Maternal Nutrient Restriction Disrupts Gene Expression and Metabolites Associated with Urea Cycle, Steroid Synthesis, Glucose Homeostasis, and Glucuronidation in Fetal Calf Liver [PDF]
Metabolites, 2022 This study aimed to understand the mechanisms underlying the effects of maternal undernutrition (MUN) on liver growth and metabolism in Japanese Black fetal calves (8.5 months in utero) using an approach that integrates metabolomics and transcriptomics ...
Susumu Muroya +8 more
doaj +2 more sources
Systematic characterization of lysine glucuronidation in a bispecific antibody [PDF]
mAbsThis study presents a systematic characterization of lysine glucuronidation that was revealed during the charge variant characterization of a bispecific antibody (bsAb).
Michael R. Reyda +7 more
doaj +2 more sources
Glucuronidation by UGT1A1 is the dominant pathway of the metabolic disposition of belinostat in liver cancer patients. [PDF]
PLoS ONE, 2013 Belinostat is a hydroxamate class HDAC inhibitor that has demonstrated activity in peripheral T-cell lymphoma and is undergoing clinical trials for non-hematologic malignancies.
Ling-Zhi Wang +16 more
doaj +9 more sources
In Vitro Glucuronidation of Ochratoxin A by Rat Liver Microsomes [PDF]
Toxins, 2013 Ochratoxin A (OTA), one of the most toxic mycotoxins, can contaminate a wide range of food and feedstuff. To date, the data on its conjugates via glucuronidation request clarification and consolidation.
Zheng Han +6 more
doaj +2 more sources
In Vitro Metabolism and Analytical Characterization of SLU-PP-332 and SLU-PP-915: Novel Pan-ERR Agonists With Doping Potential. [PDF]
Rapid Commun Mass SpectromABSTRACT Rationale Estrogen‐related receptor (ERR) agonists such as the drug candidates SLU‐PP‐332 and SLU‐PP‐915 are currently being investigated as exercise mimetics, given their ability to trigger human physiological processes similar to those initiated by actual physical activity.
Möller T, Krug O, Thevis M.
europepmc +2 more sources
Regioselective Glucuronidation of Diosmetin and Chrysoeriol by the Interplay of Glucuronidation and Transport in UGT1A9-Overexpressing HeLa Cells. [PDF]
PLoS ONE, 2016 This study aimed to determine the reaction kinetics of the regioselective glucuronidation of diosmetin and chrysoeriol, two important methylated metabolites of luteolin, by human liver microsomes (HLMs) and uridine-5'-diphosphate glucuronosyltransferase (
Xuejun Zeng +10 more
doaj +3 more sources
Impact of Species and Tissue Differences on In Vitro Glucuronidation of Diclofenac [PDF]
MoleculesBackground: The aim of this study is to determine the impact of species and tissue differences on the glucuronidation of diclofenac in vitro. Method: Microsomes from different species (rat, monkey, mouse, dog, and human) and rat and human tissues (liver,
Eric Asare +5 more
doaj +2 more sources
Frontiers in Pharmacology, 2022 Glucuronidation catalyzed by UDP-glucuronosyltransferases (UGTs) is one of the most important phase II mechanisms, facilitating drug clearance via conjugation of glucuronic acid with polar groups of xenobiotics.
Wanying Zeng +9 more
doaj +1 more source
Variation in trans-3'-hydroxycotinine glucuronidation does not alter the nicotine metabolite ratio or nicotine intake. [PDF]
PLoS ONE, 2013 CYP2A6 metabolizes nicotine to its primary metabolite cotinine and also mediates the metabolism of cotinine to trans-3'-hydroxycotinine (3HC). The ratio of 3HC to cotinine (the "nicotine metabolite ratio", NMR) is an in vivo marker for the rate of CYP2A6
Andy Z X Zhu +5 more
doaj +1 more source
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2012 Alcohol is associated with significant morbidity and mortality. Subjects abusing alcohol can be identified through clinical history, examination or self-report questionnaires. A range of biomarkers is available for detecting alcohol misuse, but there is still a need for a marker that can detect alcohol consumption in the time window between one day ...
Walsham, Natalie E., Sherwood, Roy
openaire +3 more sources