Results 11 to 20 of about 460,157 (392)
A General Introduction to Glucocorticoid Biology [PDF]
Frontiers in Immunology, 2019 Glucocorticoids (GCs) are steroid hormones widely used for the treatment of inflammation, autoimmune diseases, and cancer. To exert their broad physiological and therapeutic effects, GCs bind to the GC receptor (GR) which belongs to the nuclear receptor ...
S. Timmermans +2 more
semanticscholar +3 more sources
Frontiers in Ecology and Evolution, 2022 The Trivers–Willard hypothesis states that mothers should adjust their offspring sex ratio according to their own condition and the environment they face during breeding.
Denyelle A. V. Kilgour +3 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2022 BackgroundFulminant myocarditis (FM) is a serious non-specific inflammatory disease of the myocardium. FM tends to occur in adolescents and the course of the disease progresses rapidly.
Huanhuan Li, Lun Li
doaj +1 more source
Triple Inhaled Therapy at Two Glucocorticoid Doses in Moderate-to-Very-Severe COPD.
New England Journal of Medicine, 2020 BACKGROUND Triple fixed-dose regimens of an inhaled glucocorticoid, a long-acting muscarinic antagonist (LAMA), and a long-acting β2-agonist (LABA) for chronic obstructive pulmonary disease (COPD) have been studied at single dose levels of inhaled ...
K. Rabe +13 more
semanticscholar +1 more source
BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects
Nature Communications, 2021 Stress-induced glucocorticoids disturb mitochondrial bioenergetics and dynamics; however, instead of being removed via mitophagy, the damaged mitochondria accumulate.
G. Choi +8 more
semanticscholar +1 more source
Glucocorticoids in Sepsis: To Be or Not to Be
Frontiers in Immunology, 2020 Sepsis is a highly lethal syndrome resulting from dysregulated immune and metabolic responses to infection, thereby compromising host homeostasis. Activation of the hypothalamic-pituitary-adrenal (HPA) axis and subsequently adrenocortical glucocorticoid (GC) production during sepsis are important regulatory processes to maintain homeostasis.
Jolien Vandewalle +3 more
openaire +4 more sources
The emerging roles of GPR158 in the regulation of the endocrine system
Frontiers in Cell and Developmental Biology, 2022 G protein-coupled receptor 158 (GPR158) is a member of class C G protein-coupled receptors (GPCRs) and is highly expressed in the central nervous system (CNS) while lowly expressed in peripheral tissues.
Jinju Lin +3 more
doaj +1 more source
Heterogeneous natural history of Addison’s disease: mineralocorticoid deficiency may predominate
Endocrine Connections, 2022 Autoimmune Addison’s disease (AAD) is defined as primary adrenal insufficiency due to immune-mediated destruction of the adrenal cortex. This destruction of steroid-producing cells has historically been thought of as an irreversible process, with linear ...
Sophie Howarth +3 more
doaj +1 more source
Coronavirus fulminant myocarditis treated with glucocorticoid and human immunoglobulin
European Heart Journal, 2020 BNP 139ng/L.
Hongde Hu +3 more
semanticscholar +1 more source
The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ. [PDF]
, 2017 Chronic glucocorticoid exposure is associated with the development of insulin resistance. We showed that glucocorticoid-induced insulin resistance was attenuated upon ablation of Angptl4, a glucocorticoid target gene encoding the secreted protein ...
Benjamin, Daniel I +8 more
core +1 more source