Reactivation of latent HIV-1 by the glucocorticoid receptor modulator AZD9567. [PDF]
Fayyaz S+7 more
europepmc +1 more source
Comparison of glucocorticoid-receptor binding kinetics with predictions from a biomolecular model.
Joanne M. Yeakley+2 more
openalex +1 more source
Extra-adrenal regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1:physiological regulator and pharmacological target for energy partitioning [PDF]
Alberts+14 more
core +1 more source
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li+12 more
wiley +1 more source
Expression of glucocorticoid-receptor covaries with individual differences in visual lateralisation in zebrafish. [PDF]
Rovegno E+4 more
europepmc +1 more source
Immune Checkpoint Inhibitors and Cardiovascular Adverse Events
Abstract In the last years, we assisted to a tremendous increase in therapeutic options for the management of cancers, with immunotherapy at the forefront of this innovation. Immune checkpoint inhibitors (ICIs) have been developed to enhance the activity of the immune system against cancer cells (1) and the number of approvals for ICIs has rapidly ...
Maria Luisa De Perna+4 more
wiley +1 more source
The Biflavonoid Agathisflavone Regulates Microglial and Astrocytic Inflammatory Profiles via Glucocorticoid Receptor. [PDF]
Almeida ÁMAN+11 more
europepmc +1 more source
Skeletal muscle and subcutaneous fat quantity as prognostic indicators in cardiac amyloidosis
Aims Disease‐related changes in body composition are associated with worse outcomes in chronic heart failure. In cardiac amyloidosis (CA), the prognostic value of direct body composition measures is understudied. Methods and results We identified 160 consecutive patients with CA (transthyretin [ATTR] or light chain [AL]) diagnosed between 2001 and 2021
Joshua Longinow+4 more
wiley +1 more source
The impact of glucocorticoid receptor transactivation on context-dependent cell migration dynamics. [PDF]
Pósa SP+8 more
europepmc +1 more source