acetyl–histone-binding chromatin reader, regulates stem cell and tissue homeostasis.
Feng-Sheng Wang   +9 more
doaj   +1 more source

Cortisol response to traumatic stress to predict PTSD symptom development – a systematic review and meta-analysis of experimental studies

open access: yesEuropean Journal of Psychotraumatology, 2023
Background: Pre-and post-traumatic hypothalamic–pituitary–adrenal (HPA) axis markers have been studied to predict posttraumatic stress disorder (PTSD) risk, but its acute reactivity cannot be measured in real-life settings.
Sinha Engel   +5 more
doaj   +1 more source

Salvianolate Ameliorates Osteopenia and Improves Bone Quality in Prednisone-Treated Rheumatoid Arthritis Rats by Regulating RANKL/RANK/OPG Signaling

open access: yesFrontiers in Pharmacology, 2021
Rheumatoid arthritis (RA) is closely associated with periarticular osteopenia and leads to a high risk of generalized osteoporosis. Although glucocorticoid (GC) treatment ameliorates joint degradation and manages inflammation in RA, GC application may ...
Xiang Gao   +13 more
doaj   +1 more source

RETRACTED: Glucocorticoids Should Be Used With Caution in Patients With SARS-CoV-2

open access: yesFrontiers in Medicine, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic, and the use of glucocorticoids in clinical practice is controversial.
Yong Guo   +3 more
doaj   +1 more source

Association Between NR3C1 Mutations and Glucocorticoid Resistance in Children With Acute Lymphoblastic Leukemia

open access: yesFrontiers in Pharmacology, 2021
Treatment outcomes in children with acute lymphoblastic leukemia (ALL) have been improved substantially, with a cure rate exceeding 80% using conventional therapy.
Haiyan Liu   +9 more
doaj   +1 more source

Type 1 interferon suppresses expression and glucocorticoid induction of glucocorticoid-induced leucine zipper (GILZ)

open access: yesFrontiers in Immunology, 2022
SLE is a systemic multi-organ autoimmune condition associated with reduced life expectancy and quality of life. Glucocorticoids (GC) are heavily relied on for SLE treatment but are associated with detrimental metabolic effects.
Wendy Dankers   +15 more
doaj   +1 more source

A rare case of pancytopenia causing‐ Sheehan's syndrome: Case report and literature review

open access: yesClinical Case Reports, 2023
We describe the case of a 58‐year‐old woman who was presented with pancytopenia and hypofibrinogenemia. Treatment with iron supplementation was not satisfactory.
Xiao‐Han Gao   +6 more
doaj   +1 more source

Clinical Features of Hypersensitivity Pneumonitis in Children: A Single Center Study

open access: yesFrontiers in Pediatrics, 2022
BackgroundHypersensitivity pneumonia (HP) is an interstitial lung disease (ILD) mainly involving small airways and lung parenchyma that is caused by the inhalation of antigens in susceptible people to stimulate the body's immune response.MethodsA total ...
Feizhou Zhang   +6 more
doaj   +1 more source

Glucocorticoid effects in the regenerating fin reflect tissue homeostasis disturbances in zebrafish by affecting Wnt signaling

open access: yesFrontiers in Endocrinology, 2023
As a treatment for various immune-mediated diseases, the use of glucocorticoids as anti-inflammatory and immunosuppressive agents is common practice.
Lisa Fleischhauer   +7 more
doaj   +1 more source

Positive Association Between Fluoroquinolone Exposure and Tendon Disorders: A Nationwide Population-Based Cohort Study in Taiwan

open access: yesFrontiers in Pharmacology, 2022
Introduction: Fluoroquinolone exposure is reportedly associated with a higher risk of tendon disorders, tendonitis, or tendon rupture. However, studies in East Asian populations have not confirmed these risks in patients with comorbidities or concomitant
Chun-Kai Chang   +16 more
doaj   +1 more source

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