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Glucoraphanin conversion into sulforaphane and related compounds by gut microbiota [PDF]

Frontiers in Physiology
Glucosinolate glucoraphanin, common in cruciferous vegetables, is a biologically stable precursor of isothiocyanates, such as sulforaphane and erucin, potent activators of Nrf2 signaling coordinating an adaptive response to oxidative stress. Sulforaphane
Tetiana R. Dmytriv, Tetiana R. Dmytriv, Oleh Lushchak, Oleh Lushchak, Volodymyr I. Lushchak, Volodymyr I. Lushchak   +5 more
doaj   +7 more sources

Glucoraphanin Accumulation via Glucoraphanin Synthesis Promotion during Broccoli Germination [PDF]

Foods, 2023
Glucoraphanin is an important glucosinolate which is widely distributed in Brassica vegetables and poses an anticancer effect to humans. Although researchers have paid a lot of attention to the changes in glucoraphanin concentration in seedlings of ...
Guangmin Liu, Hongju He, Pengjie Wang, Xirui Zhao, Fazheng Ren   +4 more
doaj   +5 more sources

High-level production of health-beneficial glucoraphanin by multiplex editing of AOP2 gene family in mustard. [PDF]

Plant Biotechnol J
Intake of glucosinolates through the consumption of cruciferous vegetables has been associated with numerous health benefits. In recent decades, glucosinolate glucoraphanin has gained a lot of attention, as its hydrolysis product (sulforaphane) is known ...
Kumar P, Bisht NC.
europepmc   +4 more sources

Correction: Liu et al. Glucoraphanin Accumulation via Glucoraphanin Synthesis Promotion during Broccoli Germination. Foods 2024, 13, 41. [PDF]

Foods
In the original publication [...].
Liu G, He H, Wang P, Zhao X, Ren F.
europepmc   +6 more sources

In Vitro Insights into the Dietary Role of Glucoraphanin and Its Metabolite Sulforaphane in Celiac Disease. [PDF]

Nutrients
Sulforaphane is considered the bioactive metabolite of glucoraphanin after dietary consumption of broccoli sprouts. Although both molecules pass through the gut lumen to the large intestine in stable form, their biological impact on the first intestinal ...
Sonzogni E, Martinelli G, Fumagalli M, Maranta N, Pozzoli C, Bani C, Marrari LA, Di Lorenzo C, Sangiovanni E, Dell'Agli M, Piazza S.   +10 more
europepmc   +4 more sources

Effects of broccoli sprout supplements enriched in glucoraphanin on liver functions in healthy middle-aged adults with high-normal serum hepatic biomarkers: A randomized controlled trial [PDF]

Frontiers in Nutrition, 2022
Sulforaphane (SFN), an isothiocyanate derived from glucoraphanin, has antioxidant, and anti-inflammatory effects that may be beneficial for improving liver function.
Shohei Satomi, Shingo Takahashi, Kazutaka Yoshida, Sunao Shimizu, Takuro Inoue, Tsuyoshi Takara, Hiroyuki Suganuma   +6 more
doaj   +3 more sources

Transcriptional changes in prostate of men on active surveillance after a 12-mo glucoraphanin-rich broccoli intervention—results from the Effect of Sulforaphane on prostate CAncer PrEvention (ESCAPE) randomized controlled trial [PDF]

American Journal of Clinical Nutrition, 2019
Background Epidemiological evidence suggests that consumption of cruciferous vegetables is associated with reduced risk of prostate cancer progression, largely attributed to the biological activity of glucosinolate degradation products, such as ...
Al Kadhi, Omar, Ball, Richard Y, Bernuzzi, Federico, Coode-Bate, Jack, Cooper, Colin S, Dainty, Jack R, Defernez, Marianne, Hughes, Jackie, Kibblewhite, Helen, Melchini, Antonietta, Mills, Robert D, Mithen, Richard F, Mythen, Laura, Needs, Paul W, O'Neill, Carmel M, Saha, Shikha, Savva, George M, Traka, Maria H, Troncoso-Rey, Perla   +18 more
core   +4 more sources

Oral Glucoraphanin and Curcumin Supplements Modulate Key Cytoprotective Enzymes in the Skin of Healthy Human Subjects: A Randomized Trial. [PDF]

Metabolites
Background/Objectives: Oxidative stress plays a pivotal role in skin aging and carcinogenesis. Phytochemicals such as sulforaphane (SF, from broccoli sprouts or seeds) or curcumin (CUR, from turmeric) can be highly protective against this stress.
Chien AL, Liu H, Rachidi S, Feig JL, Wang R, Wade KL, Stephenson KK, Kecici AS, Fahey JW, Kang S.   +9 more
europepmc   +4 more sources

Efficacy of 42-month oral administration of glucoraphanin in preventing cognitive decline in individuals at elevated risk of dementia, including those with mild cognitive impairment: a randomized, double-blind, placebo-controlled pilot study [PDF]

Frontiers in Nutrition
BackgroundNuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates cellular defense mechanisms and has been proposed as a therapeutic target for Alzheimer’s disease (AD).
Sunao Shimizu, Sunao Shimizu, Shuya Kasai, Shuya Kasai, Chieko Suzuki, Tomoya Kon, Hiroyuki Suganuma, Shigenori Suzuki, Koichi Murashita, Shigeyuki Nakaji, Kazushige Ihara, Masahiko Tomiyama, Ken Itoh, Ken Itoh   +13 more
doaj   +3 more sources

Glucoraphanin Triggers Rapid Antidepressant Responses in a Rat Model of Beta Amyloid-Induced Depressive-like Behaviour [PDF]

Pharmaceuticals, 2022
Glucoraphanin (GRA) is a natural compound that has shown beneficial effects in chronic diseases and in central nervous system disorders. Moreover, GRA displayed antidepressant activity in preclinical models.
Paolo Tucci, Maria Bove, Vladyslav Sikora, Stefania Dimonte, Maria Grazia Morgese, Stefania Schiavone, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Luigia Trabace   +8 more
doaj   +3 more sources