Results 11 to 20 of about 9,009 (166)

Glucosylceramide flippases contribute to cellular glucosylceramide homeostasis

Journal of Lipid Research
Lipid transport is an essential cellular process with importance to human health, disease development, and therapeutic strategies. Type IV P-type ATPases (P4-ATPases) have been identified as membrane lipid flippases by utilizing nitrobenzoxadiazole (NBD)-
Natsuki Kita, Asuka Hamamoto, Siddabasave Gowda B. Gowda, Hiroyuki Takatsu, Kazuhisa Nakayama, Makoto Arita, Shu-Ping Hui, Hye-Won Shin   +7 more
doaj   +4 more sources

Improved Inhibitors of Glucosylceramide Synthase [PDF]

Journal of Biological Chemistry, 1999
Previous work has led to the identification of inhibitors of glucosylceramide synthase, the enzyme catalyzing the first glycosylation step in the synthesis of glucosylceramide-based glycosphingolipids. These inhibitors have two identified sites of action: the inhibition of glucosylceramide synthase, resulting in the depletion of cellular ...
L, Lee, A, Abe, J A, Shayman
openaire   +2 more sources

Uptake by neuroblastoma cells of glucosylceramide, glucosylceramide glucosidase, its stimulator protein, and phosphatidylserine [PDF]

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1986
Serum-free cultured neuroblastoma cells (clone NlE-115) have been shown to absorb emulsified glucosylceramide, glucosylceramide glucosidase, an activator protein for the enzyme, and phosphatidylserine from a synthetic medium. Uptake of the enzyme was augmented by phosphatidylserine, and vice versa.
Datta, Subhash C., Snider, R. Michael, Radin, Norman S.   +2 more
openaire   +3 more sources

Qualitative and Quantitative Study of Glycosphingolipids in Human Milk and Bovine Milk Using High Performance Liquid Chromatography–Data-Dependent Acquisition–Mass Spectrometry

Molecules, 2020
Cerebrosides (Crb; including glucosylceramide and galactosylceramide) and lactosylceramide (LacCer) are structurally complex lipids found in many eukaryotic cell membranes, where they play important roles in cell growth, apoptosis, cell recognition and ...
Lin Ma, Bertram Y. Fong, Alastair K. H. MacGibbon, Gillian Norris   +3 more
doaj   +1 more source

Studies of the pathogenesis of Gaucher's disease: tissue distribution and biliary excretion of [14C]L-glucosylceramide in rats

Journal of Lipid Research, 1987
The time course of the clearance from the blood and the tissue localization of [14C]L-glucosylceramide, a nonmetabolizable enantiomorph of D-glucosylceramide that accumulates in Gaucher's disease, has been determined.
T Tokoro, A E Gal, L L Gallo, R O Brady
doaj   +1 more source

CgGCS, Encoding a Glucosylceramide Synthase, Is Required for Growth, Conidiation and Pathogenicity in Colletotrichum gloeosporioides

Frontiers in Microbiology, 2019
Fungal glucosylceramide plays important role in cell division, hyphal formation and growth, spore germination and the modulation of virulence and has recently been considered as target for small molecule inhibitors. In this study, we characterized CgGCS,
Yimei Huang, Yimei Huang, Yimei Huang, Yimei Huang, Bin Li, Bin Li, Bin Li, Bin Li, Jian Yin, Qiaosong Yang, Qiaosong Yang, Qiaosong Yang, Ou Sheng, Ou Sheng, Ou Sheng, Guiming Deng, Guiming Deng, Guiming Deng, Chunyu Li, Chunyu Li, Chunyu Li, Chunhua Hu, Chunhua Hu, Chunhua Hu, Tao Dong, Tao Dong, Tao Dong, Tongxin Dou, Tongxin Dou, Tongxin Dou, Huijun Gao, Huijun Gao, Huijun Gao, Fangcheng Bi, Fangcheng Bi, Fangcheng Bi, Ganjun Yi, Ganjun Yi, Ganjun Yi   +38 more
doaj   +1 more source

β-Glucocerebrosidase Deficiency Activates an Aberrant Lysosome-Plasma Membrane Axis Responsible for the Onset of Neurodegeneration

Cells, 2022
β-glucocerebrosidase is a lysosomal hydrolase involved in the catabolism of the sphingolipid glucosylceramide. Biallelic loss of function mutations in this enzyme are responsible for the onset of Gaucher disease, while monoallelic β-glucocerebrosidase ...
Giulia Lunghi, Emma Veronica Carsana, Nicoletta Loberto, Laura Cioccarelli, Simona Prioni, Laura Mauri, Rosaria Bassi, Stefano Duga, Letizia Straniero, Rosanna Asselta, Giulia Soldà, Alessio Di Fonzo, Emanuele Frattini, Manuela Magni, Nara Liessi, Andrea Armirotti, Elena Ferrari, Maura Samarani, Massimo Aureli   +18 more
doaj   +1 more source

Property-based design of a glucosylceramide synthase inhibitor that reduces glucosylceramide in the brain [PDF]

Journal of Lipid Research, 2012
Synthesis inhibition is the basis for the treatment of type 1 Gaucher disease by the glucosylceramide synthase (GCS) inhibitor eliglustat tartrate. However, the extended use of eliglustat and related compounds for the treatment of glycosphingolipid storage diseases with CNS manifestations is limited by the lack of brain penetration of this drug ...
Scott D. Larsen, Michael W. Wilson, Akira Abe, Liming Shu, Christopher H. George, Paul Kirchhoff, H. D. Hollis Showalter, Jianming Xiang, Richard F. Keep, James A. Shayman   +9 more
openaire   +3 more sources

Intestinal absorption of dietary maize glucosylceramide in lymphatic duct cannulated rats

Journal of Lipid Research, 2010
Sphingolipids are ubiquitous in all eukaryotic organisms. Various physiological functions of dietary sphingolipids, such as preventing colon cancer and improving the skin barrier function, have been recently reported. One of the common sphingolipids used
Tatsuya Sugawara, Tsuyoshi Tsuduki, Saeko Yano, Mayumi Hirose, Jingjing Duan, Kazuhiko Aida, Ikuo Ikeda, Takashi Hirata   +7 more
doaj   +1 more source

Direct quantitative determination of ceramide glycosylation in vivo: a new approach to evaluate cellular enzyme activity of glucosylceramide synthase

Journal of Lipid Research, 2010
Glucosylceramide synthase (GCS or GlcT-1), converting ceramide to glucosylceramide, is a key enzyme for the synthesis of glycosphingolipids. Due to its diverse roles in physiology and diseases, GCS may be a disease marker and drug target.
Vineet Gupta, Gauri A. Patwardhan, Qian-Jin Zhang, Myles C. Cabot, S. Michal Jazwinski, Yong-Yu Liu   +5 more
doaj   +1 more source