Results 21 to 30 of about 414,407 (362)

A novel human glucocorticoid receptor SNP results in increased transactivation potential. [PDF]

, 2017
Glucocorticoids are one of the most widely used therapeutics in the treatment of a variety of inflammatory disorders. However, it is known that there are variable patient responses to glucocorticoid treatment; there are responders and non-responders, or ...
Cho, Kiho, Green, Tajia L, Greenhalgh, David G, Leventhal, Stacey M, Lim, Debora, Tung, Kelly   +5 more
core   +3 more sources

Clinicopathologic and gastrointestinal effects of administration of prednisone, prednisone with omeprazole, or prednisone with probiotics to dogs: A double‐blind randomized trial

Journal of Veterinary Internal Medicine, 2023
Background The efffect of administering of probiotics or twice‐daily omeprazole on glucocorticoid‐induced gastric bleeding in dogs is unknown. Hypothesis Compare gastrointestinal bleeding among dogs administered placebo, prednisone (2 mg/kg q24h ...
Mariola B. Rak, Tamberlyn D. Moyers, Joshua M. Price, Jacqueline C. Whittemore   +3 more
doaj   +1 more source

Glucocorticoid induced group 2 innate lymphoid cell overactivation exacerbates experimental colitis

Frontiers in Immunology, 2022
Abnormal activation of the innate and adaptive immune systems has been observed in inflammatory bowel disease (IBD) patients. Anxiety and depression increase the risk of IBD by activating the adaptive immune system.
Bingcheng Feng, Bingcheng Feng, Lin Lin, Lin Lin, Lixiang Li, Lixiang Li, Xin Long, Xin Long, Chao Liu, Chao Liu, Zixiao Zhao, Zixiao Zhao, Shiyang Li, Yanqing Li, Yanqing Li   +14 more
doaj   +1 more source

Glucocorticoids for human skin: New aspects of the mechanism of action [PDF]

, 2005
Topical glucocorticoids have always been considered first-line drugs for inflammatory diseases of the skin and bronchial system. Applied systemically, glucocorticoids are used for severe inflammatory and immunological diseases and the inhibition of ...
Ahmed, M., Holtje, H. D., Kleuser, B., Korting, Hans Christian, Schäfer-Korting, Monika   +4 more
core   +1 more source

Re-analysis of Single Cell Transcriptome Reveals That the NR3C1-CXCL8-Neutrophil Axis Determines the Severity of COVID-19

Frontiers in Immunology, 2020
SARS-CoV-2 infection has recently been declared a pandemic. Some patients showing severe symptoms exhibit drastic inflammation and airway damage. In this study, we re-analyzed published scRNA-seq data of COVID-19 patient bronchoalveolar lavage fluid to ...
Jang Hyun Park, Heung Kyu Lee, Heung Kyu Lee   +2 more
doaj   +1 more source

Diagnosis and treatment of canine hypoadrenocorticism [PDF]

, 2018
Canine hypoadrenocorticism (Addison’s disease), the ‘great pretender’ of internal medicine, is a disease that should be frequently considered as a differential diagnosis of several clinical presentations, albeit it is less commonly the actual cause of ...
Gunn, Eilidh, Ramsey, Ian, Spence, Susanna   +2 more
core   +1 more source

Glucocorticoids

, 2016
The most effective anti-inflammatory drugs used to treat patients with airways disease are topical glucocorticosteroids (GCs). These act on virtually all cells within the airway to suppress airway inflammation or prevent the recruitment of inflammatory cells into the airway.
Adcock, IM, Mumby, S
openaire   +4 more sources

Selective glucocorticoid receptor properties of GSK866 analogs with cysteine reactive warheads [PDF]

, 2017
Synthetic glucocorticoids (GC) are the mainstay therapy for treatment of acute and chronic inflammatory disorders. Due to the high adverse effects associated with long-term use, GC pharmacology has focused since the nineties on more selective GC ligand ...
Atucha, Avenant, Baiula, Barnes, Bauer, Baumer, Beck, Berk, Biggadike, Bledsoe, Bonvini, Carson, Cheatham, Chen, Corne, De Bosscher, De Bosscher, De Bosscher, De Vos, Desmet, Desmet, Engel, Garuti, Helsens, Lieber, Liu, Madauss, Mcmaster, Meijsing, Newton, Newton, Perkins, Proksch, Ratman, Rehman, Reichardt, Rhen, Roskoski, Ryabtsova, Schacke, Schacke, Schacke, Schacke, Schindelin, Schuttelkopf, Shafiee, Simons, Simons, Simons, Singh, Sundahl, Touw, Trott, Vanden Berghe, Vanden Berghe, Vandevyver, Vane, Vanhaesebroeck, Verschuuren, Vettorazzi, Wang, Werkstrom   +61 more
core   +2 more sources

The Antiasthma Medication Ciclesonide Suppresses Breast Cancer Stem Cells through Inhibition of the Glucocorticoid Receptor Signaling-Dependent YAP Pathway

Molecules, 2020
Ciclesonide is an FDA-approved glucocorticoid used to treat asthma and allergic rhinitis. However, whether it has anticancer and anti-cancer stem cell (CSC) effects is unknown.
Su-Lim Kim, Hack Sun Choi, Ji-Hyang Kim, Dong-Sun Lee   +3 more
doaj   +1 more source

The Protective Role of Alpha-Ketoglutaric Acid on the Growth and Bone Development of Experimentally Induced Perinatal Growth-Retarded Piglets

Animals, 2021
The effect of alpha-ketoglutaric acid (AKG) supplementation to experimentally-induced, perinatal growth-retarded piglets was examined. Sows were treated with a synthetic glucocorticoid (Gc) during the last 25 days of pregnancy, and after the birth ...
Ewa Tomaszewska, Natalia Burmańczuk, Piotr Dobrowolski, Małgorzata Świątkiewicz, Janine Donaldson, Artur Burmańczuk, Maria Mielnik-Błaszczak, Damian Kuc, Szymon Milewski, Siemowit Muszyński   +9 more
doaj   +1 more source