Glucocorticoid receptor modulators
Annales d'Endocrinologie, 2018 The glucocorticoid hormone cortisol acts throughout the body to support circadian processes and adaptation to stress. The glucocorticoid receptor is the target of cortisol and of synthetic glucocorticoids, which are used widely in the clinic. Both agonism and antagonism of the glucocorticoid receptor may be beneficial in disease, but given the wide ...
Meijer, O.C., Koorneef, L.L., Kroon, J.
openaire +4 more sources
Glucocorticoid Receptor Signaling in Diabetes [PDF]
International Journal of Molecular Sciences, 2021 Stress and depression increase the risk of Type 2 Diabetes (T2D) development. Evidence demonstrates that the Glucocorticoid (GC) negative feedback is impaired (GC resistance) in T2D patients resulting in Hypothalamic-Pituitary-Adrenal (HPA) axis hyperactivity and hypercortisolism.
Ioanna Kokkinopoulou +2 more
openaire +3 more sources
Glucocorticoids rapidly inhibit oxytocin-stimulated adrenocorticotropin release from rat anterior pituitary cells, without modifying intracellular calcium transients [PDF]
, 1993 Glucocorticoid hormones suppress the secretion of ACTH evoked by secretagogues such as CRF and arginine vasopressin. In this study, we investigated the effects of glucocorticoids on ACTH release induced by oxytocin (OT) and on intracellular free calcium ...
Dayanithi, G., Gratzl, Manfred, Link, H.
core +1 more source
Localization of mineralocorticoid receptors at mammalian synapses. [PDF]
PLoS ONE, 2010 In the brain, membrane associated nongenomic steroid receptors can induce fast-acting responses to ion conductance and second messenger systems of neurons.
Eric M Prager +4 more
doaj +1 more source
Cell-Type Specific Changes in Glial Morphology and Glucocorticoid Expression During Stress and Aging in the Medial Prefrontal Cortex. [PDF]
, 2018 Repeated exposure to stressors is known to produce large-scale remodeling of neurons within the prefrontal cortex (PFC). Recent work suggests stress-related forms of structural plasticity can interact with aging to drive distinct patterns of pyramidal ...
Bruce S. McEwen +8 more
core +2 more sources
Neurobiology of Stress, 2022 ‘You can't roll the clock back and reverse the effects of experiences' Bruce McEwen used to say when explaining how allostasis labels the adaptive process.
Nikolaos P. Daskalakis +2 more
doaj +1 more source
Glucocorticoids—All-Rounders Tackling the Versatile Players of the Immune System [PDF]
, 2019 Glucocorticoids regulate fundamental processes of the human body and control cellular functions such as cell metabolism, growth, differentiation, and apoptosis.
Agarwal +268 more
core +1 more source
The glucocorticoid hypothesis of depression: history and perspectives
Вавиловский журнал генетики и селекции, 2016 An abnormality in adaptation to negative life events is considered as one of the main causes of the development of depressive symptoms.
G. T. Shishkina, N. N. Dygalo
doaj +1 more source
Extra-adrenal regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1:physiological regulator and pharmacological target for energy partitioning [PDF]
, 2007 The major glucocorticoid in man, cortisol, plays important roles in regulating fuel metabolism, energy partitioning and body fat distribution.
Alberts +14 more
core +1 more source
Glucocorticoid Receptor–Tethered Mineralocorticoid Receptors Increase Glucocorticoid-Induced Transcriptional Responses [PDF]
Endocrinology, 2019 Mineralocorticoid and glucocorticoid receptors (MRs and GRs) constitute a functionally important dual receptor system detecting and transmitting circulating corticosteroid signals. High expression of MRs and GRs occurs in the same cells in the limbic system, the primary site of glucocorticoid action on cognition, behavior, and mood; however, modes of ...
Caroline A Rivers +5 more
openaire +4 more sources