Results 81 to 90 of about 181,947 (306)

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Hypoxia antagonizes glucose deprivation on interleukin 6 expression in an Akt dependent, but HIF-1/2α independent manner.

PLoS ONE, 2013
Although both glucose deprivation and hypoxia have been reported to promote cascades of biological alterations that lead to induction of inflammatory mediators, we hypothesized that glucose deprivation and hypoxia might show neutral, synergistic or ...
Sung Ji Choi, Ik Jae Shin, Kang-Hoon Je, Eun Kyoung Min, Eun Ji Kim, Hee-Sun Kim, Senyon Choe, Dong-Eog Kim, Dong Kun Lee   +8 more
doaj   +1 more source

miRNAs link metabolic reprogramming to oncogenesis [PDF]

, 2013
The most profound biochemical phenotype of cancer cells is their ability to metabolize glucose to lactate, even under aerobic conditions. This alternative metabolic circuitry is sufficient to support the biosynthetic and energy requirements for cancer ...
Hatziapostolou, M, Iliopoulos, D, Polytarchou, C   +2 more
core   +1 more source

Glucose-deprivation increases thyroid cancer cells sensitivity to metformin [PDF]

Endocrine-Related Cancer, 2015
Metformin inhibits thyroid cancer cell growth. We sought to determine if variable glucose concentrations in medium alter the anti-cancer efficacy of metformin. Thyroid cancer cells (FTC133 and BCPAP) were cultured in high-glucose (20 mM) and low-glucose (5 mM) medium before treatment with metformin.
Athanasios, Bikas, Kirk, Jensen, Aneeta, Patel, John, Costello, Dennis, McDaniel, Joanna, Klubo-Gwiezdzinska, Olexander, Larin, Victoria, Hoperia, Kenneth D, Burman, Lisa, Boyle, Leonard, Wartofsky, Vasyl, Vasko   +11 more
openaire   +2 more sources

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Glucose deprivation triggers DCAF1-mediated inactivation of Rheb-mTORC1 and promotes cancer cell survival

Cell Death and Disease
Low glucose is a common microenvironment for rapidly growing solid tumors, which has developed multiple approaches to survive under glucose deprivation. However, the specific regulatory mechanism remains largely elusive.
Miaomiao Li, Wenjing Huang, Yuan Zhang, Yue Du, Shan Zhao, Longhao Wang, Yaxin Sun, Beibei Sha, Jie Yan, Yangcheng Ma, Jinlu Tang, Jianxiang Shi, Pei Li, Lijun Jia, Tao Hu, Ping Chen   +15 more
doaj   +1 more source

DRAM-3 modulates autophagy and promotes cell survival in the absence of glucose [PDF]

, 2015
Macroautophagy is a membrane-trafficking process that delivers cytoplasmic constituents to lysosomes for degradation. The process operates under basal conditions as a mechanism to turnover damaged or misfolded proteins and organelles. As a result, it has
A Kuma, A Stolz, AD Baudot, AM Choi, B Levine, B Levine, B Ravikumar, D Crighton, D Crighton, D Crighton, D Strachan, DJ Klionsky, DW Hailey, EL Axe, EL Eskelinen, F Beaumatin, F Corpet, H Harlin, I Kissova, J O'Prey, J O'Prey, J S Long, J Skommer, JJ Lemasters, JJ Lum, JS Long, K M Ryan, KM Ryan, KM Ryan, L Cong, L Y Lao, LA Bell, LY Mah, M Mrschtik, M O'Prey, MT Rosenfeldt, MT Rosenfeldt, N Mizushima, N Mizushima, P Boya, S Hehlgans, S Wilkinson, SA Tooze, SW Tait, Y Kabeya, Y Kamada, Y Ohsumi, Z Xie   +47 more
core   +2 more sources

3D‐Printed Porous Hydroxyapatite Formed via Enzymatic Mineralization

Advanced Functional Materials, EarlyView.
Bone combines lightness, strength, and the ability to heal, inspiring new materials design. This work introduces a room‐temperature, enzyme‐mediated 3D printing method to create porous hydroxyapatite scaffolds. The process avoids energy‐intensive sintering, preserves bioactivity, and allows control over porosity and mineralization.
Francesca Bono, Anna Puiggalí‐Jou, Greta Cocchi, Mariangela Miccoli, Katharina Maniura‐Weber, Marcy Zenobi‐Wong, Esther Amstad   +6 more
wiley   +1 more source

Protective Effect of 25Mg-Porphyrin-Fullerene Nanoparticles on Oxygen-Glucose Deprivation/Reperfusion Injury in PC12 Cells

Acta Medica Iranica, 2016
We investigated the effects of 25Mg-Porphyrin-Fullerene nanoparticles, (25MgPMC16) smart ferroporphyrin nanoparticles, on PC12 cells exposed to oxygen-glucose deprivation/reperfusion.
Peivand Ghasemzadeh, Seyed Mahdi Rezayat, Sharareh Adeli, Nahid Rahbar-Roshandel   +3 more
doaj  

Non-adherence to eye care in people with diabetes [PDF]

, 2017
Objective Evaluate individual factors that impact adherence to eye care follow-up in patients with diabetes. Design and methods A 4-year retrospective chart review was conducted for 1968 patients with diabetes over age 40 from an urban academic center ...
Dai, Yang, Haller, Julia A., Hark, Lisa A., Leiby, Benjamin E., Mayro, Eileen, Murchison, Ann P., Pizzi, Laura T., Storey, Philip P.   +7 more
core   +2 more sources