Results 41 to 50 of about 231,925 (363)

Safety and efficacy of fluticasone propionate in the topical treatment of skin diseases [PDF]

, 2004
Fluticasone propionate - the first carbothioate corticosteroid - has been classified as a potent anti-inflammatory drug for dermatological use. It is available as 0.05% cream and 0.005% ointment formulations for the acute and maintenance treatment of ...
Atsuta J, Boner AL, Bridgman A, Callen J, Delescluse J, Dooms-Goossens AE, Dykes PJ, Falcoz C, Fisher DA, Goossens A, Harding SM, Hogger P, James M, Johnson M, Johnson M, Juhlin L, Katz HI, Korting HC, Lebwohl M, Li JT, Liu XQ, Llewellyn-Jones CG, Lucky AW, McKenzie AW, McLean HM, Nurnberger FG, Phillipps GH, Roberts DT, Spencer CM, Tharp MD, Venning VA, Wilkinson SM, Wolkerstorfer A, Young MMR   +33 more
core   +1 more source

Insight into glucocorticoid receptor signalling through interactome model analysis. [PDF]

PLoS Computational Biology, 2017
Glucocorticoid hormones (GCs) are used to treat a variety of diseases because of their potent anti-inflammatory effect and their ability to induce apoptosis in lymphoid malignancies through the glucocorticoid receptor (GR). Despite ongoing research, high
Emyr Bakker, Kun Tian, Luciano Mutti, Constantinos Demonacos, Jean-Marc Schwartz, Marija Krstic-Demonacos   +5 more
doaj   +1 more source

The glucocorticoid receptor in inflammatory processes : transrepression is not enough [PDF]

, 2015
Glucocorticoids (GCs) are the most commonly used anti-inflammatory agents to treat inflammatory and immune diseases. However, steroid therapies are accompanied by severe side-effects during long-term treatment. The dogma that transrepression of genes, by
Dejager, Lien, Hübner, Sabine, Libert, Claude, Tuckermann, Jan P   +3 more
core   +2 more sources

SIRT1: potential target in glucocorticoid-resistant diseases

Frontiers in Immunology
Glucocorticoid resistance is a challenging problem in clinical practice. Increasing glucocorticoid sensitivity and reducing resistance are important in the management of certain diseases.
Jun Xie, Siyi Che, Jiao Liu, Xiaoru Long
doaj   +1 more source

Effects of intrauterine exposure to synthetic glucocorticoids on fetal, newborn, and infant hypothalamic-pituitary-adrenal axis function in humans : a systematic review [PDF]

, 2009
BACKGROUND: Synthetic glucocorticoids are commonly used in reproductive medicine. Fetal organ systems are highly sensitive to changes in the intrauterine environment, including overexposure to glucocorticoids.
1994 Effect of corticosteroids for fetal maturation on perinatal outcomes, Alkalay, Anderson, Andrews, Arlt, Arnold, Asa, Ashwood, Audus, Baker, Ballabh, Ballard, Ballard, Bamberger, Banks, Banks, Barbazanges, Battin, Baulieu, Benassayag, Benediktsson, Bertram, Bettendorf, Blanford, Blettner, Blumenfeld, Bolt, Bolt, Bradley, Bresson, Brosnan, Brown, Burlet, Buske-Kirschbaum, Buske-Kirschbaum, Buske-Kirschbaum, Buske-Kirschbaum, Buttgereit, Carroll, Cattarelli, Charmandari, Christopher Pryce, Chrousos, Cintra, Clifton, Cole, Condon, Crowley, Crowley, Cummings, Czock, Dalziel, Davis, Davis, Dawes, De Kloet, De Kloet, de Kloet, De Kloet, de Kloet, de Weerth, Dean, Dean, Diederich, Diego, Dobbing, Doyle, Dörr, Dörr, Dwan, Easterbrook, Ebrecht, Felszeghy, Fiad, Ford, French, French, Fries, Gatelais, Gayrard, Gennser, Giannakoulopoulos, Giannakoulopoulos, Gibbs, Gitau, Gitau, Glover, Goland, Grier, Grossmann, Gunther Meinlschmidt, Gutteling, Haley, Hanna, Hauser, Haussmann, Heckmann, Heim, Herman, Hingre, Holsboer, Högger, Ioannidis, Jahnukainen, Jaquier, Jeffray, Jobe, Jüni, Kairalla, Kajantie, Kajantie, Kalabis, Kalabis, Kamphuis, Kanitz, Kapoor, Kapoor, Karemaker, Kari, Karlsson, Karssen, Kauppila, Kavelaars, Keene, Kirschbaum, Klemcke, Kononen, Korte, Krauer, Lee, Lee, Lee, Levine, Levitt, Liggins, Liggins, Lindh, Lindsay, Little, Loebstein, MacArthur, Macnaughton, Manabe, Marinoni, Marion Tegethoff, Mark, Mark, Matthews, McAlister, Meadow, Mears, Meijer, Melby, Mesiano, Miller, Modi, Moss, Muneoka, Murphy, Murphy, Murphy, Murphy, National Institutes of Health Consensus Development Panel, Nelson, Nelson, Ng, Ng, Ng, Ng, Ng, Ng, Ng, Noguchi, Nomura, Noorlander, Nordenström, Nykänen, O'Regan, O'Shea, Oelkers, Ohrlander, Ohrlander, Oken, Olufemi, Osathanondh, Owen, Ozawa, Pacheco, Paddock, Parker Jr, Parker Jr, Patel, Peets, Pepe, Pepe, Petersen, Petersen, Petraglia, Petropoulos, Phillips, Pryce, Pryce, Reichardt, Reis, Rizvi, Roberts, Rocci Jr, Rosati, Samtani, Sandesh Kiran, Sapolsky, Sánchez, Schatz, Schwab, Schwab, Seckl, Seckl, Seckl, Serón-Ferré, Shulman, Sippell, Sloboda, Speirs, Speiser, Stein, Streeten, Stroup, Sucheston, Sun, Sybulski, Szabó, Taylor, Tenhola, Teramo, Terrone, Terrone, Thliveris, Trestman, Tsigos, Uhr, Uno, van der Heide-Jalving, Van Hoof, van Runnard Heimel, van Runnard Heimel, Veldhuis, Veldhuis, Vogl, Walters, Watterberg, Welberg, White, Whittaker, Wilson, Wittekind, Yates, Yeh, Yeh   +257 more
core   +2 more sources

Acquired Glucocorticoid Resistance Due to Homologous Glucocorticoid Receptor Downregulation: A Modern Look at an Age-Old Problem

Cells, 2021
For over 70 years, the unique anti-inflammatory properties of glucocorticoids (GCs), which mediate their effects via the ligand-activated transcription factor, the glucocorticoid receptor alpha (GRα), have allowed for the use of these steroid hormones in
Lee-Maine L. Spies, Nicolette J. D. Verhoog, Ann Louw   +2 more
doaj   +1 more source

The glucocorticoid receptor as a regulator of cortisol responses in cortisol resistant patients and healthy subjects [PDF]

, 2013
Glucocorticoids are essential for life, and are involved in growth, reproduction, intermediary metabolism, immune and inflammatory reactions as well as central nervous system and cardiovascular functions.
Ruiz, Mini
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Bidirectional crosstalk between Hypoxia-Inducible Factor and glucocorticoid signalling in zebrafish larvae.

PLoS Genetics, 2020
In the last decades in vitro studies highlighted the potential for crosstalk between Hypoxia-Inducible Factor-(HIF) and glucocorticoid-(GC) signalling pathways. However, how this interplay precisely occurs in vivo is still debated. Here, we use zebrafish
Davide Marchi, Kirankumar Santhakumar, Kirankumar Santhakumar, Eleanor Markham, Nan Li, Karl-Heinz Storbeck, Nils Krone, Vincent T Cunliffe, Fredericus J M van Eeden   +8 more
doaj   +1 more source

The Antiasthma Medication Ciclesonide Suppresses Breast Cancer Stem Cells through Inhibition of the Glucocorticoid Receptor Signaling-Dependent YAP Pathway

Molecules, 2020
Ciclesonide is an FDA-approved glucocorticoid used to treat asthma and allergic rhinitis. However, whether it has anticancer and anti-cancer stem cell (CSC) effects is unknown.
Su-Lim Kim, Hack Sun Choi, Ji-Hyang Kim, Dong-Sun Lee   +3 more
doaj   +1 more source