Results 41 to 50 of about 2,551,103 (363)

Insight into glucocorticoid receptor signalling through interactome model analysis. [PDF]

PLoS Computational Biology, 2017
Glucocorticoid hormones (GCs) are used to treat a variety of diseases because of their potent anti-inflammatory effect and their ability to induce apoptosis in lymphoid malignancies through the glucocorticoid receptor (GR). Despite ongoing research, high
Emyr Bakker, Kun Tian, Luciano Mutti, Constantinos Demonacos, Jean-Marc Schwartz, Marija Krstic-Demonacos   +5 more
doaj   +1 more source

NALP3 inflammasome up-regulation and CASP1 cleavage of the glucocorticoid receptor causes glucocorticoid resistance in leukemia cells

Nature Genetics, 2015
Glucocorticoids are universally used in the treatment of acute lymphoblastic leukemia (ALL), and resistance to glucocorticoids in leukemia cells confers poor prognosis.
S. Paugh, Erik J. Bonten, D. Savic, Laura B. Ramsey, William E Thierfelder, Prajwal Gurung, R. Malireddi, Marcelo Actis, Anand Mayasundari, Jaeki Min, David R. Coss, Lucas T. Laudermilk, J. Panetta, J. McCorkle, Yiping Fan, K R Crews, Gabriele Stocco, M. Wilkinson, Antonio M. Ferreira, Cheng Cheng, Wenjian Yang, Seth E. Karol, Christian A. Fernandez, B. Diouf, Colton A. Smith, J. K. Hicks, Alessandra Zanut, Audrey Giordanengo, Dan Crona, Joy J. Bianchi, Linda Holmfeldt, C. Mullighan, M. D. den Boer, Rob Pieters, S. Jeha, Thomas L. Dunwell, Farida Latif, D. Bhojwani, William L. Carroll, Ching-Hon Pui, Richard M. Myers, R. K. Guy, T. Kanneganti, M. Relling, William E. Evans   +44 more
semanticscholar   +1 more source

Fresh insights into glucocorticoid-induced diabetes mellitus and new therapeutic directions

Nature Reviews Endocrinology, 2022
Glucocorticoid hormones were discovered to have use as potent anti-inflammatory and immunosuppressive therapeutics in the 1940s and their continued use and development have successfully revolutionized the management of acute and chronic inflammatory ...
Jiaxue Li, C. Cummins
semanticscholar   +1 more source

The melanocortin receptors and their accessory proteins. [PDF]

, 2013
The five melanocortin receptors (MCRs) named MC1R-MC5R have diverse physiological roles encompassing pigmentation, steroidogenesis, energy homeostasis and feeding behavior as well as exocrine function.
Chan, LF, Clark, AJ, Gorrigan, RJ, Ramachandrappa, S   +3 more
core   +2 more sources

SIRT1: potential target in glucocorticoid-resistant diseases

Frontiers in Immunology
Glucocorticoid resistance is a challenging problem in clinical practice. Increasing glucocorticoid sensitivity and reducing resistance are important in the management of certain diseases.
Jun Xie, Siyi Che, Jiao Liu, Xiaoru Long
doaj   +1 more source

Acquired Glucocorticoid Resistance Due to Homologous Glucocorticoid Receptor Downregulation: A Modern Look at an Age-Old Problem

Cells, 2021
For over 70 years, the unique anti-inflammatory properties of glucocorticoids (GCs), which mediate their effects via the ligand-activated transcription factor, the glucocorticoid receptor alpha (GRα), have allowed for the use of these steroid hormones in
Lee-Maine L. Spies, Nicolette J. D. Verhoog, Ann Louw   +2 more
doaj   +1 more source

Bidirectional crosstalk between Hypoxia-Inducible Factor and glucocorticoid signalling in zebrafish larvae.

PLoS Genetics, 2020
In the last decades in vitro studies highlighted the potential for crosstalk between Hypoxia-Inducible Factor-(HIF) and glucocorticoid-(GC) signalling pathways. However, how this interplay precisely occurs in vivo is still debated. Here, we use zebrafish
Davide Marchi, Kirankumar Santhakumar, Kirankumar Santhakumar, Eleanor Markham, Nan Li, Karl-Heinz Storbeck, Nils Krone, Vincent T Cunliffe, Fredericus J M van Eeden   +8 more
doaj   +1 more source

Expression in hematological malignancies of a glucocorticoid receptor splice variant that augments glucocorticoid receptor-mediated effects in transfected cells [PDF]

, 2001
Glucocorticoids play an important role in the treatment of a number of hematological malignancies, such as multiple myeloma. The effects of glucocorticoids are mediated through the glucocorticoid receptor alpha, the ...
Brinkmann, A.O. (Albert), Brogan, I.J., Jong, F.H. (Frank) de, Koper, J.W. (Jan), Lamberts, S.W.J. (Steven), Lange, P. (Pieter) de, Segeren, C.M. (Christine), Sonneveld, P. (Pieter), White, A. (Arthur), Wiemer, E.A.C. (Erik)   +9 more
core  

Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis. [PDF]

, 2017
Glucocorticoids promote lipolysis in white adipose tissue (WAT) to adapt to energy demands under stress, whereas superfluous lipolysis causes metabolic disorders, including dyslipidemia and hepatic steatosis. Glucocorticoid-induced lipolysis requires the
Broughton, Augusta E, Chen, Tzu-Chieh, Kuo, Taiyi, Lee, Rebecca A, Nguyen, Nguyen Huynh Thao, Wang, Jen-Chywan, Zhang, Danyun   +6 more
core   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source