Results 101 to 110 of about 185,707 (269)
A novel method to establish glucocorticoid resistant acute lymphoblastic leukemia cell lines [PDF]
, 2019 Ling Gu, Ge Zhang, Yanle Zhang
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Advanced Healthcare Materials, EarlyView.This study presents a bone‐on‐a‐chip platform incorporating TPMS scaffolds to study geometry‐dependent osteogenesis under dynamic flow. By tuning pore shape and solidity, it precisely controls mechanical cues, revealing how topological features and shear stress affect osteogenic differentiation and matrix formation.
Donggyu Kim +5 more
wiley +1 more source
Harnessing Advances in Bone Tissue Engineering for Design of Bone‐on‐Chip Systems
Advanced Healthcare Materials, EarlyView.Bone‐on‐chip (BoC) systems demonstrate significant potential as next‐generation models to study human (patho)physiology and evaluate new therapies. However, progress toward functional, human‐like BoCs has been hindered by the structural and functional complexity of bone. This perspective discusses how insights from bone tissue engineering can guide BoC
Farhad Sanaei +6 more
wiley +1 more source
Glucocorticoid attenuates acute lung injury through induction of type 2 macrophage
, 2017 Guo-Wei Tu +7 more
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Glucocorticoids exert differential effects on the endothelium in an in vitro model of the blood–retinal barrier [PDF]
, 2018 Anne‐Eva van der Wijk +6 more
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A Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography [PDF]
, 2020 Yangjie Huang +16 more
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Endocrine risk factors for COVID-19: Endogenous and exogenous glucocorticoid excess [PDF]
, 2021 Frederick Vogel, Martín Reincke
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Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs
Advanced Healthcare Materials, EarlyView.Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner +8 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad +3 more
wiley +1 more source
Advanced Science, EarlyView.Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian +26 more
wiley +1 more source