Quantification of glucosylceramide in plasma of Gaucher disease patients [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2010 Gaucher disease is a sphingolipidosis that leads to an accumulation of glucosylceramide. The objective of this study was to develop a methodology, based on the extraction, purification and quantification of glucosylceramide from blood plasma, for use in ...
Maria Viviane Gomes Muller +7 more
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LifeSkin barrier function, prevent colon cancer, head and neck cancer, and decrease liver cholesterol. However, the mechanism of action has not yet been elucidated.
Huanghuang Dai +8 more
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CgGCS, Encoding a Glucosylceramide Synthase, Is Required for Growth, Conidiation and Pathogenicity in Colletotrichum gloeosporioides [PDF]
Frontiers in Microbiology, 2019 Fungal glucosylceramide plays important role in cell division, hyphal formation and growth, spore germination and the modulation of virulence and has recently been considered as target for small molecule inhibitors. In this study, we characterized CgGCS,
Yimei Huang +38 more
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Selection of Salt-tolerant Yeast Strains Accumulating Glucosylceramide [PDF]
, 2005 application/pdfDebaryomyces hansenii NBRC 0855 accumulated high amounts of glucosylceramide relative to 25 strains of salt-tolerant yeasts in the genera Candida，Debaryomyces. Kodamaea，and Pichia.
Takakuwa, Naoya +4 more
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Therapeutic potential of targeting ceramide/glucosylceramide pathway in cancer [PDF]
, 2013 Sphingolipids including ceramides and its derivatives such as ceramide-1-phosphate, glucosylceramide (GlcCer), and sphingosine-1-phosphate are essential structural components of cell membranes.
Melis Kartal Yandım +5 more
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Glucosylsphingosine Is a Highly Sensitive and Specific Biomarker for Primary Diagnostic and Follow-Up Monitoring in Gaucher Disease in a Non-Jewish, Caucasian Cohort of Gaucher Disease Patients [PDF]
, 2013 Gaucher disease (GD) is the most common lysosomal storage disorder (LSD). Based on a deficient β-glucocerebrosidase it leads to an accumulation of glucosylceramide. Standard diagnostic procedures include measurement of enzyme activity, genetic testing as
Rolfs, A +59 more
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The association of shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effect [PDF]
, 2006 Receptor-mediated internalization to the endoplasmic reticulum (ER) and subsequent retro-translocation to the cytosol are essential sequential processes required for the productive intoxication of susceptible mammalian cells by Shiga-like toxin-1 (SLTx).
Falguières, T +20 more
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Glucosylceramide (GC) metabolism in Gaucher diseases.
, 2021 Ceramide, glucosylceramide shift between the Golgi apparatus and lysosomes. Ceramides, generated in the ER, are transported to the Golgi apparatus, where UDP-glucosylceramide synthase (UGCG synthase) converts Cer to GC on the cytosolic side of the Golgi [
Margarita M. Ivanova (11604141) +8 more
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Lysosomal membrane integrity in fibroblasts derived from patients with Gaucher disease
Cell Structure and Function, 2023 Gaucher disease (GD) is a recessively inherited lysosomal storage disorder characterized by a deficiency of lysosomal glucocerebrosidase (GBA1). This deficiency results in the accumulation of its substrate, glucosylceramide (GlcCer), within lysosomes ...
Asuka Hamamoto +7 more
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Molecules, 2020 Cerebrosides (Crb; including glucosylceramide and galactosylceramide) and lactosylceramide (LacCer) are structurally complex lipids found in many eukaryotic cell membranes, where they play important roles in cell growth, apoptosis, cell recognition and ...
Lin Ma +3 more
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