Results 21 to 30 of about 185,707 (269)

Glucocorticoid-induced osteoporosis – a disorder of mesenchymal stromal cells?

Frontiers in Endocrinology, 2011
Glucocorticoids are a class of steroid hormones that are essential to life but cause serious harm in excess. The main clinical features of glucocorticoid excess are due to adverse effects on cells and tissues that arise from a common developmental ...
Mark Stuart Cooper, Rowan eHardy
doaj   +1 more source

Tissue-Specific Actions of Glucocorticoids on Apoptosis: A Double-Edged Sword

Cells, 2013
First described for their metabolic and immunosuppressive effects, glucocorticoids are widely prescribed in clinical settings of inflammation. However, glucocorticoids are also potent inducers of apoptosis in many cell types and tissues. This review will
Amanda L. Gruver-Yates, John A. Cidlowski   +1 more
doaj   +1 more source

Fibrotic pathways and fibroblast-like synoviocyte phenotypes in osteoarthritis

Frontiers in Immunology
Osteoarthritis (OA) is the most common form of arthritis, characterized by osteophyte formation, cartilage degradation, and structural and cellular alterations of the synovial membrane.
Alexandra Damerau, Alexandra Damerau, Emely Rosenow, Dana Alkhoury, Frank Buttgereit, Frank Buttgereit, Timo Gaber, Timo Gaber   +7 more
doaj   +1 more source

Trends and Patterns of Systemic Glucocorticoid Prescription in Primary Care Institutions in Southwest China, from 2018 to 2021

Risk Management and Healthcare Policy, 2023
Xiaoyi Li,1,* Zhen Zeng,2,* Xingying Fan,1,3 Wenju Wang,4 Xiaobo Luo,4 Junli Yang,1 Yue Chang1,3,* 1School of Medicine and Health Management, Guizhou Medical University, Guiyang, Guizhou Province, People’s Republic of China; 2Second ...
Li X, Zeng Z, Fan X, Wang W, Luo X, Yang J, Chang Y   +6 more
doaj  

Inhibition of glucocorticoid-induced REDD1 expression by rapamycin in breast cancer cells

Успехи молекулярной онкологии, 2022
Introduction. Glucocorticoids are often used in combination therapy for breast cancer as an adjuvant to increase therapeutic effects of the main cytotoxic drug and to reduce side effects of chemotherapy.
D. D. Grigorieva, E. M. Zhidkova, E. S. Lylova, D. V. Demina, K. I. Kirsanov, G. A. Belitsky, M. G. Yakubovskaya, E. A. Lesovaya   +7 more
doaj   +1 more source

Glucocorticoids Suppress Antimicrobial Autophagy and Nitric Oxide Production and Facilitate Mycobacterial Survival in Macrophages

Scientific Reports, 2017
Chronic administration of glucocorticoids has been shown to render individuals highly susceptible to mycobacterial infection and lead to reactivation of latent bacilli.
Jinli Wang, Ruining Wang, Hui Wang, Xiaofan Yang, Jiahui Yang, Wenjing Xiong, Qian Wen, Li Ma   +7 more
doaj   +1 more source

Bad to the Bone: The Effects of Therapeutic Glucocorticoids on Osteoblasts and Osteocytes

Frontiers in Endocrinology, 2022
Despite the continued development of specialized immunosuppressive therapies in the form of monoclonal antibodies, glucocorticoids remain a mainstay in the treatment of rheumatological and auto-inflammatory disorders.
Manuel Gado, Ulrike Baschant, Ulrike Baschant, Lorenz C. Hofbauer, Lorenz C. Hofbauer, Lorenz C. Hofbauer, Holger Henneicke, Holger Henneicke, Holger Henneicke   +8 more
doaj   +1 more source

Life Course Impact of Glucocorticoids During Pregnancy on Muscle Development and Function

Frontiers in Animal Science, 2021
Maternal stress, such as maternal obesity, can induce severe gestational disease and hormonal disorder which may disrupt fetal organ maturation and further cause endangered early or future health in offspring.
Yang Liu, Qiyue Ding, Wei Guo
doaj   +1 more source

Impacts of different methylprednisolone administration routes in patients with sudden hearing loss or Meniere’s disease

Journal of Otology, 2020
Background: Evidence suggests that glucocorticoids are important in the treatment of sudden hearing loss (SHL) and Meniere’s disease (MD). However, different glucocorticoid administration methods may have a significant impact on treatment outcomes ...
Dan Chen, Zhipeng Li, Qilin Zhou, Yubin Chen, Luoying Yang, Jingqian Tan, Xiangli Zeng, Peng Li   +7 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source