Results 71 to 80 of about 872,484 (256)
Molecular Systems Biology, 2012 Dynamic interactions between intracellular networks regulate cellular homeostasis and responses to perturbations. Targeted therapy is aimed at perturbing oncogene addiction pathways in cancer, however, development of acquired resistance to these drugs is
Kakajan Komurov +7 more
doaj +1 more source
Advanced Science, EarlyView.Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li +23 more
wiley +1 more source
, 2018 Li Zhou,1,2 Qinghuan Kong,3 Yunhan Zhang,3 Wei Yang,4 Shan Yan,3 Meihui Li,3 Yidan Wang,3 Yanjie Zhou,3 Huimei Yu,3 Liying Han1 1Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun 130041, China; 2Department of ...
Kong QH +9 more
core
Advanced Science, EarlyView.A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang +13 more
wiley +1 more source
Animal, 2019 The aim of this study was to examine the metabolic response to feed deprivation up to 48 h in low and high yielding lamb genotypes. It was hypothesised that Terminal sired lambs would have decreased plasma glucose and increased plasma non-esterified ...
S.M. Stewart +3 more
doaj +1 more source
Advanced Science, EarlyView.A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang +5 more
wiley +1 more source
Measuring deprivation in Spain [PDF]
This paper analyses the deprivation in Spain based on ECHP data for 1996. Usually, an indirect approach for measuring deprivation or poverty is used with poverty lines. That is, income is used as a proxy for analysing living conditions.
Perez-Mayo, Jesus
core
A Universal Protein Ladder for Standardization of Diverse FRET Assays
Advanced Science, EarlyView.Translating FRET measurements from in vitro to intracellular environments requires universal benchmarks. We present a modular protein ladder using TPR motifs to harmonize data across diverse platforms. This predictable calibration curve bridges single molecule FRET measurements, with cell based measurements including FLIM‐FRET.
Evelyn R. Smith +5 more
wiley +1 more source
Social Welfare, Inequality and Deprivation [PDF]
We provide a characterization of the generalised satisfaction -- in our terminology non-deprivation -- quasi-ordering introduced by S.R. Chakravarty (Keio Economic Studies 34 (1997), 17--32) for making welfare comparisons based on the absence of ...
Brice MAGDALOU (CEREGMIA) +1 more
core
Advanced Science, EarlyView.Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang +9 more
wiley +1 more source