Results 31 to 40 of about 443,164 (406)

Stability analysis of a hypothalamic-pituitary-adrenal axis model with inclusion of glucocorticoid receptor and memory [PDF]

AIP Conference Proceedings 1798, 020111, 2017, 2016
This paper analyzes a four-dimensional model of the hypothalamic-pituitary-adrenal (HPA) axis that includes the influence of the glucocorticoid receptor in the pituitary. Due to the spatial separation between the hypothalamus, pituitary and adrenal glands, distributed time delays are introduced in the mathematical model.
arxiv   +1 more source

Evolution of glucocorticoid receptors with different glucocorticoid sensitivity [PDF]

Journal of Endocrinology, 2006
Glucocorticoids (GCs) are commonly used to treat a variety of immune diseases. However, the efficacy of treatment is greatly influenced by an individual variation in sensitivity to GCs, which is caused by differences in the glucocorticoid receptor (GR). The variable receptor profile results from variations in the GR gene, or alternative splicing of the
Gert Flik, Huub F. J. Savelkoul, B.M. Lidy Verburg-van Kemenade, Ellen H. Stolte, Ellen H. Stolte   +4 more
openaire   +5 more sources

Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis. [PDF]

, 2017
Glucocorticoids promote lipolysis in white adipose tissue (WAT) to adapt to energy demands under stress, whereas superfluous lipolysis causes metabolic disorders, including dyslipidemia and hepatic steatosis. Glucocorticoid-induced lipolysis requires the
Broughton, Augusta E, Chen, Tzu-Chieh, Kuo, Taiyi, Lee, Rebecca A, Nguyen, Nguyen Huynh Thao, Wang, Jen-Chywan, Zhang, Danyun   +6 more
core   +1 more source

Circadian and Ultradian Rhythms of Free Glucocorticoid Hormone Are Highly Synchronized between the Blood, the Subcutaneous Tissue, and the Brain [PDF]

, 2012
Total glucocorticoid hormone levels in plasma of various species, including humans, follow a circadian rhythm that is made up from an underlying series of hormone pulses. In blood most of the glucocorticoid is bound to corticosteroid-binding globulin and
Droste, Susanne K, Lightman, Stafford L, Linthorst, Astrid C E, Qian, Xiaoxiao, Reul, Johannes M H M   +4 more
core   +1 more source

Postmalaria Neurologic Syndrome: A Case Report

Kaohsiung Journal of Medical Sciences, 2006
Neurologic signs and symptoms are common in acute malarial infection. However, after the parasites have been cleared from the blood and patients recover full consciousness, neurologic or psychiatric symptoms may occur or recur within 2 months after the ...
Cheng-Fang Hsieh, Pang-Ying Shih, Ruey-Tay Lin   +2 more
doaj   +1 more source

Selective glucocorticoid receptor-activating adjuvant therapy in cancer treatments [PDF]

, 2016
Although adverse effects and glucocorticoid resistance cripple their chronic use, glucocorticoids form the mainstay therapy for acute and chronic inflammatory disorders, and play an important role in treatment protocols of both lymphoid malignancies and ...
Beck, Ilse, Bracke, Marc, Clarisse, Dorien, Offner, Fritz, Sundahl, Nora, Vanden Berghe, Wim   +5 more
core   +2 more sources

Physical Therapy versus Glucocorticoid Injection for Osteoarthritis of the Knee.

New England Journal of Medicine, 2020
BACKGROUND Both physical therapy and intraarticular injections of glucocorticoids have been shown to confer clinical benefit with respect to osteoarthritis of the knee.
G. Deyle, Christopher S Allen, S. Allison, Norman W. Gill, Ben R. Hando, Evan J Petersen, Douglas I Dusenberry, Daniel I. Rhon   +7 more
semanticscholar   +1 more source

Improving osteoporosis treatment rates in inpatients admitted with hip fracture: A healthcare improvement initiative in a tertiary referral hospital

AGING MEDICINE, Volume 5, Issue 4, Page 264-271, December 2022., 2022
Our hospital introduced a standardized protocol for the treatment of osteoporosis in patients admitted for hip fracture. The aim of this article was to describe its implementation as well as assess the protocol's effect on treatment rates and safety. In our analysis, there was significant improvement in treatment rates with no instances of acute kidney
Andrew Gan Lin, Nargis Shaheen, Kirtan Ganda, John Cullen, Louise M. Waite, Markus J. Seibel   +5 more
wiley   +1 more source

Discovery of Novel GR Ligands toward Druggable GR Antagonist Conformations Identified by MD Simulations and Markov State Model Analysis

Advanced Science, 2022
Binding of different ligands to glucocorticoid receptor (GR) may induce different conformational changes and even trigger completely opposite biological functions.
Xueping Hu, Jinping Pang, Jintu Zhang, Chao Shen, Xin Chai, Ercheng Wang, Haiyi Chen, Xuwen Wang, Mojie Duan, Weitao Fu, Lei Xu, Yu Kang, Dan Li, Hongguang Xia, Tingjun Hou   +14 more
doaj   +1 more source

Benefits of glucocorticoids in non-ambulant boys/men with Duchenne muscular dystrophy: A multicentric longitudinal study using the Performance of Upper Limb test [PDF]

, 2015
The aim of this study was to establish the possible effect of glucocorticoid treatment on upper limb function in a cohort of 91 non-ambulant DMD boys and adults of age between 11 and 26 years.
Baranello, Giovanni, Barp, Andrea, Battini, Roberta, Bello, Luca, Berardinelli, Angela, Bertini, Enrico, Bianco, Flaviana, Bonfiglio, Serena, Bruno, Claudio, Carlesi, Adelina, Cavallaro, Filippo, D'Amico, Adele, D'Angelo, Grazia, De Sanctis, Roberto, Fanelli, Lavinia, Frosini, Silvia, Gardani, Alice, Gorni, Ksenija, Iotti, Elena, Lanzillotta, Valentina, Mazzone, Elena Stacy, Mercuri, Eugenio, Messina, Sonia, Mongini, Tiziana, Olivieri, Giorgia, Palermo, Concetta, Pane, Marika, Pegoraro, Elena, Petillo, Roberta, Pini, Antonella, Politano, Luisa, Rolle, Enrica, Scutifero, Marianna, Sframeli, Maria, Sivo, Serena, Sormani, Maria Pia, Viggiano, Emanuela, Vita, Gian Luca   +37 more
core   +3 more sources