Frontiers in Pharmacology, 2021 Aims: To explore the interactive influence of glucocorticoids and cytochrome P450 (CYP450) polymorphisms on voriconazole (VRC) plasma trough concentrations (Cmin) and provide a reliable basis for reasonable application of VRC.Methods: A total of 918 VRC ...
Su-jie Jia, Ren Guo, Xiao-cong Zuo
exaly +3 more sources
Use of glucocorticoids in the management of immunotherapy‐related adverse effects
Thoracic Cancer, 2020 Immune checkpoint inhibitors (ICIs) activate host antitumor immunity to kill tumor cells. However, ICI therapy may be accompanied by a series of immunotherapy‐related adverse effects (irAEs) caused by activated autoreactive T cells.
Lian Duan, Hanping Wang, Jiaxin Zhou
exaly +2 more sources
Bad to the Bone: The Effects of Therapeutic Glucocorticoids on Osteoblasts and Osteocytes
Frontiers in Endocrinology, 2022 Despite the continued development of specialized immunosuppressive therapies in the form of monoclonal antibodies, glucocorticoids remain a mainstay in the treatment of rheumatological and auto-inflammatory disorders.
Lorenz C Hofbauer +2 more
exaly +3 more sources
Association between perioperative glucocorticoids and cancer metastasis and survival in patients undergoing radical cystectomy for urothelial carcinoma of the bladder: A single-center retrospective study [PDF]
Investigative and Clinical Urology, 2020 Purpose: Perioperative glucocorticoids have the potential to increase the risk of tumor metastasis. However, the relationship between perioperative glucocorticoids and oncologic outcomes remains controversial. The present study was undertaken to evaluate
Shiyu Mao +8 more
doaj +1 more source
Molecules, 2023 Glucocorticoids are classified in section S9 of the Prohibited List of the World Anti-Doping Agency, due to a potential risk to improving physical performance and causing harm to the health of athletes.
Yuqi Ge +3 more
doaj +1 more source
Frontiers in Medicine, 2022 Glucocorticoids are commonly used to treat anti-GBM crescentic glomerulonephritis, however, the mechanism underlying its therapeutic effectiveness is not completely understood.
Xiaomei Wu +8 more
doaj +1 more source
The different roles of glucocorticoids in the hippocampus and hypothalamus in chronic stress-induced HPA axis hyperactivity. [PDF]
PLoS ONE, 2014 Hypothalamus-pituitary-adrenal (HPA) hyperactivity is observed in many patients suffering from depression and the mechanism underling the dysfunction of HPA axis is not well understood.
Li-Juan Zhu +11 more
doaj +1 more source
Metabolites, 2023 The main glucocorticoids involved in the stress response are cortisol and cortisone in most mammals and corticosterone in birds and rodents. Therefore, these analytes are currently the biomarkers more frequently used to evaluate the physiological ...
María Botía +6 more
doaj +1 more source
Confounding by indication probably distorts the relationship between steroid use and cardiovascular disease in rheumatoid arthritis: results from a prospective cohort study. [PDF]
PLoS ONE, 2014 OBJECTIVE: To evaluate the risk of cardiovascular disease in patients with rheumatoid arthritis exposed to glucocorticoids. METHODS: Retrospective analysis of exposure to glucocorticoids in a prospective cohort of 353 patients with rheumatoid arthritis ...
Alper M van Sijl +3 more
doaj +1 more source
Clinical evidence of an interferon–glucocorticoid therapeutic synergy in COVID-19
Signal Transduction and Targeted Therapy, 2021 Synthetic glucocorticoid dexamethasone is the first trial-proven drug that reduces COVID-19 mortality by suppressing immune system. In contrast, interferons are a crucial component of host antiviral immunity and can be directly suppressed by ...
Yingying Lu +11 more
doaj +1 more source