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Cancer, 2018 It remains unclear whether high doses of glucocorticoids have a negative impact on the efficacy of checkpoint inhibitors. To control for the potential association between immune‐related adverse events (irAEs) and improved survival, this study examined a ...
Alexander Faje +2 more
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Glucocorticoids, Sex Hormones, and Immunity
Frontiers in Immunology, 2018 Glucocorticoid hormones regulate essential body functions in mammals, control cell metabolism, growth, differentiation, and apoptosis. Importantly, they are potent suppressors of inflammation, and multiple immune-modulatory mechanisms involving leukocyte
Oxana Bereshchenko +2 more
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Bad to the Bone: The Effects of Therapeutic Glucocorticoids on Osteoblasts and Osteocytes
Frontiers in Endocrinology, 2022 Despite the continued development of specialized immunosuppressive therapies in the form of monoclonal antibodies, glucocorticoids remain a mainstay in the treatment of rheumatological and auto-inflammatory disorders.
Lorenz C Hofbauer +2 more
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Use of glucocorticoids in the management of immunotherapy‐related adverse effects
Thoracic Cancer, 2020 Immune checkpoint inhibitors (ICIs) activate host antitumor immunity to kill tumor cells. However, ICI therapy may be accompanied by a series of immunotherapy‐related adverse effects (irAEs) caused by activated autoreactive T cells.
Lian Duan, Hanping Wang, Jiaxin Zhou
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Frontiers in Pharmacology, 2021 Aims: To explore the interactive influence of glucocorticoids and cytochrome P450 (CYP450) polymorphisms on voriconazole (VRC) plasma trough concentrations (Cmin) and provide a reliable basis for reasonable application of VRC.Methods: A total of 918 VRC ...
Su-jie Jia, Ren Guo, Xiao-cong Zuo
exaly +3 more sources
Glucocorticoids and Cancer [PDF]
Advances in Experimental Medicine and Biology, 2015 Unlike other steroid hormone receptors, the glucocorticoid receptor (GR) is not considered an oncogene. In breast cancer, the estrogen receptor (ER) drives cell growth, proliferation, and metastasis, and the androgen receptor (AR) plays a similar role in prostate cancer.
M. Pufall
openaire +4 more sources
The Pro-inflammatory Effects of Glucocorticoids in the Brain
Frontiers in Endocrinology, 2016 Glucocorticoids are a class of steroid hormones derived from cholesterol. Their actions are mediated by the glucocorticoid and mineralocorticoid receptors, members of the superfamily of nuclear receptors, which, once bound to their ligands, act as ...
Carolina Demarchi Munhoz
exaly +2 more sources
Immune regulation by glucocorticoids
Nature Reviews Immunology, 2017 A V Anisenkov +2 more
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Molecules, 2023 Glucocorticoids are classified in section S9 of the Prohibited List of the World Anti-Doping Agency, due to a potential risk to improving physical performance and causing harm to the health of athletes.
Yuqi Ge +3 more
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Frontiers in Medicine, 2022 Glucocorticoids are commonly used to treat anti-GBM crescentic glomerulonephritis, however, the mechanism underlying its therapeutic effectiveness is not completely understood.
Xiaomei Wu +8 more
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