Results 91 to 100 of about 47,014 (182)

Gout and NLRP3 inflammasome biology

open access: yesArthritis &Rheumatology, Accepted Article.
This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilisation, and self‐resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal‐induced inflammation is reviewed in detail.
Raewyn Poulsen, Nicola Dalbeth
wiley   +1 more source

Partial purification of a glucocorticoid receptor. [PDF]

open access: bronze, 1975
Douglas Failla   +2 more
openalex   +1 more source

Acute cardiovascular effects associated with the use of prescription medications: A Danish nationwide screening study

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aim This study aims to conduct a hypothesis‐generating screening for acute cardiovascular effects of prescription medications. Methods This Danish nationwide screening study was conducted among incident cases of cardiovascular diseases, including myocardial infarction (MI), ischemic stroke (IS), heart failure (HF), venous thromboembolism (VTE),
Saad Hanif Abbasi   +4 more
wiley   +1 more source

Mode of Action of Glucocorticoids

open access: hybrid, 1964
Paul D. Ray   +2 more
openalex   +1 more source

Variability in intestinal drug metabolizing enzymes and transporters in Crohn's disease and potential impact on oral drug absorption

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Sarah Alrubia   +4 more
wiley   +1 more source

The Effect of Zoledronic Acid on Bone Microarchitecture and Strength after Denosumab and Teriparatide Administration: DATA‐HD Study Extension

open access: yesJournal of Bone and Mineral Research, Volume 38, Issue 1, Page 26-34, January 2023., 2023
ABSTRACT The combination of denosumab and teriparatide is an effective treatment strategy in postmenopausal osteoporosis, though skeletal gains are promptly lost when these agents are discontinued. In the DATA‐HD study, we reported that a single dose of zoledronic acid (ZOL) maintains the increases in areal spine and hip bone mineral density (BMD ...
Sabashini K. Ramchand   +6 more
wiley   +1 more source

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