Results 81 to 90 of about 19,221 (177)

c-Fos induction by gut hormones and extracellular ATP in osteoblastic-like cell lines [PDF]

, 2016
It is widely accepted that the c-Fos gene has a role in proliferation and differentiation of bone cells. ATP-induced c-Fos activation is relevant to bone homeostasis, because nucleotides that are present in the environment of bone cells can contribute to
A Gartland, A Liedert, A Trümper, AE Grigoriadis, BM Wice, C Kaebisch, C Meier, CJ Dixon, D Xie, DB Henriksen, DB Henriksen, DB Henriksen, DJ Drucker, E Velázquez, EL Pacheco-Pantoja, Elda Leonor Pacheco-Pantoja, IR Orriss, IR Orriss, J Kim, J Parker, James A. Gallagher, Jane P. Dillon, JE Koch, JV Zhang, KA Buckley, M-C Beauvieux, MC Bunck, MJ Hayton, Peter J. M. Wilson, RJ Bollag, S Sasaki-Hamada, S Sasaki-Hamada, S Susini, T Inhoff, T Tsuboi, WB Bowler, William D. Fraser   +36 more
core   +1 more source

Providing holistic care for patients with metabolic dysfunction‐associated steatotic liver disease/metabolic dysfunction‐associated steatohepatitis: Key aspects of clinical assessment and how to develop individualised care plans for surveillance and interventions

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Metabolic dysfunction‐associated steatotic liver disease (MASLD), characterised by hepatic steatosis and metabolic dysfunction (i.e., obesity, type 2 diabetes, dyslipidaemia, and hypertension), is affecting over 30% of the adult population worldwide.
Lanlan Chen, Paul Horn, Frank Tacke
wiley   +1 more source

Glucagon-Like Peptide Receptor-1 Agonists Used for Medically-Supervised Weight Loss in Patients With Hip and Knee Osteoarthritis: Critical Considerations for the Arthroplasty Surgeon

Arthroplasty Today
Patients with morbid obesity and concomitant hip or knee osteoarthritis represent a challenging patient demographic to treat as these patients often present earlier in life, have more severe symptoms, and have worse surgical outcomes following total hip ...
Nathanael D. Heckmann, MD, Ryan Palmer, BS, Cory K. Mayfield, MD, Gligor Gucev, MD, Jay R. Lieberman, MD, Kurt Hong, MD, PhD   +5 more
doaj   +1 more source

Alimentos e nutrientes modulam a libertação de hormonas intestinais anorexígenos.

Acta Médica Portuguesa, 2010
The short-term regulation of food intake controls what, how much and when we eat during one day or a single meal. When ingested, the nutrients produce satiety by means of mechanic stimulation and hormonal release.
Gustavo D Pimentel, Juliane C S Zemdegs
doaj   +1 more source

Molecular regulation of hormone secretion, growth and apoptosis of GLP-1-producing cells [PDF]

, 2013
Type 2 diabetes (T2D) spreads like an epidemic in today’s society, and there is a great need for new and improved treatments. T2D is characterized by hyperglycemia, resulting from impaired insulin production and insulin resistance in peripheral ...
Kappe, Camilla
core   +1 more source

Real‐world effectiveness and safety of tirzepatide in Japanese patients with type 2 diabetes: A multi‐site retrospective study

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Despite the established efficacy of tirzepatide in randomised controlled trials, real‐world effectiveness data in Japanese patients remain limited. This study evaluated the real‐world effectiveness and safety of tirzepatide in Japanese patients with type 2 diabetes over 52 weeks.
Yusuke Minakata, Masaki Miura, Nobuhiro Nakatake, Masahiro Masuzawa   +3 more
wiley   +1 more source

Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation. [PDF]

, 2019
The decrease in incretin effects is an important etiologic component of type 2 diabetes with unknown mechanisms. In an attempt to understand obesity-induced changes in liver oxygen homeostasis, we found that liver HIF-1α expression was increased mainly ...
Bandyopadhyay, Guatam K, Cabrales, Pedro, Lee, Yun Sok, Riopel, Matthew   +3 more
core  

The effect of exogenous GLP-1 on food intake is lost in male truncally vagotomized subjects with pyloroplasty [PDF]

, 2013
Rapid degradation of glucagon-like peptide-1 (GLP-1) by dipeptidyl peptidase-4 suggests that endogenous GLP-1 may act locally before being degraded. Signaling via the vagus nerve was investigated in 20 truncally vagotomized subjects with pyloroplasty and
Deacon, Carolyn F., Hartmann, Bolette, Holst, Jens Juul, Hovendal, Claus, Knop, Filip Krag, Meisner, Søren, Plamboeck, Astrid, Svendsen, Lars Bo, Veedfald, Simon, Vilsbøll, Tina, Wettergren, André   +10 more
core   +1 more source

Physiological roles of the GIP receptor in murine brown adipose tissue

Molecular Metabolism, 2019
Objective: Glucose-dependent insulinotropic polypeptide (GIP) is secreted from the gut in response to nutrient ingestion and promotes meal-dependent insulin secretion and lipid metabolism.
Jacqueline L. Beaudry, Kiran D. Kaur, Elodie M. Varin, Laurie L. Baggio, Xiemin Cao, Erin E. Mulvihill, Holly E. Bates, Jonathan E. Campbell, Daniel J. Drucker   +8 more
doaj   +1 more source

Effects of glucagon-like peptide-I on glucose turnover in rats [PDF]

, 1996
The influences of glucagon-like peptide-I-(7-36) amide (GLP-I; 15 pmol . kg(-1). min(-1)) on glucose turnover were studied in freely moving Wistar rats.
Ahren, B, Holst, JJ, Lindskog, S, Steffens, AB, VanDijk, G   +4 more
core   +2 more sources