Results 201 to 210 of about 61,050 (237)
Oxidative Rearrangements of the Alkaloid Intermediate Geissoschizine
Angewandte Chemie, Volume 137, Issue 24, June 10, 2025.19E‐geissoschizine is a key precursor in the biosynthesis of monoterpene indole alkaloids such as strychnine, ibogaine, and vinblastine. Using enzymatic assays and gene silencing, three CYPs were identified from C. roseus that oxidize this compound to four alkaloid scaffolds: strychnos, sarpagan, akuammiline, and mavacurane. Mutational analysis reveals
Mohamed O. Kamileen +6 more
wiley +2 more sources
Diabetes, Obesity and Metabolism, Volume 27, Issue 7, Page 3957-3966, July 2025.Abstract Objective Data from continuous glucose monitors (CGM) enable the extraction of features descriptive of glycemic dynamics that may provide insight into underlying health status. In this work, we analyse CGM data from a large population of individuals with type 2 diabetes (T2D) and study the association of features with clinical covariates ...
Elizabeth Healey +3 more
wiley +1 more source
Human γδ T Cell Function Is Impaired Upon Mevalonate Pathway Inhibition
Immunology, Volume 175, Issue 3, Page 300-322, July 2025.Mevalonate pathway is important for the effector function of gammadelta T cells. Inhibition of the pathway in vivo and in vitro impairs cytokine and cytotoxic molecule production by mainly affecting protein prenylation and disturbing intracellular signalling in Vdelta2 T cells. Created with Biorender.
Tsz Kin Suen +14 more
wiley +1 more source
Designing for Degradation: Transient Devices Enabled by (Nano)Cellulose
Advanced Materials, Volume 37, Issue 22, June 5, 2025.Recent progress in transient devices enabled by (nano)cellulosic materials is reviewed. Transiency mechanisms, advantages of nanocelluloses, and a suite of applications are discussed. A circular thinking approach coupled with life cycle assessment is applied to critically revisit the potential, advantages, and challenges of nanocellulose‐enabled ...
Lucas J. Andrew +2 more
wiley +1 more source
Agrosystems, Geosciences &Environment, Volume 8, Issue 2, June 2025.Abstract Conventional delayed‐flood rice (Oryza sativa L.; DFR) cultivation in United States faces increasing challenges such as nutrient losses, water scarcity, and greenhouse gas emissions. Alternative furrow‐irrigated rice (FIR) cultivation is gaining interest for its water use efficiency and production flexibility.
Aziz Ahmed +7 more
wiley +1 more source
Alzheimer's &Dementia, Volume 21, Issue 6, June 2025.Abstract INTRODUCTION This study assessed the heterogeneous treatment effects (HTEs) of glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) and sodium‐glucose cotransporter‐2 inhibitors (SGLT2is) on the risk of Alzheimer's disease and related dementias (ADRD). METHODS This target trial emulation study included adults (≥ 50 years) with type 2 diabetes (
Huilin Tang +7 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 27, Issue 7, Page 4011-4016, July 2025.
Frank Snoek +11 more
wiley +1 more source
Applied Organometallic Chemistry, Volume 39, Issue 6, June 2025.Two novel mononuclear Zn(II) (2a) and Mn(II) (2b) complexes and a hetero‐binuclear Zn(II)–Cu(II) (3a) complex have been reported. Their biological properties were examined and their computational studies were performed. Particularly, complexes 2b and 3 were observed to have strong interactions with DNA and showed effective antimicrobial ...
Ali Zengin +6 more
wiley +1 more source
The Effect of Structure Building Small Mammals in a Shifting Arctic Landscape
Ecology and Evolution, Volume 15, Issue 6, June 2025.We examined the effects of structure builders on biogeochemical cycling under future arctic tundra conditions. We found that structures influence nutrient availability and vegetation communities differently between contemporary and future conditions.
Austin Roy, Jennie R. McLaren
wiley +1 more source