Results 31 to 40 of about 460,157 (392)

Evolution of glucocorticoid receptors with different glucocorticoid sensitivity [PDF]

Journal of Endocrinology, 2006
Glucocorticoids (GCs) are commonly used to treat a variety of immune diseases. However, the efficacy of treatment is greatly influenced by an individual variation in sensitivity to GCs, which is caused by differences in the glucocorticoid receptor (GR). The variable receptor profile results from variations in the GR gene, or alternative splicing of the
Gert Flik, Huub F. J. Savelkoul, B.M. Lidy Verburg-van Kemenade, Ellen H. Stolte, Ellen H. Stolte   +4 more
openaire   +5 more sources

Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression [PDF]

, 2009
The glucocorticoid receptor (GR) affects the transcription of genes involved in diverse processes, including energy metabolism and the immune response, through DNA-binding dependent and independent mechanisms.
Belitsky, Bolton, De Bosscher, De Bosscher, Dervan, Gigu  re, Heck, Hermoso, Hsu, K. A. Muzikar, Kielkopf, Lampson, Lee, Li, McKay, N. G. Nickols, P. B. Dervan, Pratt, Reichardt, Ren, Spencer, Stockwell, Trauger, Wang, White, Wu, Young   +26 more
core   +2 more sources

Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis. [PDF]

, 2017
Glucocorticoids promote lipolysis in white adipose tissue (WAT) to adapt to energy demands under stress, whereas superfluous lipolysis causes metabolic disorders, including dyslipidemia and hepatic steatosis. Glucocorticoid-induced lipolysis requires the
Broughton, Augusta E, Chen, Tzu-Chieh, Kuo, Taiyi, Lee, Rebecca A, Nguyen, Nguyen Huynh Thao, Wang, Jen-Chywan, Zhang, Danyun   +6 more
core   +1 more source

Postmalaria Neurologic Syndrome: A Case Report

Kaohsiung Journal of Medical Sciences, 2006
Neurologic signs and symptoms are common in acute malarial infection. However, after the parasites have been cleared from the blood and patients recover full consciousness, neurologic or psychiatric symptoms may occur or recur within 2 months after the ...
Cheng-Fang Hsieh, Pang-Ying Shih, Ruey-Tay Lin   +2 more
doaj   +1 more source

Discovery of Novel GR Ligands toward Druggable GR Antagonist Conformations Identified by MD Simulations and Markov State Model Analysis

Advanced Science, 2022
Binding of different ligands to glucocorticoid receptor (GR) may induce different conformational changes and even trigger completely opposite biological functions.
Xueping Hu, Jinping Pang, Jintu Zhang, Chao Shen, Xin Chai, Ercheng Wang, Haiyi Chen, Xuwen Wang, Mojie Duan, Weitao Fu, Lei Xu, Yu Kang, Dan Li, Hongguang Xia, Tingjun Hou   +14 more
doaj   +1 more source

Physical Therapy versus Glucocorticoid Injection for Osteoarthritis of the Knee.

New England Journal of Medicine, 2020
BACKGROUND Both physical therapy and intraarticular injections of glucocorticoids have been shown to confer clinical benefit with respect to osteoarthritis of the knee.
G. Deyle, Christopher S Allen, S. Allison, Norman W. Gill, Ben R. Hando, Evan J Petersen, Douglas I Dusenberry, Daniel I. Rhon   +7 more
semanticscholar   +1 more source

Selective glucocorticoid receptor-activating adjuvant therapy in cancer treatments [PDF]

, 2016
Although adverse effects and glucocorticoid resistance cripple their chronic use, glucocorticoids form the mainstay therapy for acute and chronic inflammatory disorders, and play an important role in treatment protocols of both lymphoid malignancies and ...
Beck, Ilse, Bracke, Marc, Clarisse, Dorien, Offner, Fritz, Sundahl, Nora, Vanden Berghe, Wim   +5 more
core   +2 more sources

Wnt Inhibitors and Bone Turnover Markers in Patients With Polymyalgia Rheumatica and Acute Effects of Glucocorticoid Treatment

Frontiers in Medicine, 2020
Background: In polymyalgia rheumatica (PMR), data on bone turnover markers (BTM), on Wnt inhibitors (Dkk-1, sclerostin) and their changes induced by glucocorticoids (GC) are lacking.
Angelo Fassio, Giovanni Adami, Luca Idolazzi, Alessandro Giollo, Ombretta Viapiana, Elisabetta Vantaggiato, Camilla Benini, Maurizio Rossini, Christian Dejaco, Christian Dejaco, Davide Gatti   +10 more
doaj   +1 more source

Allergic Bronchopulmonary Mycosis Caused by Mucor Overlapping With Invasive Pulmonary Mucormycosis: A Case Report

Frontiers in Medicine, 2022
Mucormycosis is a rare and invasive fungal infection with high mortality. Cases of invasive pulmonary mucormycosis that involve allergic reactions such as allergic bronchopulmonary mycosis are rarely reported.
Ruhui Zhang, Ge Jin, Yasheng Zhan, Lisha Shen, Yake Yao, Qiqi Gao, Qing Yang, Jianying Zhou, Hua Zhou   +8 more
doaj   +1 more source

Glucocorticoids

, 2016
The most effective anti-inflammatory drugs used to treat patients with airways disease are topical glucocorticosteroids (GCs). These act on virtually all cells within the airway to suppress airway inflammation or prevent the recruitment of inflammatory cells into the airway.
Adcock, IM, Mumby, S
openaire   +4 more sources