Results 241 to 250 of about 231,925 (363)

Green Fluorescent Protein-Glucocorticoid Receptor Knockin Mice Reveal Dynamic Receptor Modulation During Thymocyte Development [PDF]

, 2002
Judson A. Brewer, Barry P. Sleckman, Wojciech Swat, Louis J. Muglia   +3 more
openalex   +1 more source

Efficacy of Telitacicept in Childhood‐Onset Systemic Lupus Erythematosus: A Prospective Multicenter Cohort Study With Inverse Probability of Treatment Weighting –Adjusted Comparison to a Historical Control Group Treated With Belimumab

Arthritis &Rheumatology, EarlyView.
Objective The therapeutic effects of telitacicept combined with standard of care (SoC) in childhood‐onset systemic lupus erythematosus (cSLE) remain unclear. This study aims to evaluate its efficacy in comparison with belimumab combined with SoC.
Chong Luo, Shu Su, Jingyue Liu, Junyu Lin, Jin Song, Zongwen Chen, Yuanyuan Peng, Lijun Jiang, Meng Jia, Li Wang, Xinhui Jiang, Wei Zhang, Zanhua Rong, Bo Zhao, Yajun Wang, Xuemei Tang   +15 more
wiley   +1 more source

Impact of glucocorticoid receptor polymorphism rs6198 on sepsis survival in a prospective multicenter cohort. [PDF]

Sci Rep
Sombetzki C, Palmowski L, Ziehe D, Nowak H, Rahmel T, Ehrentraut SF, Thon P, Orlowski J, Bergmann L, Adamzik M, Koos B, Rump K, SepsisDataNet.NRW research group.   +12 more
europepmc   +1 more source

Identification of histone deacetylase inhibitor targeting type I interferon and B‐cell abnormalities in systemic lupus erythematosus

Arthritis &Rheumatology, Accepted Article.
Objective Systemic lupus erythematosus (SLE) is characterized by increased type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods We identified an inhibitor of IFN‐I production from a chemical library.
Takehiro Hirayama, Hachiro Konaka, Yasuhiro Kato, Takayuki Shibahara, Chisato Nishizawa, Kohei Tsujimoto, JeongHoon Park, Eri Itotagawa, Tatsunori Jo, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Wataru Aoki, Ken J Ishii, Hyota Takamatsu, Atsushi Kumanogoh   +16 more
wiley   +1 more source

The human glucocorticoid receptor variant rs6190 increases blood cholesterol and promotes atherosclerosis. [PDF]

J Clin Invest
Durumutla HB, Haller A, Noble G, Prabakaran AD, McFarland K, Latimer H, Rajput A, Akinborewa O, Namjou-Khales B, Hui DY, Quattrocelli M.   +10 more
europepmc   +1 more source

Immunological Profiling suggests an Association between Treg dysfunction and Pain in Knee Osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Background Pain is the hallmark symptom of osteoarthritis (OA) and its biological drivers remain poorly understood. While the role of innate immunity in OA has been extensively studied, the involvement of adaptive immunity, in particular regulatory T cells (Tregs), is not well understood. Methods We performed omics profiling of peripheral blood from 46
Marie Binvignat, Johanna Dubois, Maria Marco Salvador, Paul Stys, Fabien Pitoiset, Alexandra Roux, Michèle Sastre, Signe Hassler, Roberta Lorenzon, Claire Ribet, Vanessa Mhanna, Hélène Vantomme, Leslie Adda, Pierre Barennes, Nicolas Coatnoan, Kenz Le Gouge, Caroline Aheng, Alice Courties, Lise Minssen, Atul J. Butte, Adrien Six, Michelle Rosenzwajg, Nicolas Tchitchek, Francis Berenbaum, David Klatzmann, Encarnita Mariotti‐Ferrandiz, Jérémie Sellam   +26 more
wiley   +1 more source

TENT5C functions as a corepressor in the ligand-bound glucocorticoid receptor and estrogen receptor α complexes. [PDF]

FEBS J
Li Y, Perera L, He RS, Baptissart M, Petrovich RM, Morgan M.   +5 more
europepmc   +1 more source

The impact of non‐steroidal anti‐inflammatory drugs on radiographic spinal progression in patients with axial spondyloarthritis: 10‐year results from an inception cohort

Arthritis &Rheumatology, Accepted Article.
Objectives This study aims to investigate the impact of non‐steroidal anti‐inflammatory drug (NSAID) intake on radiographic spinal progression in axial spondyloarthritis (axSpA), considering different NSAID types (COX‐2 inhibitors [COX2i] and non‐selective NSAIDs [ns‐NSAIDs]) and disease subgroups (radiographic (r‐axSpA) and non‐radiographic (nr‐axSpA).
Murat Torgutalp, Valeria Rios Rodriguez, Fabian Proft, Mikhail Protopopov, Judith Rademacher, Hildrun Haibel, Joachim Sieper, Martin Rudwaleit, Denis Poddubnyy   +8 more
wiley   +1 more source

Skeletal muscle glucocorticoid receptor density and insulin resistance. [PDF]

, 2002
Chapman, Karen E, Lithell, Hans O, McKeigue, Paul M, Reynolds, Rebecca M, Seckl, Jonathan R, Walker, Brian R   +5 more
core   +1 more source

Androgen receptor-mediated assisted loading of the glucocorticoid receptor modulates transcriptional responses in prostate cancer cells. [PDF]

Genome Res
Hiltunen J, Helminen L, Aaltonen N, Launonen KM, Laakso H, Malinen M, Niskanen EA, Palvimo JJ, Paakinaho V.   +8 more
europepmc   +1 more source