Results 51 to 60 of about 19,271 (221)
Incretin-based therapy for type 2 diabetes mellitus is promising for treating neurodegenerative diseases [PDF]
, 2016 Incretin hormones include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Due to their promising action on insulinotropic secretion and improving insulin resistance (IR), incretin-based therapies have become a new ...
Holscher, Christian, Li, Lin, Li, Yanwei
core +1 more source
Anti‐inflammatory role of glucose‐dependent insulinotropic polypeptide in periodontitis [PDF]
Journal of Diabetes Investigation, 2016 AbstractAims/IntroductionThe involvement of glucose‐dependent insulinotropic polypeptide (GIP) on inflammation was explored in atherosclerosis and adipose tissue. Periodontal disease is a chronic inflammatory disease, and is considered one of the diabetic complications.
Suzuki, Yuki +16 more
openaire +2 more sources
Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms
Molecular Metabolism, 2021 Background: Glucose-dependent insulinotropic peptide (GIP) is one of two incretin hormones that communicate nutrient intake with systemic metabolism. Although GIP was the first incretin hormone to be discovered, the understanding of GIP's biology was ...
Jonathan E. Campbell
doaj +1 more source
Effects of Exenatide in a Morbidly Obese Patient with Type 2 Diabetes [PDF]
, 2014 INTRODUCTION: The effect of exenatide in weight loss has been reported. Presented here is a case of a morbidly obese patient with type 2 diabetes using exenatide who dramatically lost her body weight in a year and experienced improved glycemic control ...
Mitsuhiko Noda, Miyako Kishimoto
core +1 more source
Frontiers in Cell and Developmental Biology, 2021 Enteroendocrine cells directly integrate signals of nutrient content within the gut lumen with distant hormonal responses and nutrient disposal via the production and secretion of peptides, including glucose-dependent insulinotropic polypeptide (GIP ...
Nadya M. Morrow +7 more
doaj +1 more source
Treatment of type 2 diabetes by free fatty acid receptor agonists [PDF]
, 2014 Dietary free fatty acids (FFAs), such as ω-3 fatty acids, regulate metabolic and anti-inflammatory processes, with many of these effects attributed to FFAs interacting with a family of G protein-coupled receptors.
Hudson, Brian D. +3 more
core +2 more sources
Adult glucose metabolism in extremely birthweight-discordant monozygotic twins [PDF]
, 2012 AIMS/HYPOTHESIS: Low birthweight (BW) is associated with increased risk of type 2 diabetes. We compared glucose metabolism in adult BW-discordant monozygotic (MZ) twins, thereby controlling for genetic factors and rearing environment.
Beck-Nielsen, H +7 more
core +1 more source
Food Safety and Health, EarlyView.Psidium guajava leaves contain potent bioactive compounds like quercetin, myricetin, and triterpenoids that show antioxidant, antidiabetic, anti‐inflammatory, and anticancer effects. They act by modulating NF‐κB, PPARγ, and α‐glucosidase and by inducing apoptosis and cell cycle arrest.
Muhammad Waqar +10 more
wiley +1 more source
Expression of glucose-dependent insulinotropic polypeptide in the zebrafish
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2009 In mammals, glucose-dependent insulinotropic polypeptide (GIP) is synthesized predominately in the small intestine and functions in conjunction with insulin to promote nutrient deposition. However, little is known regarding GIP expression and function in early vertebrates like the zebrafish, a model organism representing an early stage in the ...
Michelle C, Musson +5 more
openaire +3 more sources
Neuroprotective effects of a GIP analogue in the MPTP Parkinson's disease mouse model [PDF]
, 2016 Parkinson's disease (PD) is a chronic neurodegenerative disease, and there is no cure for it at present. Recent research has indicated a link between type 2 diabetes mellitus (T2DM) and PD, which suggested that a treatment to improve insulin resistance ...
Holscher, Christian +3 more
core +1 more source