Results 41 to 50 of about 2,586,604 (408)
Интегративная физиология, 2021 Glucocorticoids (GC) are crucial regulators of homeostasis and function. Despite its negative side effects, glucocorticoid therapy in neonates is widely used antenatally for accelerating fetal lung maturation in cases of preterm birth.
Дмитрий Александрович Ланшаков +4 more
doaj +1 more source
Role of Glucocorticoids and Glucocorticoid Receptors in Glaucoma Pathogenesis
Cells, 2023 The glucocorticoid receptor (GR), including both alternative spliced isoforms (GRα and GRβ), has been implicated in the development of primary open-angle glaucoma (POAG) and iatrogenic glucocorticoid-induced glaucoma (GIG). POAG is the most common form of glaucoma, which is the leading cause of irreversible vision loss and blindness in the world ...
Pinkal D. Patel +2 more
openaire +3 more sources
Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression [PDF]
, 2009 The glucocorticoid receptor (GR) affects the transcription of genes involved in diverse processes, including energy metabolism and the immune response, through DNA-binding dependent and independent mechanisms.
Belitsky +26 more
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F1000Research, 2013 Inhaled glucocorticoids are the first-line treatment for patients with persistent asthma. However, approximately thirty percent of patients exhibit glucocorticoid insensitivity, which may involve excess metabolic clearance of the glucocorticoids by ...
Jessica K Roberts +5 more
doaj +1 more source
Evolution of glucocorticoid receptors with different glucocorticoid sensitivity [PDF]
Journal of Endocrinology, 2006 Glucocorticoids (GCs) are commonly used to treat a variety of immune diseases. However, the efficacy of treatment is greatly influenced by an individual variation in sensitivity to GCs, which is caused by differences in the glucocorticoid receptor (GR). The variable receptor profile results from variations in the GR gene, or alternative splicing of the
Gert Flik +4 more
openaire +5 more sources
Effect of combining glucocorticoids with Compound A on glucocorticoid receptor responsiveness in lymphoid malignancies [PDF]
, 2018 Glucocorticoids (GCs) are a cornerstone in the treatment of lymphoid malignancies such as multiple myeloma (MM) and acute lymphoblastic leukemia (ALL).
Beck, Ilse +5 more
core +3 more sources
Narrative Review: Glucocorticoids in Alcoholic Hepatitis—Benefits, Side Effects, and Mechanisms
Journal of Xenobiotics, 2022 Alcoholic hepatitis is a major health and economic burden worldwide. Glucocorticoids (GCs) are the only first-line drugs recommended to treat severe alcoholic hepatitis (sAH), with limited short-term efficacy and significant side effects. In this review,
Hong Lu
doaj +1 more source
Glucocorticoid receptor expression in 20 solid tumor types using immunohistochemistry assay. [PDF]
, 2017 BackgroundGlucocorticoid receptor (GR) activity plays a role in many aspects of human physiology and may play a crucial role in chemotherapy resistance in a wide variety of solid tumors.
Block, Thaddeus S +4 more
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F1000Research, 2013 Inhaled glucocorticoids are the first-line treatment for patients with persistent asthma. However, approximately thirty percent of patients exhibit glucocorticoid insensitivity, which may involve excess metabolic clearance of the glucocorticoids by ...
Jessica K Roberts +5 more
doaj +1 more source
A novel human glucocorticoid receptor SNP results in increased transactivation potential. [PDF]
, 2017 Glucocorticoids are one of the most widely used therapeutics in the treatment of a variety of inflammatory disorders. However, it is known that there are variable patient responses to glucocorticoid treatment; there are responders and non-responders, or ...
Cho, Kiho +5 more
core +3 more sources